Physical Sciences and Mathematics Commons^™

Aromatic Amine--Haloboranes : Evidence For Trigonal Boronium Cations, Debra H. Reid

Master's Theses

In the last twenty years Lewis adducts of boron trihalides and mixed boron trihalides have been examined using nuclear magnetic resonance spectroscopy. The donor to which the boron trihalide attaches has generally been some type of amine (strong donor), though oxygen, sulfur, phosphorous, and other donors ahve also been studied. The boron trihalide portion serves as the Lewis acid. Various nuclei (1H, 13C, 15N, 11B, 19F) have been examined in such boron trihalide adducts and the general trend in signal position in all 5 nuclei observed is (in order of increasing downfield shift) BF3

The acid strength of the boron …

Isolation And Characterization Of The Serum Ferroxidase Inhibitor, Melissa Page Calisch

Master's Theses

strong evidence suggests that the serum ferroxidases (ceruloplasmin andferroxidase II) promote the formation of Fe-III transferrin and thereby stimulate the turnover of iron from tissue stores. Ceruloplasmin is the major ferroxidase in human serum; whereas, ferroxidase II accotmts for an increased proportion of the activity in less highly developed animals. A large fold increase in total ferroxidase II activity was observed when both human and rabbit sera were subjected to gel-filtration on sephadex G-200. This indicated that whole serum might contain a potent inhibitor of ferroxidase II. Such an inhibitor has been isolated and purified to homogeneity by a combination …

The Investigation Of 3,4- Dipheny1-3- Cyclobutene-1, 2-Dione As A Precursor To A Bis-Ketene, John Dana Myers

Master's Theses

The purpose of this research is to investigate the use of 3, 4-diphenyl-3-cyclobutene-1, 2-dione as a synthetic precursor to bis-ketenes and ultimately examine the chemical behavior of this relatively unknown system. We intend to investigate some of the chemical behavior of bis-phenylketene produced by the well-documented photochemical ring opening of 3, 4-diphenyl-3-cyclobutene-1, 2-dione. Specifically the use of alkenes a chemical traps for the bis-ketene will be investigated. These reactions will be compared and contrasted to the behavior of the ketenes and vinyl ketenes.

An Fe (Iii) - Initiated Oxidase Reaction With Ferroxidase-Ii, Glenn Alexander Hegamyer

Master's Theses

A reaction involving iron as an intermediary electron carrier for the coupling of electron transfer from an endogenous substrate to ferroxidase-I has been proposed.

The enzymic nature of the reacti on has been established and studies with iron chelating agents have demonstrated the involvement of Fe(III). The kinetic parameters of ferroxidase-11 with Fe (lll) were found to be quite similar to those previously established for Fe(Il). The participation by the copper associated with ferroxi dase-11 was ascertained by use of the copper chelating agent, diethyl -di thio-carbamate .

A variety of substances normally found in blood were surveyed as possible …

The Synthesis Of Some Potential Antimalarials : The 3-(4- Choloropheny1) -5, 7- Dichloronaphthylaminoalcohols, Dwight Allen Shamblee

Master's Theses

A new scheme is presented for the preparation of 3~(4-chlorophenyl)-5,7-dichloro-l-methylnaphthalene, from which, four derivatives, 3~(4-chlorophenyl)-~-di(n-butyl)aminomethyl~5,7-dichloro-l-naphthalene-methanol hydrochloride, 3-(4-chlorophenyl)-5,7-dichloro-~-(2-piperidyl)-1-naphthalenemethanol acetate, l-[3-(4-chlorophenyl)-5,77dichloro-lnaphthyl]-3-di(n-butyl)aminopropanol hydrochloride, and 1-[3-(4-chlorophenyl)-5, 7-dichloro-l-naph,thyl]-2-(2-piperidyl) ethanol hydrochloride, were prepared. These four derivatives were submitted to Walter Reed Army Institute of Research for. the determination of their potential as antimalarial agents.

A Study Of The Electrolytic Oxidation Of Antioxidants At A Stationary Platinum Microelectrode, Mark Anthony Forte

Master's Theses

Phenolic antioxidants have a Wide variety of uses. They are em- ployed to prevent oxidative and thermal degradation of everything from plastics to foodstuffs. They may even have potential as carcinostatic agents. In general, they act as chain terminators in free radical type reactions.

