Physical Sciences and Mathematics Commons^™

Architecture Of Heptagonal Metallo-Macrocycles Via Embedding Metal Nodes Into Its Rigid Backbone, A.M.Shashika D. Wijerathna, He Zhao, Qiangqiang Dong, Qixia Bai, Zhiyuan Jiang, Jie Yuan, Jun Wang, Mingzhao Chen, Markus Zirnheld, Rockwell T. Li, Yuan Zhang, Yiming Li, Pingshan Wang

College of Sciences Posters

Metal-organic macrocycles have received increasing attention not only due to their versatile applications such as molecular recognition, compounds encapsulation, anti-bacteria and others, but also for their important role in the study of structure-property relationship at nano scale. However, most of the constructions utilize benzene ring as the backbone, which restricts the ligand arm angle in the range of 60, 120 and 180 degrees. Thus, the topologies of most metallo-macrocycles are limited as triangles and hexagons, and explorations of using other backbones with large angles and the construction of metallo-macrocycles with more than six edges are very rare.

In this study, …

Clostridioides Difficile Spore Production In Response To Antibiotic And Immune Stress, Adenrele Oludiran, Erin B. Purcell

College of Sciences Posters

Clostridioides (Clostridium) difficile, an anaerobic, spore-forming Gram-positive pathogenic bacterium, is a major cause of hospital-acquired infections and can persist as surface-attached biofilms for protection from antibiotic and immune stress. C. difficile can form biofilms as a single species or with other anaerobic intestinal bacteria. The environmental signals that cause individual cells to secrete toxins, form biofilms, or develop into spores that can spread the infection to new patients are unknown. In these studies, we investigate bacterial responses to different stress. Antimicrobial host-defense peptides (HDPs) produced by animal immune systems are promising candidates to develop novel therapies for bacterial infection …

Influence Of Monovalent And Divalent Ions In The Conformational Change Of Caspase-Cleaved Par-4 (Cl-Par-4) Tumor Suppressor Protein, Krishna K. Raut, Komala Ponniah, Steven M. Pascal

College of Sciences Posters

Prostate apoptosis response-4 (Par-4) is a pro-apoptotic tumor suppressor protein. We have shown that this 38 kDa full-length Par-4 (Fl-Par-4) protein is predominantly intrinsically disordered in vitro. In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate a 24 kDa functionally active cleaved Par-4 (cl-Par-4) fragment. The cl-Par-4 protein inhibits the NF-κB-mediated cell survival pathway and causes selective apoptosis in various tumor cells. Our laboratory is interested in how the disorder-order balance within Fl-Par-4 and cl-Par-4 may be related to the balance between cell survival and cell death. Currently, we are using biophysical techniques such as circular …

Sulfur Dioxide From The Atmospheric Chemistry Experiment Satellite, Doug Cameron

College of Sciences Posters

The version 4.0 dataset from the Atmospheric Chemistry Experiment – Fourier Transform Spectrometer (ACE-FTS) on SCISAT, released in March of 2019, has sulfur dioxide (SO₂) volume mixing ratio (VMR) profiles as a routine data product. From this dataset, global SO₂ distributions between the altitudes of 10.5 km and 23.5 km are analyzed. The global distribution of all SO₂ VMR data by altitude is broken down into 30° and 5° latitude zones. Seasonality of the global SO₂ distribution is explored. Volcanic SO₂ plumes are isolated in the dataset and compared with extinction data from the …