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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Bioactive Heterocycles, Shaila Akter Shetu
Synthesis Of Bioactive Heterocycles, Shaila Akter Shetu
Theses and Dissertations
The Discovery of a variety of heterocyclic drugs for the treatment of cancer and other diseases (e.g, neglected tropical diseases) is a medical breakthrough and inspiring for the research community as a whole. A wide range of natural, semi-synthetic, and synthetic anticancer drugs are synthesized using various methods. Among them, β -lactams stand out as a novel class of antibiotics that has different types of biological as well as anti-cancer properties. β -lactam has become a premier and active research subject towards the development of revolutionary anti-cancer drugs. In recent years, a large amount of investigations have been done to …
Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt
Understanding The Complexities Of Anemia In Chronic Inflammatory Diseases From Diagnosis To Treatment, Naomi Rae Flindt
Theses and Dissertations
Iron is an essential nutrient for energy and DNA replication. Its homeostasis is commonly perturbed by chronic inflammatory mechanisms. Chronic inflammation upregulates a cytokine, hepcidin, that degrades the iron export protein ferroportin. Without a way to export iron into the bloodstream iron availability in blood becomes depleted. Iron depletion in the blood stream hinders erythropoiesis and is termed anemia. Herein I investigate and inhibit the mechanism of hepcidin activation. Inhibition of hepcidin activation has released iron from tissues and alleviated anemic conditions in a cancer model. I have laid the foundation to investigate this pathway in a 3D spheroid model. …
Mechanisms And Impact Of Hypoxia Regulated Inhibins In Cancer, Ben Allen Horst
Mechanisms And Impact Of Hypoxia Regulated Inhibins In Cancer, Ben Allen Horst
Theses and Dissertations
Inhibins are heterodimeric ligands within the TGFβ superfamily, comprised of an α-subunit (INHA) and a β-subunit (either INHBA or INHBB) with emergent roles in cancer. Inhibins are biomarkers of disease burden and prognosis in a subset of cancers and utilize the coreceptors betaglycan (TGFBR3) and endoglin (ENG) for physiological or pathological outcomes. Previously, we found inhibin promotes angiogenesis in ovarian cancer however no mechanism of regulation for inhibin expression in cancer has been established. Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. …
The Activity Of Qh Ii 66 And It’S Analogs In Medulloblastoma, Melanoma And Non-Small Cell Lung Cancer Cell Lines., Taukir Ahmed
The Activity Of Qh Ii 66 And It’S Analogs In Medulloblastoma, Melanoma And Non-Small Cell Lung Cancer Cell Lines., Taukir Ahmed
Theses and Dissertations
GABAARs (gamma-aminobutyric acid type A receptors) are transmembrane pentameric ligand-gated chloride ion channels that respond to GABA, the central nervous system's principal inhibitory neurotransmitter (CNS). The benzodiazepines (BZDs) bind between the GABAAR α+γ2-subunits at their extracellular interface. The binding of ligands to distinct subunits of GABAA receptors, notably the α1-6β2/3γ2 ion channels, can have a wide range of effects on brain activities. The sedative, ataxic, amnesic, anticonvulsant, and addictive actions of GABAARs' α1-subtype selective ion channels should be avoided, except for the anticonvulsant and anxiolytic effects, while creating ligands for this BZ allosteric modulatory site. Many studies have linked the …