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Full-Text Articles in Physical Sciences and Mathematics
Dehydrotropylium-Co2(Co)6 Ion. Generation, Reactivity And Evaluation Of Cation Stability, Sheida Amiralaei, James Gauld, James R. Green
Dehydrotropylium-Co2(Co)6 Ion. Generation, Reactivity And Evaluation Of Cation Stability, Sheida Amiralaei, James Gauld, James R. Green
Chemistry and Biochemistry Publications
The dehydrotropylium–Co2(CO)6 ion was generated by the action of HBF4 or BF3⋅OEt2 on the corresponding cycloheptadienynol complex, which in turn has been prepared in four steps from a known diacetoxycycloheptenyne complex. The reaction of the cycloheptadienynol complex via the dehydrotropylium–Co2(CO)6 ion with several nucleophiles results in substitution reactions with reactive nucleophiles (N>1) under normal conditions, and a radical dimerisation reaction in the presence of less reactive nucleophiles. Competitive reactions of the cycloheptadienynol complex with an acyclic trienynol complex show no preference for generation of the dehydrotropylium–Co2 …
Synthesis Of ‘Spacer’-Naproxen [2-(6-Methoxybiphenylen-2-Yl)Propanoic Acid] And -Isonaproxen [2-(7-Methoxybiphenylen-2-Yl)Propanoic Acid], Juan A. González Gómez, James R. Green, Peter C. Vollhardt
Synthesis Of ‘Spacer’-Naproxen [2-(6-Methoxybiphenylen-2-Yl)Propanoic Acid] And -Isonaproxen [2-(7-Methoxybiphenylen-2-Yl)Propanoic Acid], Juan A. González Gómez, James R. Green, Peter C. Vollhardt
Chemistry and Biochemistry Publications
The CpCo(CO)2-catalyzed cocyclization of 1,2-diethynyl- 4-methoxybenzene with alkynes can be applied to the synthesis of ‘spacer’-naproxen [2-(6-methoxybiphenylen-2-yl)propanoic acid] and its 7-methoxy isomer, ‘spacer’-isonaproxen. While unsymmetrical alkynes are incorporated without regioselectivity, the methoxy group in 6-methoxy-2,3-bis(trimethylsilyl)biphenylene directs electrophiles to C-3, thus allowing for regiochemical differentiation between the 2- and 3-positions.
Tandem 4+3 Cycloaddition/Nucleophilic Trapping Reactions Of Butyne-1,4-Diether Dicobalt Hexacarbonyl Complexes, Yafan Lu, James R. Green
Tandem 4+3 Cycloaddition/Nucleophilic Trapping Reactions Of Butyne-1,4-Diether Dicobalt Hexacarbonyl Complexes, Yafan Lu, James R. Green
Chemistry and Biochemistry Publications
Butyne-1,4-diether hexacarbonyldicobalt complexes 1 undergo Lewis acid mediated 4+3 cycloadditions with allylsilanes, incorporating halide from the Lewis acid to give halocycloheptynes 3, 6, 7. A phenyl group may be incorporated in place of the halogen (to give 8) by use of benzene as solvent and with B(C6F5)(3) as the Lewis acid; chlorobenzene and toluene also participate in the process.