An Atomic Absorption Method For Determining Micromolar Quantities Of Primary Aliphatic Amines In The Presence Of Secondary And Tertiary Aliphatic Amines, Nathalie Harwood Perkins

Master's Theses

A method for the determination of primary aliphatic amines in the presence of secondary and tertiary amines is described. The primary amine is reacted wit ha complexing reagent containing cupric chloride, salicylaldehyde and triethanolamine. The copper complex formed is extracted into 10% hexanol in toluene. The amount of copper in the toluene layer is determined by atomic absorption spectroscopy. This is a measure of the primary amine in the sample. The method can be successfulyl applied to both monoamines and diamines as well as an amino alcohol. Data for the analysis is + 0.05% at the 2% level and below. …

Photochemical Behavior Of Some Nitrogen Heterocyclics, James Wesley Harris

Master's Theses

The compounds, 3,6-dimethoxypyridazine, l,2-dimethyl- 3,6(1H,2H)-pyridazinedione, and 6-methoxy-2-methyl-3(2H)­ pyridazinone, were prepared by using reported preparations. Their photochemistry was investigated and compared to the thermal chemistry and photochemistry of maleic hydrazide.

Synthesis And Selected Reactions Of [Pi]-(Arene) Chromium Tricarbonyls, Anthony L. Scaggs

Master's Theses

This project was concerned wit hthe preparation of two pi-(arene)-chromium tricarbonyl compounds that could serve as a synthetic intermediates to more complex systems. These intermediates would be particularly well-suited for the preparation of mono-complexed diaryl compounds. The two intermediates selected were pi-(acetophenone) chromium tricarbonyl and pi-(benzyl bromide) chromium tricarbonyl. After the intermediates had been synthesized, their utility in several selected reactions was to be examined.

Aromatic Solvent Induced Shifts Of Trifluoromethyl Pyrazoles, Manuel Constantine Bourlas

Master's Theses

Nuclear Magnetic Resonance (NMR) has been used to study the keto-enol equilibrium in a number of trifluoro­methyl S-diketones as well as the dihydropyrazoles obtained when these S- diketones are reacted with thiosemicarbazide. The technique of Aromatic Solvent-Induced Shifts (ASIS) has been used to study the geometry of the collision complex and the strength of the association between solute and solvent. From the data presented, the stereochemistry of these pyrazoles has been determined and a reaction mechanism for their formation has been proposed.

Ferroxidase-Ii: A Blood Serum Lipo-Protein, Christine Shih Ming Sung

Master's Theses

Ferroxidase-II was definitely identified as a lipoprotein. Cholesterol and phospholipids remained tightly associated with the ferroxidase-II protein following extensive purification. Quantitative analysis showed that it is a high-density lipoprotein. Thin-layer chromatographic analyses indicated that phosphatidylcholine accounts for the majority of the bound phospholipid with lysophosphatidyl choline and sphingomyel in accounting for the remaining phospholipid.

Treatment of purified ferroxidase-II with phospholipase C or A resulted in a loss of ferroxidase activity which paralleled the hydrolysis of phospholipid. Phospholipid D treatment also resulted in the loss of ferroxidase activity, yet the loss was not as great as with other phospholipases. A lipid-depleted …

Principles Of Control Theory As Applied To A Thermostat, Joseph Peter Stidham

Master's Theses

The recent development of solid state electronics has opened new possibilities in instrumentation design. One development has been the availability of compact, low cost, high gain, D. C. amplifiers which can be used in the design and construction of sensitive laboratory instruments (11). Using these amplifiers a thermostat capable of precise control can be constructed and its performance compared with the performance expected by an analysis of the closed loop control equations.

A Correlation Of The Idealized Heat Of Vaporization To Molecular Weight, Harold Earl Bennett

Master's Theses

Using the Clausius-Clapeyron equation as a base, many investigators have tried to develop variations to better describe both ideal and non-ideal systems. The literature is abundant with correlations of vapor pressure to temperature and associated correlations of latent heats of vaporization to molecular characteristics; often molecular weight or carbon number.

Chelation Of Two Polyhydroxyamines With Copper (Ii) Ion, David H. Powell

Master's Theses

Two polyamines, 2,8-bishydroxymethyl-2,8-dimethyl- 3, 7-diaza-1,5,9-nonanetriol and 2,8-bishydroxymethyl-2,8- dimethyl-3,7-diaza-l,9-nonanediol, were prepared and the coordination of these compounds with Cu (II) ions in solution was investigated. Spectrophotometric study of the solutions of these compounds gives evidence of the formation of two complexes, containing one mole of ligand per metal ion and two moles of ligand per metal ion, respectively. The two stability constants for these complexes and the basicity constants for these ligands were calculated from potentiometric titrations at 30°C. A compadson of the stabj lity constants and basici ty cons tan ts for the two compounds was made to determine the …

A Study Of The Kinetics Of Light Induced Modulation Of Absorption In Zinc Selenide, Herbert Seth Berman

Master's Theses

No abstract provided.

