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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Measuring Markers Of Liver Function Using A Micropatterned Paper Device Designed For Blood From A Fingerstick, Sarah J. Vella, Patrick Beattie, Rebecca Cademartiri, Anna Laromaine, Andres W. Martinez, Scott T. Phillips, Katherine A. Mirica, George M. Whitesides
Measuring Markers Of Liver Function Using A Micropatterned Paper Device Designed For Blood From A Fingerstick, Sarah J. Vella, Patrick Beattie, Rebecca Cademartiri, Anna Laromaine, Andres W. Martinez, Scott T. Phillips, Katherine A. Mirica, George M. Whitesides
Rebecca Cademartiri
This paper describes a paper-based microfluidic device that measures two enzymatic markers of liver function (alkaline phosphatase, ALP, and aspartate aminotransferase, AST) and total serum protein. A device consists of four components: (i) a top plastic sheet, (ii) a filter membrane, (iii) a patterned paper chip containing the reagents necessary for analysis, and (iv) a bottom plastic sheet. The device performs both the sample preparation (separating blood plasma from erythrocytes) and the assays; it also enables both qualitative and quantitative analysis of data. The data obtained from the paper-microfluidic devices show standard deviations in calibration runs and “spiked” standards that …
Macroporous Silica Using A “Sticky” Stöber Process, Rebecca Cademartiri, Michael A. Brook, Robert Pelton, John D. Brennan
Macroporous Silica Using A “Sticky” Stöber Process, Rebecca Cademartiri, Michael A. Brook, Robert Pelton, John D. Brennan
Rebecca Cademartiri
The generation of macroporous silica structures using a sol–gel process generally requires the presence of high molecular weight, water-soluble polymers. We demonstrate that significantly lower molecular weight poly(ethylene glycol) (PEG) polymers can drive a particle aggregation process to generate macroporous silica. Compared to unfunctionalized PEGs (HO–PEG–HO, molecular weight > 10 000 g mol−1), PEG polymers with allyl (A–PEG–A) or silyl end groups (CH2)3Si(OEt)3 (Si–PEG–Si), with molecular weights of 2000 g mol−1 or greater, lead to monolithic macroporous structures derived from aggregates of nearly monodisperse particles. Lower molecular weight (less than 1000 g mol−1) allyl or silyl PEG, or hydroxy-terminated PEG–OH, lead …
Non-Destructive Horseradish Peroxidase Immobilization In Porous Silica Nanoparticles, Rebecca Voss, Michael A. Brook, Jordan Thompson, Yang Chen, Robert H. Pelton, John D. Brennan
Non-Destructive Horseradish Peroxidase Immobilization In Porous Silica Nanoparticles, Rebecca Voss, Michael A. Brook, Jordan Thompson, Yang Chen, Robert H. Pelton, John D. Brennan
Rebecca Cademartiri
The preparation of protein doped silica particles is impeded by the difficulty of incorporating proteins within the silica mesostructure under conditions that do not lead to denaturation. Herein, the synthesis of spherical silica particles (diameter 150 nm–550 nm) under protein friendly conditions in a one step process is described. Diglyceroxysilane (DGS) was reacted in ethanol and methanol-free conditions in pure water or in buffer solutions with or without the presence of additional glycerol. Stabilization of the particles, consistent with steric stabilization, was obtained using poly(ethylene glycol) (PEG) of various molecular weights and with various end groups, including allyl and (CH2)3Si(OEt)3 …
Organosilicas With Chiral Bridges And Self-Generating Mesoporosity, Andreas Ide, Rebecca Voss, Gudrun Scholz, Geoffrey A. Ozin, Markus Antonietti, Arne Thomas
Organosilicas With Chiral Bridges And Self-Generating Mesoporosity, Andreas Ide, Rebecca Voss, Gudrun Scholz, Geoffrey A. Ozin, Markus Antonietti, Arne Thomas
Rebecca Cademartiri
Amine-functionalized, chiral mesoporous organosilicas were prepared from a rationally designed precursor, which combines the functions of a network builder, a chiral latent functional group, and a porogen in one molecule. The precursors are formed by a convenient enantioselective hydroboration using (S)-monoisopinocampheylborane on an ethylene-bridged silica precursor. These precursors do self-organize when hydrolysis of their inorganic moiety takes place via an aggregation of their organic moiety into hydrophobic domains. After a condensation−ammonolysis sequence mesoporous organosilicas functionalized with chiral amine groups are obtained, with the complete chiral functionalities located at the pore wall surface and therefore accessible to chemical processes. The pore …
Synthesis And Characterization Of Highly Amine Functionalized Mesoporous Organosilicas By An “All-In-One” Approach, Rebecca Voss, Arne Thomas, Markus Antonietti, Geoffrey A. Ozin
Synthesis And Characterization Of Highly Amine Functionalized Mesoporous Organosilicas By An “All-In-One” Approach, Rebecca Voss, Arne Thomas, Markus Antonietti, Geoffrey A. Ozin
Rebecca Cademartiri
Mesoporous organosilicas (MOs) represent a promising class of organic–inorganic nanocomposites for a broad range of applications like catalysis, sensing, separation, or microelectronics. Their distinct feature is the presence of organic groups incorporated into the channel walls of a mesoporous structure. Here, we present a convenient “all-in-one” approach using silsesquioxane surfactant precursors for the functionalization of the channel walls with primary amine groups. The monomer is made by a hydroboration/aminolysis sequence on the base of a commercial monomer, with the template bound to the functionalization site by hydroboration and released after silica condensation and aminolysis. This combination ensures both the placement …