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Feasibility Of Cyclodextrin-Potassium Ion Assemblies Synthesis And Its Application In Loading Bio-Active Molecules, Yomkippur Perez, Gilbert U. Yu
Feasibility Of Cyclodextrin-Potassium Ion Assemblies Synthesis And Its Application In Loading Bio-Active Molecules, Yomkippur Perez, Gilbert U. Yu
Chemistry Faculty Publications
In the study, colorless cubic crystals of “green” cyclodextrin (CD)-based assemblies were synthesized and their potential to load bio-active molecules such as drugs and, separately, enzymes were investigated. Busulfan (Bu), an anti-cancer drug widely used to treat chronic myelogenous leukemia (CML), was used as a test drug while trypsin and lipase were used as model enzymes. These porous CD-K+ ion assemblies were prepared by dissolving alkali metal salts and γ-CD in water followed by vapor diffusion in varying solvents for several days. Crystals were activated via dichloromethane dispersion and in vacuo drying. Slow vapor diffusion with ethanol was found to …
Design Of Novel Anticancer Drugs Utilizing Busulfan For Optimizing Pharmacological Properties And Pattern Recognition Techniques For Elucidation Of Clinical Efficacy, Ronald Bartzatt
Chemistry Faculty Publications
Chronic myelogenous leukemia (CML) is a disorder in which an excessive number of blood stem cells develop into the white blood cell group called granulocytes. The anticancer drug Busulfan is a cell cycle non-specific alkylating agent which is utilized to maintain white blood cell counts below 15000 cells/microliter. The side effects induced by busulfan are significant and affirms the intimation for new drug constructs. Fifteen analogous compounds were generated from the molecular structure of busulfan . These compounds retain the double methanesulfonate functional groups descriptive of this class of alkylating anticancer drugs. However, the carbon chain substituent separating the methanesulfonate …