Physical Sciences and Mathematics Commons^™

Preparation Of Organofluorine Compounds: Exploring Mono-, Di-, And Tri-Fluorination, Diandra M. Rudzinski

Master's Theses

Organofluorine compounds exhibit biological activity and have advantageous properties for drug design. Natural occurring fluorinated molecules are rare, demanding new synthetic methods for their preparation. A novel route to access trifluoromethyl ketones from Weinreb amide precursors is discussed. This is the first documented method for the use of the Ruppert-Prakash reagent, (trifluoromethyl)trimethylsilane, for the production of trifluoromethyl ketones from amide starting materials. This method is tolerant of aryl and alkyl substrates exhibited by their moderate to excellent yields. A discussion of the unusual reactivity of these amides, their selectivity for mono-trifluoromethylation, and other mono-, and di-fluorination attempts are reported.

Ultra-Stable Protein-Polymer Bioconjugates, Kyle S. Cole

Master's Theses

No abstract provided.

Preparation Of Nitrogen-Containing Heterocycles Via Cyclization Of Pyridine-Tethered Organolithiums, Elizabeth Archer

Master's Theses

No abstract provided.

Design And Synthesis Of Fluorescence Turn-On Probes For Iron, Randy K. Jackson

Master's Theses

No abstract provided.

An Economic Analysis Of Wine Grape Production In The State Of Connecticut, Jeremy L. Jelliffe

Master's Theses

The Connecticut Wine and Vineyard industry has grown at a steady 3.9% per year over the past decade (ATTTB, 2009). Economic models estimate that the wineries sub-sector contributes $38 million dollars to the state economy and direct employment of 106 residents (Lopez et al., 2010). Programs to support and foster further growth of the industry and CT farm vineyard culture include the Department of Agriculture’s CT Wine Trail and the annual CT Wine festival (DOAG, 2010). Farmland preservation groups also support vineyard development since grape growing tends to secure tracts of farmland for long periods of time.

Investment analysis for …

Movement, Habitat Use And Detection Probability Of Bridle Shiner Estimated By Patch Occupancy Modeling In A Connecticut Watershed, Timothy Jensen

Master's Theses

The bridle shiner (Notropis bifrenatus) is believed to have once been an important prey item throughout its native range; however, recent reports suggest populations have declined significantly and the species is now widely considered as imperiled. Habitats that are associated with this species are typically difficult to sample using traditional methods, making it unclear how much of the observed range reduction could be actual or perceived. My objectives were to estimate detection probability of bridle shiner, evaluate the importance of habitat on their distribution, and determine patterns of movement among habitat patches. I employed a repeated surveys design …

Weierstrass Points On Families Of Graphs, William D. Lindsay Jr.

Master's Theses

No abstract provided.

Synthesis Of Half-Loaded Nitroimidazole Indocyanine Green Dyes Attached To Carbon Nanotubes, Courtney L. Stanford

Master's Theses

Indocyanine green dye is the only FDA approved NIR fluorescent dye that can be used in humans. 2-Nitroimidazoles are very effective radiosensitizers, have low cytotoxicity, and target hypoxic tissue. By coupling the two together, hypoxic tumors can be targeted and imaged. Previous work has been done to couple 2-nitroimidazole to both sides of the indocyanine green dye. This work focuses on expanding that concept to couple 2-nitroimidazole to only one side of the dye, thus allowing for the other end to be available to couple to another compound, generating a half loaded 2-nitroimidazole indocyanine green dye. In theory, this half-loaded …

Fluorescence Tagging Of Marine Low Molecular Weight Carboxylic Acids, Brian C. Gismervik

Master's Theses

This thesis aims at the evaluation of the best amide bonding strategy that places a fluorescence aminomethyl coumarin tag onto a LMW organic acid in aqueous solution. A three-stage study was conducted. First, a suitable aminomethyl coumarin fluorophore was synthesized. Second, a library of acid-derivatized standards was synthesized for use in optimizing the anticipated HPLC separation of a mixture of LMW acids expected to be found in marine samples. Third, the aforementioned amide coupling strategies were screened to identify the most applicable method for our reaction conditions to the tagging of LMW organic acids in a large number of field …

Investigation Of Trends And Predictive Effectiveness Of Crash Severity Models, James E. Mooradian

Master's Theses

This thesis describes analysis using ordinal logistic regression to uncover temporal patterns in the severity level (fatal, serious injury, minor injury, slight injury or no injury) for persons involved in highway crashes in Connecticut, focusing on the demographic split between senior travelers (65 years and over) and non-senior travelers. Existing state sources provide data describing the time and weather conditions for each crash and the vehicles and persons involved over the time period from 1995 to 2009 as well as the traffic volumes and the characteristics of the roads on which these crashes occurred. Findings indicate an overall increase in …

Agent-Based Modeling Of Emergency Building Evacuation, Vi Q. Ha

Master's Theses

Panic during emergency building evacuation can cause crowd stampede, resulting in serious injuries and casualties. Agent-based methods have been successfully employed to investigate the collective human behavior during emergency evacuation in cases where the configurational space is extremely simple - usually one rectangular room - but not in evacuations of multi-room or multi-floor buildings. This implies that the effect of the complexity of building architecture on the collective behavior of the agents during evacuation has not been fully investigated. Here, we employ a system of self-moving particles whose motion is governed by the social-force model to investigate the effect of …

Computable Linear Orders And Turing Reductions, Whitney P. Turner

Master's Theses

This thesis explores computable linear orders through Turing Reductions and codes zero jump and zero double jump into linear orders using discrete, dense, and block linear relations.

