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Full-Text Articles in Physical Sciences and Mathematics
Increasing The Efficacy Of Doxorubicin Against Breast Cancer, Jovana Hanna, Jung-Suk Choi
Increasing The Efficacy Of Doxorubicin Against Breast Cancer, Jovana Hanna, Jung-Suk Choi
Undergraduate Research Posters 2018
In the United States, breast cancer accounts for one in three cancer diagnoses in women, making it the most common type of cancer in women. One important chemotherapeutic agent used to treat breast cancer is doxorubicin, an anthracycline compound that causes cell death by damaging DNA in addition to producing reactive oxygen species. Previously, the Berdis lab developed an artificial nucleoside analog designated 5-NIdR that improves the efficacy of DNA damaging agents used against brain cancer. This nucleoside works by inhibiting the replication of damaged DNA created by certain chemotherapeutic agents. In this project, we tested the ability of 5-NIdR …
Synthesis Of Sialic Acid Derivative For Modifying Cell Surface Sialylation, Isaac Turan, Joseph Keil
Synthesis Of Sialic Acid Derivative For Modifying Cell Surface Sialylation, Isaac Turan, Joseph Keil
Undergraduate Research Posters 2018
The exterior of cell surfaces express a dense layer of glycans which are often terminated by sialic acid (SA). SA is an acidic monosaccharide whose presence is found on the terminal ends of glycans of either glycoproteins or glycolipids. Due to its hydrophilic and electronegative nature, SA is often involved in both physiological and pathological processes, such as in regulating cellular interactions with ligands, microbes and neighboring cells. In addition to these functions, SA is also implicated in controlling cellular activation, differentiation, transformation and migration. Cell surface glycometabolic engineering provides a useful tool to remodel cell surface SA. In this …
Tmco1 Is A Novel Target For Cancer Chemotherapy, Ashley Przybylowicz, Ruhan Wei, Qiaoyun Zheng
Tmco1 Is A Novel Target For Cancer Chemotherapy, Ashley Przybylowicz, Ruhan Wei, Qiaoyun Zheng
Undergraduate Research Posters 2018
Transmembrane and coiled-coil domains 1 (TMCO1) is a protein of 22 KDa highly conserved in amino acid sequence among mammalian species and functions as an endoplasmic reticulum (ER) Ca2+load-activated Ca2+channel. Homozygous frameshift mutation in TMCO1 causes distinctive craniofacial dysmorphism, skeletal anomalies, and mental retardation. However, its physiological functions are largely unknown. In this study, we found that TMCO1 was co-localized with microtubules as determined by immunohistostaining and a co-sedimentation assay. Interestingly, TMCO1 was highly expressed in the invasive front of high grade lung cancer and metastatic cancer cells of clinical specimens. To further investigate the biological role of TMCO1 in …
Anti-Thrombotic Coatings For Blood Contacting Medical Decives And Implants Based On Nitric Oxide Release, Celine El-Khoury, Shaimaa Maher, Haitham Kalil
Anti-Thrombotic Coatings For Blood Contacting Medical Decives And Implants Based On Nitric Oxide Release, Celine El-Khoury, Shaimaa Maher, Haitham Kalil
Undergraduate Research Posters 2018
Blood-contacting medical devices, are often used to treat cardiovascular diseases. These implantable medical devices, even if labeled as biocompatible, can cause serious complications in patients. Thrombus formation and infection are the main causes of failure of these devices. In contrast to the healthy endothelium, which actively resists thrombosis, artificial surfaces promote clotting through a complex series of interconnected processes that include protein adsorption, adhesion of platelet, leukocytes and red blood cells, ending with thrombosis. Using a layer-by-layer thin film building strategy to form layers of polyethyleneimine (PEI) and iNOSoxy as NO-releasing coatings allows for assembly of multi-component protein/PEI films. Here, …
Dodecanedioic Acid Treatment In Vlcad Fibroblasts, Igor Radzikh
Dodecanedioic Acid Treatment In Vlcad Fibroblasts, Igor Radzikh
Undergraduate Research Posters 2018
Very-long-chain acyl-CoA dehydrogenase deficiency is the second most common disorder of fatty acid oxidation in the USA, with an incidence of 1:25,000-1:100,000 newborns (Tucci, Floegel, Beermann, Behringer, Spiekerkoetter, 2017, pg. 196). The current dietary therapeutic strategies are designed to avoid long chain fatty acids, instead providing carbohydrates and medium chain triglycerides as an energy source. Despite the controlled and biochemically balanced diet, it has a limited success in treatment of clinical symptoms and metabolic decompensations in VLCAD affected individuals. It has been proposed that defect in long chain fatty acids catabolic pathway leads to the severe energy deficiency, that primary …
Off Targets Toxicological Investigation Of Anti-Cancer Tubulin Inhibitors, Abbound Sabbagh, Yaxin Li
Off Targets Toxicological Investigation Of Anti-Cancer Tubulin Inhibitors, Abbound Sabbagh, Yaxin Li
Undergraduate Research Posters 2018
We have developed a class of novel tubulin inhibitors based on NSC751382 (Figure 1), Benzo[1,3]dioxole-5- carboxylic acid [3-(2,5-dimethyl- benzyloxy)-4- (methanesulfonyl-methyl-amino)-phenyl] -amide, as the lead compound. This compound showed potent tubulin polymerization inhibitory activity by binding at the colchicine’s binding domain, and suppressed cancer cell growth with an IC50 of 200nM. It has molecular weight of 482, logP of 4.1, only one hydrogen bond donor, and eight hydrogen bond acceptors. The compound meets the Lipinski's Rule of Five and is a highly drug-like molecule. In addition, NSC751382 significantly inhibited the growth of Taxol resistant cancer cells, suggesting it is not a …