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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
On The Development Of Analytical Methodologies To Interrogate The Lipid Dynamics And Phase Transition Resulting From The Reduction Of Stimuli-Responsive Vesicles, James Edward Winter
On The Development Of Analytical Methodologies To Interrogate The Lipid Dynamics And Phase Transition Resulting From The Reduction Of Stimuli-Responsive Vesicles, James Edward Winter
LSU Doctoral Dissertations
The potential is great for liposome drug delivery systems that provide specific contents release at diseased tissue sites upon activation by upregulated enzymes; however, this potential will only come to fruition with mechanistic knowledge of the contents release process. NAD(P)H:quinone oxidoreductase type 1 (NQO1) is a target for reductively-responsive liposomes, as it is an enzyme upregulated in numerous cancer tissues and is capable of reducing quinone propionic acid (QPA) trigger groups to hydroquinones that self-cleave from dioleolylphosphatidylethanolamine (DOPE) liposome surfaces, thereby initiating contents release. This research targets the development of analytical methodologies to observe and characterize the dynamics and resulting …
Studies Of Core-Shell Nanogumbos And Liposomal Ionogels, Ashleigh Renee' Wright
Studies Of Core-Shell Nanogumbos And Liposomal Ionogels, Ashleigh Renee' Wright
LSU Doctoral Dissertations
The work presented in this dissertation is a description of novel core-shell nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS) and the synthesis and characterizations of novel liposomal ionogels (LIGs). These GUMBOS are an extension of ionic liquids (ILs) which are organic salts with melting points between 25 °C and 100 °C. Ionic liquids have high thermal stability, low vapor pressure, and tunable physiochemical and functional properties. All of the properties of ILs are controlled by the chosen cation and anion pair. Similarly to ILs, GUMBOS possess the same qualities; however, they have melting points …
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier
LSU Doctoral Dissertations
Over the last few decades, liposomes have generated a lot of interest as drug delivery vehicles to address the need for providing both increased therapeutic efficacy and decreased systemic exposure, simultaneously. The challenge of increasing drug accumulation at diseased sites, without compromising the integrity and stability of the liposomal carrier during circulation, has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes destabilization of the liposome upon exposure …
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
LSU Doctoral Dissertations
For decades, there has been a lot of focus on the development of new carriers for drug delivery applications. From all of the carriers, stimuli-responsive liposomes have been studied extensively, but only a handful have been enzyme-responsive liposomes. Therefore, the field of endogenous proteins as activators of liposomes is a fertile field worthy of exploration. The research described in this dissertation involves how structural changes on the quinone moiety altered their electronic properties, as well as their behavior toward the human enzyme NAD(P)H:quinone oxidoreductase type-1 (hNQO1, over expressed in certain tumor tissues), thus yielding a series of triggerable quinones to …
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
LSU Doctoral Dissertations
Liposomes have had a long and fruitful application of drug delivery devices in the treatment of select tumors and cancer types. Third-generation liposomes possess endogenous triggering methods that hold the ability for site-specific unloading of liposomal contents, thus providing necessary temporal and spatial control over contents release that can be tuned to match the drug efficacy for decreased side effects during treatment. Of these new endogenous triggers, redox-active liposomes that can be triggered to unload contents via two-electron reduction by enzymes or chemical means have demonstrated promise for the encapsulation and delivery of cargo. The research project undertaken involved the …
Self-Assembly And Its Inhibition In Bolaform Amphiphilic Dendrimers, Jirun Sun
Self-Assembly And Its Inhibition In Bolaform Amphiphilic Dendrimers, Jirun Sun
LSU Doctoral Dissertations
Self-assembly is scientifically interesting, technologically important, and sometimes life-threatening. A striking example: Alzheimer’s disease is caused by the self-assembly of the â-amyloid fragment of amyloid precursor protein. Such natural amphiphiles normally are very expensive and complicated to isolate. Synthetic mimics that are much cheaper and easier to prepare can facilitate the development of efficient characterization methods, even as they suggest new materials science applications. Two-directional arborols are synthetic bolaform amphiphilic dendrimers. They dissolve in hot water and form reversible gels at room temperature. Bundles of fibrils, which are made by self-assembly of arborols, are found in the gels. The properties …