The Synthesis Of A Homologous Series Of Alkyl Lumazines And Their Application To The Dispersion Of Carbon Nanotubes, William P. Kopcha

Master's Theses

In this thesis, the synthesis of a series of alkyl lumazine surfactants (LC_n) is reported. Their application to the dispersion of both CoMoCAT and HiPco single-walled carbon nanotubes (SWNTs) is examined in detail and the thermal stability and chirality selection properties of dispersions made with these surfactants were compared both between themselves and with an alkyl flavin surfactant (FC₁₂). Lumazine alkyl chain length exhibited some control over the quality and the quantity of SWNTs dispersed. LC₁₀ was deemed most appropriate for comparison with FC₁₂ based on considerations of solubility and nanotube individualization. …

Improved Synthesis Of The Longtailed Mealybug Pheromone, Johanna M. Bakonyi

Master's Theses

No abstract provided.

Bacterial Source Tracking Of E. Coli In A Constructed Wetland, Rose M. Martin

Master's Theses

Bacterial source tracking was used to identify sources of fecal contamination in a constructed wetland. Nucleotide sequence differences in the Escherichia coli malate dehydrogenase (mdh) gene were used to distinguish between strains isolated from pigeon and cattle feces. Fourteen E. coli isolates were taken from cattle and pigeon fecal samples and sixteen E. coli isolates were taken from wetland water samples. A region of the E. coli mdh gene was amplified via PCR and sequenced. Twelve distinct sequences were obtained. Water samples indicated the presence of both pigeon and cattle fecal contamination in the wetland. Six sequences distinct …

Testing The Limits Of Hyperspectral Airborne Remote Sensing By Mapping Eelgrass In Elkhorn Slough, Kelley J. Bostrom

Master's Theses

Seagrass ecosystems are a valuable resource, but vulnerable to changing conditions in the coastal ocean. Quantification of seagrass density and distribution from aerial imagery can be applied as a tool in resource management and ecosystem health and stability monitoring. This study investigates analytical methods for mapping eelgrass beds in an optically complex shallow, turbid estuary. Hyperspectral imagery (HSI) of Elkhorn Slough, CA was collected by the Spectroscopic Aerial Mapper with Onboard Navigation (SAMSON) instrument. In-situ data of water column and benthic optical properties and Hydrolight Radiative Transfer model were used to create a spectral library describing the reflectance of Elkhorn …

Collisional Reactivation Of Rift Margin Fracture Zones, Taiwan And The Taconic Allochthon, David C. Mirakian

Master's Theses

Chapter I. Transverse Topographic Development due to the Reactivation of a Partially-Subducted Fracture Zone: The Southwest Hsüehshan Range, Central Taiwan

Abstract — The southwest flank of the Hsüehshan Range is defined by a topographic break which cuts across regionally mapped structures in central Taiwan. The mountain front trends ~345°, slightly oblique to the Sanyi-Puli seismic zone which has been previously interpreted as a reactivated continental margin fracture zone. Structural data collected along the length of the topographic break reveal two populations of cross-cutting faults with distinct fault-zone materials and a series of southwest-plunging folds. Paleostress axes were reconstructed using the …

Stromatolitic Knobs In Storrs Lake, San Salvador, Bahamas: Insights Into Organomineralization, Alexandre J. Fowler

Master's Theses

Storrs Lake, a hypersaline lake on the east coast of San Salvador Island, Bahamas, contains well-developed microbial mats, some of which have developed calcified structures called microbialites. Many of these microbialites are laminated, and therefore classified as stromatolites. This study focuses on small stromatolitic knobs located in the southern portion of Storrs lake, which are still actively forming, to gain insights into the early stages of stromatolite formation. These knobs appear to be forming as the result of in situ micritic precipitation mediated by both photosynthetic and heterotrophic microbial metabolisms. By comparing these small stromatolitic knobs to larger stromatolitic heads …

Synthesis, Field Emission And Associated Degradation Mechanisms Of Tapered Zno Nanorods, Gregory M. Wrobel Mr.

Master's Theses

Equation 1..... 4

Equation 2..... 4

Equation 3..... 6

Equation 4..... 7

Equation 5..... 9

Equation 6..... 10

Equation 7..... 11

Equation 8..... 12

Equation 9..... 14

Equation 10..... 40

Equation 11..... 51

Synthesis, Field Emission and Associated Degradation Mechanisms of Tapered ZnO Nanorods

Gregory Michael Wrobel, M.S.

