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Full-Text Articles in Physical Sciences and Mathematics
Transesterification Of Poly(Ethyl Glyoxylate): A Route To Structurally Diverse Polyglyoxylates, Rebecca E. Yardley, Amir Rabiee Kenaree, Xiaoli Liang, Elizabeth R. Gillies
Transesterification Of Poly(Ethyl Glyoxylate): A Route To Structurally Diverse Polyglyoxylates, Rebecca E. Yardley, Amir Rabiee Kenaree, Xiaoli Liang, Elizabeth R. Gillies
Chemistry Publications
Polyglyoxylates are a class of self-immolative polymers that depolymerize in solution and the solid state. The glyoxylic acid degradation product is a metabolite in the glyoxylate cycle and can also be processed in the liver in humans, making polyglyoxylates attractive for applications in the environment and in medicine. Although expanding the scope of available polyglyoxylates would enable new properties and applications, highly pure glyoxylate monomers are required for polymerization, and this level of purity is difficult to achieve for many potential monomers. To address this challenge, we report here the 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-catalyzed post-polymerization transesterification of poly(ethyl glyoxylate) (PEtG) as a …
Ytterbium Triflate Catalyzed Synthesis Of Alkoxy-Substituted Donor-Acceptor Cyclobutanes And Their Formal [4 + 2] Cycloaddition With Imines: Stereoselective Synthesis Of Piperidines., Mahmoud M Abd Rabo Moustafa, Brian L Pagenkopf
Ytterbium Triflate Catalyzed Synthesis Of Alkoxy-Substituted Donor-Acceptor Cyclobutanes And Their Formal [4 + 2] Cycloaddition With Imines: Stereoselective Synthesis Of Piperidines., Mahmoud M Abd Rabo Moustafa, Brian L Pagenkopf
Chemistry Publications
A new synthesis of 2-alkoxy-1,1-cyclobutane diesters and their first use in dipolar cycloadditions is reported. Both the formation of the donor-acceptor cyclobutanes and their subsequent annulation with in situ formed imines are catalyzed by Yb(OTf)(3). Cyclobutanes with carbon donor groups give piperidines with high trans stereoselectivity.
Formal [4 + 2] Cycloaddition Of Alkoxy-Substituted Donor-Acceptor Cyclobutanes And Aldehydes Catalyzed By Yb(Otf)3., Mahmoud M Abd Rabo Moustafa, Andrew C Stevens, Ben P Machin, Brian L Pagenkopf
Formal [4 + 2] Cycloaddition Of Alkoxy-Substituted Donor-Acceptor Cyclobutanes And Aldehydes Catalyzed By Yb(Otf)3., Mahmoud M Abd Rabo Moustafa, Andrew C Stevens, Ben P Machin, Brian L Pagenkopf
Chemistry Publications
The cycloaddition between 2-alkoxy-1,1-cyclobutane diesters and aromatic, heteroaromatic, or aliphatic aldehydes under Yb(OTf)(3) catalysis generates tetrahydropyrans in high yields with exclusive cis-stereochemistry.
C-2/C-3 Annulation And C-2 Alkylation Of Indoles With 2-Alkoxycyclopropanoate Esters., Barbora Bajtos, Ming Yu, Hongda Zhao, Brian L Pagenkopf
C-2/C-3 Annulation And C-2 Alkylation Of Indoles With 2-Alkoxycyclopropanoate Esters., Barbora Bajtos, Ming Yu, Hongda Zhao, Brian L Pagenkopf
Chemistry Publications
The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole substrates, and an intervening C-3 to C-2-migration process arose that gives synthetically useful C-2 alkylation indole products.