Physical Sciences and Mathematics Commons^™

A Phase I And Pharmacologic Study Of Weekly Gemcitabine In Combination With Infusional 5-Fluorodeoxyuridine And Oral Calcium Leucovorin, Jean L. Grem, Mary G. Quinn, Bruce Keith, Brian P. Monahan, J. Michael Hamilton, Yan Xu, Nancy Harold, Dat Nguyen, Chris H. Takimoto, Anthony Rowedder, Janet Pang, Geraldine Morrison, Alice Chen

Chemistry Faculty Publications

Purpose: Since preclinical studies have shown more than additive cytotoxicity and DNA damage with the combination of gemcitabine and 5-fluoro-2′-deoxyuridine (FUDR), we studied this combination in a phase I trial. Methods: Gemcitabine alone was given in cycle 1 as a 24-h, 2-h or 1-h i.v. infusion weekly for 3 of 4 weeks; if tolerated, a 24-h i.v. infusion of FUDR was added with oral leucovorin. The cycle was aborted for grade 3 thrombocytopenia, grade 4 neutropenia, and grade 2 or worse nonhematologic toxicity. Results: During cycle 1, six of eight patients who received 150 or 100 mg/m2 over 24 h …