Physical Sciences and Mathematics Commons^™

Synthesis Of Disubstituted Amino Acids And Peptide Inhibitors Of Amyloid Beta Aggregation, Gregory Todd Mccandless

LSU Master's Theses

The aggregation process of amyloid beta from monomeric peptide to oligomers and fibrils is believed to be connected with the neurological disorder Alzheimer’s disease. The focus of this research is the synthesis of alpha, alpha-disubstituted amino acids and peptide inhibitors of amyloid beta aggregation. The inhibitors are designed to interrupt (or alter) this process by binding to amyloid beta’s central hydrophobic core region (residues 17-20, Leucine-Valine- Phenylalanine-Phenylalanine). Target specificity is achieved via self recognition by basing the inhibitors on the sequence in this region. The inclusion of disubstituted amino acids in the sequence of the inhibitors will provide a blocking …