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Structure-Function Relationships Affecting The Sensing Mechanism Of Monolayer-Protected Cluster Doped Xerogel Amperometric Glucose Biosensors, Luke T. Dipasquale
Structure-Function Relationships Affecting The Sensing Mechanism Of Monolayer-Protected Cluster Doped Xerogel Amperometric Glucose Biosensors, Luke T. Dipasquale
Honors Theses
The research conducted in the Leopold Bioanalytical and Nanomaterials Analytical Chemistry Lab prior to the summer of 2013 focused on the synthesis of a functional biosensor equipped with a nanoparticle network embedded in a xerogel film for the detection of glucose. Xerogel-based films featuring embedded glucose oxidase enzyme and doped with alkanethiolate-protected gold NPs, known as monolayer protected clusters (MPCs), exhibit significantly enhanced performance compared to analogous systems without NPs including higher sensitivity, faster response time, and extended linear/dynamic ranges.
The following presented research is a systematic study of the structure-function relationships critical to understanding the sensing mechanism of the …