A Spectrophotometric Study Of The Reaction Between Benzoyl Peroxide And N, N-Dimethyl-P-Phenylenediamine, Bertha Cosby King

Master's Theses

A special need for methods to determine low concentrations of organic peroxides originated because of their hazardous and harmful effects, Even the small amounts of organic peroxide formed by autoxidation in ethers exposed to air make the ethers highly explosive and unsuitable for use as anesthesia or laboratory solvents. The formation of organic peroxides in fats and oils causes rancidity. They have been named as pollutants, and some of them are known to have detrimental physiological effects.

The purpose of this research was to improve this method of analysis and to determine better conditions for the measurement of color by …

A Study Of A Divalent Cation-Selective Electrode, William Stanhope Ryan Jr.

Master's Theses

The ion-selective membrane electrode, recently introduced commercially, has shown excellent promise as a tool for determining ionic activities and concentrations in solution. It was the intent of the author to study the Orion divalent cation-selective electrode with two objectives.

The first objective of this research was to characterize the response of the divalent cation-selective electrode to calcium and magnesium ions in aqueous solutions. The effect of anions, monovalent cations; and pH upon this response was investigated. An examination was made of the response of this electrode to other divalent cations and of the effect of organic solvents on the membrane …

Laser Induced Optical Modulation In Zinc Selenide, Donald Edward Everett

Master's Theses

The experiments reported here with zinc selenide have a two-fold purpose. First, by using basically the same experimental set-up as Conway did, we are attempting to duplicate this LIMA using zinc selenide instead of cadium sulfide. Unlike his set-up, primarily one laser chopping frequency was used. Also, only one laser wavelength, 632.8 nanometers, was available, where Conway used lasers of wave­ lengths 647.1 nanometers and 530.8 nanometers. Another main difference is that in earlier works by Conway, laser pulse duration was of the order of 40 milliseconds, whereas the present duration is approximately 2.5 milliseconds. It was observed that the …

A Study Of The Acetic Anhydride Method For The Determination Of Citric Acid, Russell Kent Odland

Master's Theses

Citric acid is an important compound of many systems. Numerous methods, both qualitative and quantitative, have been used for the determination of the compound. Some of the biological systems investigated include fermentation studies, action on yeasts, antioxidant in fruits, additive in bakery goods and salad dressing preparations, amounts in vegetables, and others.The above examples are not complete; they only show the varied applications of citric acid. The purpose of this project was to investigate a quantitative spectrophotometric method using anhydrous conditions based on the citric acid-acetic anhydride-pyridine reaction. Conditions affecting the reaction were investigated and optimized for maximum sensitivity and …

Synthesis Of Chromium Tricarbonyl Complexes Of 1,3-Diaryl-2-Propyl Methanesulfonates, Ashby French Johnson

Master's Theses

Various unsymmetrically substituted 1 , 3-dipheny l -2- propylmethanesulfonates were prepared and complexed with chromium hexacarbonyl. The major products obtained from this complexation contained one rr -complexed ring and the other ring substituted with more common groups.

Substituted ℓ-Dialkylaminomethyl-3-Phenyl-1-Naphthalenemethanols, Richard Elroy Davis

Master's Theses

Malaria is still a world health problem. Established antimalarial drugs have become ineffective in many areas because of the emergence of resistant strains of malaria. New efforts have been initiated to study variations of new untried compounds and earlier structures shown to have activity. The 4-quinolinemethanols fall into the latter class. The great activity of the 4-quinolinemethanols is offset by their phytotoxic activity.

The possibility that substituted o(-dialkylaminomethyl-3-phenyl-1- naphthalenemethanols, as analogs of the 4-quinolinemethanols, would be effective antimalarials, yet not have the phototoxic side effect, is discussed in this paper. Synthetic pathways to the naphthalenemhethanols are discussed. Experimental procedures are …

Data Retrieval In Mass Spectrometry By An Optical Coincidence System, Cynthia Helmintoller O'Donohue

Master's Theses

The object of this work was to develop an information storage and retrieval system for use in mass spectroscopy. The information to be stored was the compound's name, the mass spectrum, and distinctive physical and chemical properties. It was desirable that the system be one that could be used in the mass spectral laboratory. At the time this project was initiated, no system for mass spectroscopy had been developed with the characteristics of simplicity, rapid retrieval, and practicality of use in the laboratory without elaborate and space consuming equipment. Thus, a system was needed to aid the laboratory personnel in …

