Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 9 of 9
Full-Text Articles in Physical Sciences and Mathematics
Different Radiolabelling Methods Alter The Pharmacokinetic And Biodistribution Properties Of Plasminogen Activator Inhibitor Type 2 (Pai-2) Forms, Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, Andrew Katsifis
Different Radiolabelling Methods Alter The Pharmacokinetic And Biodistribution Properties Of Plasminogen Activator Inhibitor Type 2 (Pai-2) Forms, Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, Andrew Katsifis
Faculty of Science - Papers (Archive)
Introduction: Tumour-associated urokinase plasminogen activator (uPA) is a critical marker of invasion and metastasis, and it is recognised as having strong prognostic relevance as well as being a therapeutic target. The specific uPA inhibitor plasminogen activator inhibitor type-2 (PAI-2, SerpinB2) specifically targets cell bound uPA and is internalised. Furthermore, preclinical studies have established the “proof-of-principle” of uPA-targeting by PAI-2-cytotoxin conjugates in human carcinoma models. However, these studies also suggest that PAI-2 is rapidly cleared via the renal system with low total dose reaching the tumour. In this study, a comparative single photon emission computed tomography (SPECT) and biodistribution (BD) analysis …
Dgt-Induced Copper Flux Predicts Bioaccumulation And Toxicity To Bivalves In Sediments With Varying Properties, Stuart L. Simpson, Heloise Yverneau, Anne Cremazy, Chad V. Jarolimek, Helen Price, Dianne F. Jolley
Dgt-Induced Copper Flux Predicts Bioaccumulation And Toxicity To Bivalves In Sediments With Varying Properties, Stuart L. Simpson, Heloise Yverneau, Anne Cremazy, Chad V. Jarolimek, Helen Price, Dianne F. Jolley
Faculty of Science - Papers (Archive)
Many regulatory frameworks for sediment quality assessment include consideration of contaminant bioavailability. However, the “snap-shots” of metal bioavailability provided by analyses of porewaters or acid-volatile sulfidesimultaneously extractable metal (AVS-SEM) relationships do not always contribute sufficient information. The use of inappropriate or inadequate information for assessing metal bioavailability in sediments may result in incorrect assessment decisions. The technique of diffusive gradients in thin films (DGT) enables the in situ measurement of metal concentrations in waters and fluxes from sediment porewaters. We utilized the DGT technique to interpret the bioavailability of copper to the benthic bivalve Tellina deltoidalis in sediments of varying …
Synthesis, Properties And Water Permeability Of Swnt Buckypapers, L J. Sweetman, L Nghiem, I Chironi, G Triani, Marc In Het Panhuis, St F. Ralph
Synthesis, Properties And Water Permeability Of Swnt Buckypapers, L J. Sweetman, L Nghiem, I Chironi, G Triani, Marc In Het Panhuis, St F. Ralph
Faculty of Science - Papers (Archive)
The ability of macrocyclic ligands to facilitate formation of dispersions of single-walled carbon nanotubes (SWNTs) was investigated using a combination of absorption spectrophotometry and optical microscopy. Vacuum filtration of aqueous dispersions containing SWNTs and various macrocyclic ligands (derivatised porphyrin, phthalocyanine, cyclodextrin and calixarene) afforded self-supporting membranes known as buckypapers. Microanalytical data and energy dispersive X-ray spectra were obtained for these buckypapers and provided evidence for retention of the macrocyclic ligands within the structure of the membranes. The electrical conductivities of the membranes varied between 30 ± 20 and 220 ± 60 S cm−1, while contact angle analysis revealed they all …
Properties Of The B+-H2 And B+-D2 Complexes: A Theoretical And Spectroscopic Study, B L. J Poad, V Dryza, A A. Buchachenko, J Kos, E J. Bieske
Properties Of The B+-H2 And B+-D2 Complexes: A Theoretical And Spectroscopic Study, B L. J Poad, V Dryza, A A. Buchachenko, J Kos, E J. Bieske
Faculty of Science - Papers (Archive)
The rotationally resolved infrared spectrum of the B+-D2 ion-neutral complex is recorded in the D-D stretch vibration region (2805–2875 cm−1) by detecting B+ photofragments. Analysis of the spectrum confirms a T-shaped equilibrium geometry for the B+-D2 complex with a vibrationally averaged intermolecular bond length of 2.247 Å, around 0.02 Å shorter than for the previously characterised B+-H2 complex [V. Dryza, B. L. J. Poad, and E. J. Bieske, J. Am. Chem. Soc. 130, 12986 (2008)10.1021/ja8018302]. The D-D stretch band centre occurs at 2839.76 ± 0.10 cm−1, representing a −153.8 cm−1 shift from the Q1(0) transition of the free D2 molecule. …
The Major Toxin From The Australian Common Brown Snake Is A Hexamer With Unusual Gas-Phase Dissociation Properties, Andrew Aquilina
The Major Toxin From The Australian Common Brown Snake Is A Hexamer With Unusual Gas-Phase Dissociation Properties, Andrew Aquilina
Faculty of Science - Papers (Archive)
