Physical Sciences and Mathematics Commons^™

Predicting Flavonoid Ugt Regioselectivity With Graphical Residue Models And Machine Learning., Arthur Rhydon Jackson

Electronic Theses and Dissertations

Machine learning is applied to a challenging and biologically significant protein classification problem: the prediction of flavonoid UGT acceptor regioselectivity from primary protein sequence. Novel indices characterizing graphical models of protein residues are introduced. The indices are compared with existing amino acid indices and found to cluster residues appropriately. A variety of models employing the indices are then investigated by examining their performance when analyzed using nearest neighbor, support vector machine, and Bayesian neural network classifiers. Improvements over nearest neighbor classifications relying on standard alignment similarity scores are reported.

A Variation Of The Carleman Embedding Method For Second Order Systems., Charles Nunya Dzacka

Electronic Theses and Dissertations

The Carleman Embedding is a method that allows us to embed a finite dimensional system of nonlinear differential equations into a system of infinite dimensional linear differential equations. This technique works well when dealing with first-order nonlinear differential equations. However, for higher order nonlinear ordinary differential equations, it is difficult to use the Carleman Embedding method. This project will examine the Carleman Embedding and a variation of the method which is very convenient in applying to second order systems of nonlinear equations.

Vitis Seeds (Vitaceae) From The Late Neogene Gray Fossil Site, Northeastern Tennessee, Usa., Fade Gong

Electronic Theses and Dissertations

This study focuses on the morphometric and systematic studies of fossil vitaceous seeds recently recovered from the Gray Fossil Site (7-4.5 Ma, latest Miocene-earliest Pliocene) northeastern Tennessee. Morphologically, all fossil seeds correspond to the extant subgenus Vitis (genus Vitis) of the Vitaceae based on the smooth dorsal surface with a centrally positioned chalaza connected with a conspicuous chalaza-apex groove and short linear ventral infolds that are slightly diverged apically. A multivariate analysis based on 11 measured characters from 76 complete seeds identified three types of seeds, each representing a distinct morphotaxon. Based on comparison with modern and fossil vitaceous …

Determination Of The Activation Parameters Of Reaction Between [Fe(Cn6]-4 And K[Co(Hedta)No2]., Sammy Eni Eni

Electronic Theses and Dissertations

The kinetics of the oxidation of [Fe(CN)₆]^-4 by K[Co(HEDTA)NO₂] was studied in order to get the mechanism and the activation parameters of the reaction. Using a freshly-made Na₃PO₄ solution as the reaction medium with a pH of 6.00 the ionic strength was maintained at 0.10 M and the buffer molarity was 0.001 M.

The rate constant (k_obs) of the reaction between [Fe(CN)₆]^-4 and K[Co(HEDTA)NO₂] was determined at temperatures of 25.0°C, 27.5°C, 30.0°C, 35.0°, and 40.0°C. We explored this reaction by monitoring the evolution of ferricyanide, …

Studies Of Titanium Dioxide Nanoparticles And Surfactants Effects, Singly And In Combinations, On Luminescence Intensity Of Some Aromatic Compounds., Charles Anim Odame-Ankrah

Electronic Theses and Dissertations

Luminescence techniques are sensitive, selective, and widely used in analysis. Luminescence intensity is attenuated by quenchers. This research has focused on the use of surfactants such as CTAB, SDS, and TX-100 singly or together with TiO₂ nanoparticles to evaluate their individual and combined effects on some fluorescent aromatic compounds such as pyrene, fluoranthene, anthracene, phenanthrene, and carbazole. Rutile phase TiO₂ was synthesized using the low temperature sol-gel method. Carbazole and phenanthrene were severely quenched by all surfactants singly or in combination with TiO₂. Anthracene and fluoranthene showed some enhancement in their luminescence intensity. The most dramatic …

Studies Of Capsaicinoids Contents Of Locally Grown And Commercial Chilies Using Reversed-Phase High Performance Liquid Chromatography., John Kailemia Muchena

