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Evaluation Of The Macrocyclic Antibiotic Avoparcin As A New Chiral Selector For Hplc, K. Helen Ekborg-Ott, John P. Kullman, Xiande Wang, Kyung Gahm, Lingfeng He, Daniel W. Armstrong
Evaluation Of The Macrocyclic Antibiotic Avoparcin As A New Chiral Selector For Hplc, K. Helen Ekborg-Ott, John P. Kullman, Xiande Wang, Kyung Gahm, Lingfeng He, Daniel W. Armstrong
Chemistry Faculty Research & Creative Works
Avoparcin is a macrocyclic glycopeptide antibiotic structurally related to vancomycin, teicoplanin, and ristocetin A. When attached to 5-μm spherical silica gel, the avoparcin proved to be an effective chiral stationary phase (CSP) that could be used in the reversed-phase, normal- phase, and polar-organic modes. The avoparcin CSP was complimentary to the other macrocyclic glycopeptide CSPs in that it could resolve some racemates that the others could not, and vice versa. Some important compounds resolved on the avoparcin CSP include verapamil, thyroxine, mephenytoin, and 2- imidazolidone-4-carboxylic acid. The use of this CSP and the optimization of separations on it are discussed. …
The Evolution Of Chiral Stationary Phases For Liquid Chromatography, Daniel W. Armstrong
The Evolution Of Chiral Stationary Phases For Liquid Chromatography, Daniel W. Armstrong
Chemistry Faculty Research & Creative Works
The development of effective chiral stationary phases (CSPs) and separation strategies for the liquid chromatographic (LC) resolution of enantiomers has been beneficial to many scientific disciplines. Over the last decade the number and type of CSPs has expanded tremendously. Not only have new classes of chiral selectors been introduced, but also many of the first CSPs have been changed and/or improved. The second or third generation of a CSP often can be different from the original. This can be confusing and intimidating to someone just entering the area of LC enantiomeric separations. Fortunately, all CSPs can be categorized in one …