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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Thermoresponsive Self-Immolative Polyglyoxylamides., Amir Rabiee Kenaree, Quinton E. A. Sirianni, Kyle Classen, Elizabeth R. Gillies
Thermoresponsive Self-Immolative Polyglyoxylamides., Amir Rabiee Kenaree, Quinton E. A. Sirianni, Kyle Classen, Elizabeth R. Gillies
Chemistry Publications
Thermoresponsive polymers with lower critical solution temperatures (LCSTs) are of significant interest for a wide range of applications from sensors to drug delivery vehicles. However, the most widely investigated LCST polymers have nondegradable backbones, limiting their applications
Analysis Of Temperature-Dependent H/D Exchange Mass Spectrometry Experiments., Nastaran N Tajoddin, Lars Konermann
Analysis Of Temperature-Dependent H/D Exchange Mass Spectrometry Experiments., Nastaran N Tajoddin, Lars Konermann
Chemistry Publications
H/D exchange (HDX) mass spectrometry (MS) is a widely used technique for interrogating protein structure and dynamics. Backbone HDX is mediated by opening/closing (unfolding/refolding) fluctuations. In traditional HDX-MS, proteins are incubated in D2O as a function of time at constant temperature (T). There is an urgent need to complement this traditional approach with experiments that probe proteins in a T-dependent fashion, e.g., for assessing the stability of therapeutic antibodies. A key problem with such studies is the absence of strategies for interpreting HDX-MS data in the context of T-dependent protein dynamics. Specifically, it has …