Electronic Theses and Dissertations

Capsaicinoids are a class of compounds responsible for the "heat" of hot peppers. Capsaicin and dihydrocapsaicin have the highest burning effect. The aim of this work is to separate and quantify the two major capsaicinoids in fruits harvested at different stages of development and at different seasons. Simple and rapid HPLC method involves 73:27% methanol water mobile phase with C₁₈ stationary phase and UV-Vis detector set at 210 nm. The method showed good reproducibility with 1.74% - 4.72% relative standard deviations, a linear response within 0.65–45.5 and 0.25-17.5 μg/mL for capsaicin and dihydrocapsaicin, respectively. The method achieved average recovery …

Qualitative Models Of Neural Activity And The Carleman Embedding Technique., Azamed Yehuala Gezahagne

Electronic Theses and Dissertations

The two variable Fitzhugh Nagumo model behaves qualitatively like the four variable Hodgkin-Huxley space clamped system and is more mathematically tractable than the Hodgkin Huxley model, thus allowing the action potential and other properties of the Hodgkin Huxley system to be more readily be visualized. In this thesis, it is shown that the Carleman Embedding Technique can be applied to both the Fitzhugh Nagumo model and to Van der Pol's model of nonlinear oscillation, which are both finite nonlinear systems of differential equations. The Carleman technique can thus be used to obtain approximate solutions of the Fitzhugh Nagumo model and …

A Phylogenetic Analysis Of Species Relationships In Hemlocks, The Genus Tsuga (Pinaceae)., Jordan David Baker

Electronic Theses and Dissertations

The genus Tsuga is comprised of eight extant species found in North America and East Asia and four species represented by fossils from Europe and Japan. This study presents the first phylogenetic analysis based on structural, biochemical, and molecular sequence data. Characters obtained from published and unpublished literature were combined with new morphological characters from seeds, seedlings, and leaf cuticle material. Results from parsimony analyses of these characters differed from the published molecular based phylogeny. The non-molecular based phylogeny resolves two separate clades, a North American and an Asian, but did not group the western North American species, as in …

Novel Strategy For The Synthesis Of Allenes., Mark-Henry Mbahmi Kamga

Electronic Theses and Dissertations

Allenes are very important chemical reagents in organic synthesis. Due to their high reactivity, they have been extensively used to carry out a variety of unique and effective chemical transformations including but not limited to ionic and free radical additions and transition metal catalyzed cyclizations. As the chemistry of this group of compounds is explored further and their applications expanded there is a need to develop alternative and cost effective methods for their synthesis. Our approach involves the synthesis of allenes from oxa-bicyclo-alkan-2-ones by methyllithium induced Eschenmoser fragmentation of the bicyclotosylhydrazone derivatives.

Computational Investigation Of Spin Traps Using Hybrid Solvation Models., Sai Sriharsha Manoj Konda

Electronic Theses and Dissertations

The cyclic nitrone 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), and the lesser known linear phenyl-N-tert-butylnitrone (PBN) and its phosphorylated analogues have been used as spin traps for the investigation of free radicals in biological systems. Theoretical work on these molecules suggests that there are important differences in their properties between biological systems and isolated molecules in the gas phase, most likely resulting from intra and intermolecular hydrogen bonding. Most dielectric solvation models such as the polarized continuum model and COSMO are incapable of direct determination of solvent-spin trap chemical interactions. To examine this, hybrid models incorporating COSMO for long range effects and discrete solvent …

Studies Of The Preparations And Use Of Sol-Gel For Enzyme Immobilization And Analytical Applications., Suzana Hamdan

Electronic Theses and Dissertations

Much attention has been paid to immobilization of enzymes to improve enzyme stability and permit its reuse. Glucose oxidase entrapment in different kinds of silica sol-gel matrices was investigated. The enzyme showed stable activity for 11 uses in the sol-gel with tetramethyl orthosilicate (TMOS) as precursor, and at least 7 uses in the sol-gel induced electrochemically with tetraethyl orthosilicate (TEOS) as precursor. The sol-gel made with TEOS as precursor and HCl as catalyst showed stability in enzyme activity for 11 uses but the activity decreases on the same sol-gel when modified with silica nanoparticles. Factors such as optimal incubation time …

The Last Of The Mixed Triple Systems., Ernest Jum

Electronic Theses and Dissertations

In this thesis, we consider the decomposition of the complete mixed graph on v vertices denoted M_v, into every possible mixed graph on three vertices which has (like M_v) twice as many arcs as edges. Direct constructions are given in most cases. Decompositions of theλ-fold complete mixed graph λM_v, are also studied.

