Physical Sciences and Mathematics Commons^™

Towards Personalized Medicine: Computational Approaches For Drug Repurposing And Cell Type Identification, Azam Peyvandipour

Wayne State University Dissertations

The traditional drug discovery process is extremely slow and costly. More than 90% of drugs fail to pass beyond the early stage of development and toxicity tests, and many of the drugs that go through early phases of the clinical trials fail because of adverse reactions, side effects, or lack of efficiency. In spite of unprecedented investments in research and development (R&D), the number of new FDA-approved drugs remains low, reflecting the limitations of the current R&D model.

In this context, finding new disease indications for existing drugs sidesteps these issues and can therefore increase the available therapeutic choices at …

Learning From Heterogeneous Data, Lu Wang

Wayne State University Dissertations

Data with both heterogeneity and homogeneity is now ubiquitous due to the development of multitudinous data collection techniques. To encode the data heterogeneity and homogeneity, we focus on unsupervised and supervised learning approaches. In unsupervised learning, to consider both data heterogeneity and homogeneity, we develop three clustering frameworks to maximize the heterogeneity among data sub-groups and homogeneity within each data sub-group for over-dispersed data in three different data types, i.e., alphabetic, network and mixed feature types data. In supervised learning, the traditional approaches, however, either build a global model for a whole group including all sub-groups, which fail to consider …

Deep Learning Methods For Visual Object Recognition, Zeyad Hailat

Wayne State University Dissertations

Convolutional neural networks (CNNs) attain state-of-the-art performance on various classification tasks assuming a sufficiently large number of labeled training examples. Unfortunately, curating sufficiently large labeled training dataset requires human involvement, which is expensive, time-consuming, and susceptible to noisy labels. Semi-supervised learning methods can alleviate the aforementioned problems by employing one of two techniques. First, utilizing a limited number of labeled data in conjunction with sufficiently large unlabeled data to construct a classification model. Second, exploiting sufficiently large noisy label training data to learn a classification model. In this dissertation, we proposed a few new methods to mitigate the aforementioned problems. …

Novel Machine Learning Methods For Modeling Time-To-Event Data, Bhanukiran Vinzamuri

Wayne State University Dissertations

Predicting time-to-event from longitudinal data where different events occur at different time points is an extremely important problem in several domains such as healthcare, economics, social networks and seismology, to name a few. A unique challenge in this problem involves building predictive models from right censored data (also called as survival data). This is a phenomenon where instances whose event of interest are not yet observed within a given observation time window and are considered to be right censored. Effective models for predicting time-to-event labels from such right censored data with good accuracy can have a significant impact in these …