Physical Sciences and Mathematics Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Random Search Plus: A More Effective Random Search For Machine Learning Hyperparameters Optimization, Bohan Li

Masters Theses

Machine learning hyperparameter optimization has always been the key to improve model performance. There are many methods of hyperparameter optimization. The popular methods include grid search, random search, manual search, Bayesian optimization, population-based optimization, etc. Random search occupies less computations than the grid search, but at the same time there is a penalty for accuracy. However, this paper proposes a more effective random search method based on the traditional random search and hyperparameter space separation. This method is named random search plus. This thesis empirically proves that random search plus is more effective than random search. There are some case …

Developing Leading And Lagging Indicators To Enhance Equipment Reliability In A Lean System, Dhanush Agara Mallesh

Masters Theses

With increasing complexity in equipment, the failure rates are becoming a critical metric due to the unplanned maintenance in a production environment. Unplanned maintenance in manufacturing process is created issues with downtimes and decreasing the reliability of equipment. Failures in equipment have resulted in the loss of revenue to organizations encouraging maintenance practitioners to analyze ways to change unplanned to planned maintenance. Efficient failure prediction models are being developed to learn about the failures in advance. With this information, failures predicted can reduce the downtimes in the system and improve the throughput.

The goal of this thesis is to predict …

On The Role Of Genetic Algorithms In The Pattern Recognition Task Of Classification, Isaac Ben Sherman

Masters Theses

In this dissertation we ask, formulate an apparatus for answering, and answer the following three questions: Where do Genetic Algorithms fit in the greater scheme of pattern recognition? Given primitive mechanics, can Genetic Algorithms match or exceed the performance of theoretically-based methods? Can we build a generic universal Genetic Algorithm for classification? To answer these questions, we develop a genetic algorithm which optimizes MATLAB classifiers and a variable length genetic algorithm which does classification based entirely on boolean logic. We test these algorithms on disparate datasets rooted in cellular biology, music theory, and medicine. We then get results from these …