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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Atmospheric Organic Matter In Clouds: Exact Masses And Molecular Formula Identification Using Ultrahigh-Resolution Ft-Icr Mass Spectrometry, Y. Zhao, A. G. Hallar, Lynn Mazzoleni
Atmospheric Organic Matter In Clouds: Exact Masses And Molecular Formula Identification Using Ultrahigh-Resolution Ft-Icr Mass Spectrometry, Y. Zhao, A. G. Hallar, Lynn Mazzoleni
Department of Chemistry Publications
Clouds alter the composition of atmospheric aerosol by acting as a medium for interactions between gas- and particulate-phase substances. To determine the cloud water atmospheric organic matter (AOM) composition and study the cloud processing of aerosols, two samples of supercooled clouds were collected at the Storm Peak Laboratory near Steamboat Springs, Colorado (3220 m a.s.l.). Approximately 3000 molecular formulas were assigned to ultrahigh-resolution mass spectra of the samples after using a reversed-phase extraction procedure to isolate the AOM components from the cloud water. Nitrogen-containing compounds (CHNO compounds), sulfur-containing compounds (CHOS and CHNOS compounds) and other oxygen-containing compounds (CHO compounds) with …
Inhibition Of Fast Axonal Transport By Pathogenic Sod1 Involves Activation Of P38 Map Kinase, Gerardo Morfini, Daryl Bosco, Hannah Brown, Rodolfo Gatto, Agnieszka Kaminska, Yuyu Song, Ashutosh Tiwari, Et. Al.
Inhibition Of Fast Axonal Transport By Pathogenic Sod1 Involves Activation Of P38 Map Kinase, Gerardo Morfini, Daryl Bosco, Hannah Brown, Rodolfo Gatto, Agnieszka Kaminska, Yuyu Song, Ashutosh Tiwari, Et. Al.
Department of Chemistry Publications
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FALS include abnormal kinase activation, aberrant neurofilament phosphorylation, and fast axonal transport (FAT) deficits, but functional relationships among these pathogenic events were unclear. Experiments in isolated squid axoplasm reveal that FALS-related SOD1 mutant polypeptides inhibit FAT through a mechanism involving a p38 mitogen activated protein kinase pathway. Mutant SOD1 activated neuronal p38 in mouse spinal cord, neuroblastoma cells and squid axoplasm. Active p38 …