Physical Sciences and Mathematics Commons^™

Machine Learning Approach For Prediction Of Bone Mineral Density And Fragility Fracture In Osteoporosis, Bibek Bhattarai

UNLV Theses, Dissertations, Professional Papers, and Capstones

Osteoporosis is a prevailing bone disease, which weakens the bone and is one of the

major factors of disability, especially in elderly persons. In this thesis, we developed

various machine learning models to predict fracture risk of osteoporosis. These mod-

els were built to base their predictions on genotype and phenotype data of patients.

We performed two dierent types of analysis: fracture risk prediction (a classica-

tion model) and bone mineral density (BMD) prediction (a regression model). For

fracture risk prediction we implemented four dierent algorithms: logistic regression,

random forest, gradient boosting, and multi-layer perceptron (MLP) based on dier-

ent …