Asymmetric dissociation of multiply charged proteins assemblies has been frequently reported. This phenomenon, which relies on the dissociation of one or more highly charged monomers, has been shown to provide insights into the structure and organization of large monodisperse and polydisperse assemblies. Here, the process of asymmetric dissociation is investigated using the multi-subunit protein, textilotoxin, which has unusually high structural constraints on its monomers due to multiple disulfide linkages. Initially, it is shown that, contrary to previous reports, textilotoxin is made up of 6, rather than 5 subunits. Furthermore, the hexamer exists as two isoforms, one of which is substantially …
Investigations Of Electrochemical And Spectroelectrochemical Properties (Uv-Vis, Epr) Of Thiophene Trimer Derivatives Substituted With Phenylvinyl Groups., Pawel W. Wagner, Agnieszka Stolarczyk, Mariola Bartoszek, Mieczyslaw Lapkowski, David L. Officer, Keith C. Gordon, M Jadamiec, Wieslaw W. Sulkowski
Investigations Of Electrochemical And Spectroelectrochemical Properties (Uv-Vis, Epr) Of Thiophene Trimer Derivatives Substituted With Phenylvinyl Groups., Pawel W. Wagner, Agnieszka Stolarczyk, Mariola Bartoszek, Mieczyslaw Lapkowski, David L. Officer, Keith C. Gordon, M Jadamiec, Wieslaw W. Sulkowski
Faculty of Science - Papers (Archive)
The results of investigations concerning electrochem. properties of two thiophene trimers derivs. substituted with phenylvinyl groups {3'[(E)-2-phenylethenyl]-2,2':5',2"-thiophene (monomer A) and 4,4"-didecyloxy-3'[(E)-2-phenylethenyl]-2,2':5',2"-thiophene (monomer B)} and the products of their oxidn. were discussed. Electropolymns. of A and B monomers were carried out with use of cyclic voltammetry and electrochem. measurements were coupled in-situ with spectroscopic methods (UV-Vis, EPR). It was found that A monomer oxidized to oligomers sol. in dichloromethane while monomer B showed ability to form stable conductive polymer layers showing low-energy forbidden band (1.6 eV).
Synthesis And Ph-Responsive Properties Of Pseudo-Peptide Containing Hydrophobic Amino Acid Grafts, Rongjun Chen, Mark E. Eccleston, Zhilian Yue, Nighel K. H Slater
Synthesis And Ph-Responsive Properties Of Pseudo-Peptide Containing Hydrophobic Amino Acid Grafts, Rongjun Chen, Mark E. Eccleston, Zhilian Yue, Nighel K. H Slater
Faculty of Science - Papers (Archive)
Pseudo-peptidic polymers have been synthesised by grafting l-valine (PV), l-leucine (PL) and l-phenylalanine (PP) onto the pendant carboxylic acid moieties of a pH-responsive polyamide, poly(l-lysine isophthalamide). The pH-responsive aqueous solution properties of PV-75, PL-75 and PP-75 with a stoichiometric degree of substitution of 75 mol% have been compared with those of the parent poly(l-lysine isophthalamide) using UV-visible and fluorescence spectroscopy. At low concentrations (≤0.1 mg mL-1), the grafted polymers displayed pH-dependent conformation. The pH at the onset of hydrophobic association (pHh) and the pH range over which association occurred varied significantly between the different amino acid grafts. The pHh values …
The Effect Of Preparation Conditions And Biopolymer Dispersants On The Properties Of Swnt Buckypapers, Jenny Boge, Luke J. Sweetman, Marc In Het Panhuis, Stephen F. Ralph
The Effect Of Preparation Conditions And Biopolymer Dispersants On The Properties Of Swnt Buckypapers, Jenny Boge, Luke J. Sweetman, Marc In Het Panhuis, Stephen F. Ralph
Faculty of Science - Papers (Archive)
The effect of varying preparation conditions on the properties of buckypapers made using single-walled carbon nanotubes (SWNTs) was systematically investigated. Changing the sonication time, final dispersion volume or membrane filter used to prepare SWNT-Triton X-100 buckypapers all generally had only a small influence on the density, thickness, contact angle and electrical conductivity of the resulting material. More significant changes were noted when the effects of variations in the above preparation conditions on the mechanical properties and surface morphology of SWNT-Triton X-100 buckypapers were investigated. However, the largest changes in properties were found when various biopolymers (bovine serum albumin, lysozyme, gellan …
Do Green And Golden Bell Frogs Litoria Aurea Occupy Habitats With Fungicidal Properties?, C G. Threlfall, Dianne F. Jolley, N Evershed, R L. Goldingay, W A. Buttemer
Do Green And Golden Bell Frogs Litoria Aurea Occupy Habitats With Fungicidal Properties?, C G. Threlfall, Dianne F. Jolley, N Evershed, R L. Goldingay, W A. Buttemer
Faculty of Science - Papers (Archive)
The Green and Golden Bell frog Utoria aurea is in major decline in Australia, where its distribution is now confined mainly to the east coast of New South Wales (NSW). Infection by the newly emerged amphibian fungal pathogen Batrachochytrium dendrobatidis has been identified as one of the main threats affecting L aureo. Surprisingly, some of the sites in NSW sustaining the largest populations of this species are industrial and urban habitats that are often disturbed and polluted, which could protect L aurea from chytrid infection if pollution had fungicidal capacity The aim of this study was to characterise the trace …