An Attempt To Measure The Diffusion Of Aluminum Into Natural Aluminum Oxide, Charles Edward Galaspie

Master's Theses

The goal of this research was to investigate the diffusion of aluminum ions in natural aluminum oxide grown under atmospheric conditions. The basis for the approach employed here had been developed earlier by J. H. Christian and H. L.Taylor. However, these authors studied the diffusion of aluminum ions in an oxide grown in a pure oxy­gen atmosphere. They utilized a glass slide upon which aluminum metal was deposited in vacuo (10^-11 Torr). Oxide was then allowed to grow on this metal by back-filling the vacuum with pure oxygen to a pressure of 40 to 50 m Torr while infrared …

Peracid Oxidation Of 3-Phenylindene, Christopher Peter Johnson

Master's Theses

Indene oxide (indan, 1,2-epoxy; indene 2,3-oxid is first recorded in the literature in 1919. This compound was formed in practically quantitative yield by the treatment of indene bromo­ hydrin in ether with powdered potassium hydroxide. At this time Van Loon also reported the preparation of indene oxide by mechanical shaking of an anhydrous, ethere!al solution of the bromohydrin with finely powdered potassium hydroxide. The desired product was obtained in a 92-97% yield by this method. Indene oxide has been prepared in a similar manner from trans-2-chloro-l-indanol by treatment "with soda," distillation of the acetone in vacuo after 15 hours, and …

A Thermogravimetric Study Of Polyvinylidene Chloride In Polymers, Charles Edward Singleton

Master's Theses

In the manufacturing of thin films such as cellophane, polymers employed as coatings greatly improve film functionality. Polymers such as polyvinylidene chloride, polyvinyl chloride, polyvinyl acetate and many others are used as coatings or components of coatings designed to improve the functionality of a film. Selection of polymers with properties that will meet the requirements of the finished film product is a continuing process of film manufacturers. Physical and chemical characterization of the polymer along with coating functionality are the factors involved in the selection. Chemical composition is the most important factor affecting polymer characteristics and must be known if …

The Theory And Development Of A Dyeing Machine Employing The Rotary Pendulum, Ashley Paul Smith

Master's Theses

A review of dyeing methods for carpet is made with the objective that the requirements of a new machine could be formulated. The proposal for a new machine is made in the light of the above review using a pendulum as the basic component. A theory is developed for the motion of the pendulum which is mounted on a rotating disc, and the experimental work built on theory is outlined. A prototype machine based on the rotary pendulum mechanism was used to dye impregnate carpet.

A Spectrophotometric Study Of The System: Cobalt--2,2,8,8-Tetrakis (Hydroxymethyl)-3,7-Diaza-1,5,9-Nonanetriol, Pauline Frances Fones

Master's Theses

Spectrophotometric studies or solutions or 2,2;8;a. tetrakis(hydroxymethyl)-3, 7-diaza-1,5.9-nonanetriol, (HOCH₂),₃CHNCH₂CH(OH)CH₂NHC(CH₂OH)₃, with cobalt (II) gave evidence of complexes having metal-ligand ratios of 1:2 and 1:3. Complexation appeared nearly complete at pH 8 or greater. Between pH 8 and pH 11, the positions of the maxima in the absorbance spectra remained essentially constant and no precipitation was observed. The 1:2 complex formed rapidly, while the 1:3 complex formed more slowly, requiring one to two weeks to reach equilibrium, after which the solutions remained unchanged over a period or several months. Evidence …

A Qualitative Study Of The "Bohlmann Band", John Alfred Richman Jr.

Master's Theses

This thesis is concerned with a qualitative study of the "Bohlmann Band", a result of C-H stretching frequencies, which is often observed in the 3.57 to 3.70 μ region in the infrared absorption spectra of amines. The appearance of this band is characteristic of tertiary amines although a few exceptions have been encountered.

A Method For The Determination Of Trace Metals In Carbon By Atomic Absorption Spectroscopy, Leo Francis Meyer

Master's Theses

The object of this research was to develop an accurate, rapid and economical method for determining trace amounts of metals in carbons, especially in activated carbons designed as gas adsorbents. More specifically, the investigation was directed primarily to the determination of K, Ca, and Fe in Carbons

Potential Neoplasm Inhibitors Ii, Ronald Lee Floyd

Master's Theses

No abstract provided.