University of Connecticut, 2011

Modern development of field emitter arrays (FEA) has been made possible, partly thanks to the synthesis and development of one-dimensional (1D) nanostructures. High aspect ratio 1D nanostructures effectively amplify the electric field at the emitter tips, allowing electrons to be extracted at relatively low electric field. An inexpensive …

"Buy Local" Consumer Behavior And Wood Products: A Case Study, Charlotte C. Rand

Master's Theses

Consumers in the United States are increasingly interested in buying locally grown/produced (LG/P) agricultural products (Connor et al. 2009). In comparison, consumer interest in buying local wood products is not evident. In the same way that the LG/P agriculture phenomenon has helped preserve farmland and foster awareness of where food originates, expanding local production of forest products may also create similar benefits for forestland both locally and globally. However, studies examining the “Buy Local” phenomenon and its potential to inform the local production of wood products are not apparent in the literature.

This study examined consumer attitudes and beliefs that …

Amibe: An Imperative Programming Language With First Class Continuations, Yuting Wang

Master's Theses

A continuation represents the future of an execution. It is often used as an intermediate representation(IR) to compile functional programming languages, make control flow explicit and full beta-reduction(function inlining) possible. Continuations are also a language feature that gives user the ability to completely control the execution control flow(first class continuation). Efficient implementation of first class continuation is important for languages that need non-determinism and backtracking(e.g., COMET). We present a prototype imperative programming language with first class continuation -- AMIBE. AMIBE uses the LLVM compiler infrastructure which is attractive for its optimizing tools and overall modern organization. However, LLVM does not …

Development Of An Approach To Evaluate Fractured Crystalline Bedrock Water Resource Supply And Sustainability, Helen E. Spera

Master's Theses

Groundwater derived from fractured crystalline bedrock is an important resource in Connecticut. Despite its importance we know very little about this resource. This study was conducted at the Plant Science and Landscape Architecture Research and Education Facility, University of Connecticut, Storrs, CT. The objectives of this study were: to improve the characterization of the hydrogeology of the facility; to develop a method to determine the amount of recharge to the bedrock from the overburden during pumping and non-pumping periods; and to develop an approach that can be used in evaluating the sustainability and zone of contribution of bedrock pumping wells. …

Investigation Of The Effect Of Xanthophyll Composition On Energy Transfer And Quenching In Light-Harvesting Complexes From The Diatom, Phaeodactylum Tricornutum, Jose L. Robinson Duggon

Master's Theses

No abstract provided.

Model Based Assessment Of Potential Impacts Of Climate Change On The Flow Of The Main Headwaters Of The Nile River: Equatorial Lakes Region And Blue Nile Basins, Fisseha G. Berhane

Master's Theses

Berhane Fisseha. Model based assessment of potential impacts of climate change on the flow of the main headwaters of the Nile River: Equatorial Lakes Region and Blue Nile basins (Under the direction of Dr. Richard Anyah).

Spatially and temporally detailed assessment of the hydrologic processes of the main sources of the Nile River headwaters (Blue Nile basin and Equatorial Lakes Region) is vital for basin-wide scale management to cope with the pressing water problems due to burgeoning populations, a growing demand for electricity, irrigation for food production and possible climate change.

The main objectives of this study were to use …

Animation And Visualization Of 3d Underwater Sensor Networks, Matthew T. Tran

Master's Theses

Simulation and visualization are critical for the development of new systems and protocols in the area of computer networking. As real-world field testing is expensive and time-consuming, simulations are often preferred as they can be performed repeatedly and inexpensively while still reflecting the outcome of field tests to an extent. Visualizations of the simulation and field test results often follow to provide researchers with a vivid animation of the events, allowing for a much more intuitive understanding of the system than tediously reading through trace files. While there are currently a multitude of simulators and animators for land-based networks, few …

Mechanistic Study Of The Small Molecule Inhibitor Dx-52-1, Junru Cui

Master's Theses

Cell migration is a basic biological process that is fundamental to several normal and disease processes such as embryonic development, tissue repair, immune function, angiogenesis and cancer cell invasion and metastasis. Small organic molecules inhibiting cell migration can be used as both research probes and therapeutic agents. DX-52-1, a semisynthetic derivative of the natural product quinocarmycin (also known as quinocarcin), inhibits the migration of Madin-Darby canine kidney epithelial cells with nanomolar concentration. We have identified galectin-3, a multifunctional protein whose best-known function is its sugar binding ability, as a secondary target of DX-52-1 with functions in cell motility. In addition, …

Towards The Synthesis Of Alpha-Aminogalactosylceramides, Shaun C. Christian

Master's Theses

No abstract provided.

Salt Contamination Of Ground And Surface Water In Connecticut: A Compilation And Synthesis Of Historic Data And Local Scale Testing, James P. Cassanelli

Master's Theses

No abstract provided.

Implementation Of The Clas12 Htcc Into Gemc, Nathan A. Harrison

Master's Theses

No abstract provided.