Independent Domination In Complementary Prisms., Joel Agustin Gongora

Electronic Theses and Dissertations

Let G be a graph and G̅ be the complement of G. The complementary prism GG̅ of G is the graph formed from the disjoint union of G and G̅ by adding the edges of a perfect matching between the corresponding vertices of G and G̅. For example, if G is a 5-cycle, then GG̅ is the Petersen graph. In this paper we investigate independent domination in complementary prisms.

Salamanders Of The Mio-Pliocene Gray Fossil Site, Washington County, Tennessee., Grant Stanley Boardman

Electronic Theses and Dissertations

Screening efforts at the Gray Fossil Site, Washington County, Tennessee, have yielded a unique and diverse salamander fauna for the southern Appalachian Mio-Pliocene; including at least five taxa from three modern families (Ambystomatidae, Plethodontidae, and Salamandridae) supporting the woodland-pond interpretation of the site. All specimens represent the earliest record of their respective families in the Appalachian Mountains; with the Notophthalmus sp. vertebrae being the only Mio-Pliocene skeletal fossil known for the family Salamandridae in North America. Three types of plethodontid salamander are present, with one type representing the earliest known desmognathine. The desmognathine fossils lend credence to the 'Appalachian' origin …

Decompositions Of Mixed Graphs With Partial Orientations Of The P4., Adam M. Meadows

Electronic Theses and Dissertations

A decomposition D of a graph H by a graph G is a partition of the edge set of H such that the subgraph induced by the edges in each part of the partition is isomorphic to G. A mixed graph on V vertices is an ordered pair (V,C), where V is a set of vertices, |V| = v, and C is a set of ordered and unordered pairs, denoted (x, y) and [x, y] respectively, of elements of V [8]. An ordered pair (x …

Locating-Domination In Complementary Prisms., Kristin Renee Stone Holmes

Electronic Theses and Dissertations

Let G = (V (G), E(G)) be a graph and G̅ be the complement of G. The complementary prism of G, denoted GG̅, is the graph formed from the disjoint union of G and G̅ by adding the edges of a perfect matching between the corresponding vertices of G and G̅. A set D ⊆ V (G) is a locating-dominating set of G if for every u ∈ V (G)D, its neighborhood N(u)⋂D is nonempty and distinct from N( …

Cyclic, F-Cyclic, And Bicyclic Decompositions Of The Complete Graph Into The 4-Cycle With A Pendant Edge., Daniel Shelton Cantrell

Electronic Theses and Dissertations

In this paper, we consider decompositions of the complete graph on v vertices into 4-cycles with a pendant edge. In part, we will consider decompositions which admit automorphisms consisting of:

(1) a single cycle of length v,

(2) f fixed points and a cycle of length v − f, or

(3) two disjoint cycles.

The purpose of this thesis is to give necessary and sufficient conditions for the existence of cyclic, f-cyclic, and bicyclic Q-decompositions of K_v.

Development Of A Reservoir Embayment Characterization Process To Prioritize Water Quality Improvement., Terry Shannon O'Quinn

Electronic Theses and Dissertations

To simplify water quality improvement in reservoirs, it has been suggested that efforts should be focused on smaller and more manageable units such as reservoir embayment areas. Embayments are prime locations to locate marinas, parks, beaches, and residential homes. Current data and information on reservoir embayments in Tennessee was assembled into a GIS-based database. Embayments of 11 main reservoirs were mapped and digitized in ArcGIS. Initial characterization criteria include watershed size, embayment area-watershed ratio, maximum residence time, and stream influence on embayments. The characterization process was then applied to the mapped reservoir embayments in Tennessee to identify and prioritize embayments …