Physical Sciences and Mathematics Commons^™

The Design Of Flow Injection Manifolds To Give The Best Detection Limits For Methods Involving On-Line Chemical Derivatisation Part 1. Theoretical Basis For High Sensitivity, Julian Tyson

Chemistry Department Faculty Publication Series

The criteria to be considered when designing a flow-injection manifold for the highest sensitivity for a method based on measurement of the peak height corresponding to a derivative formed on-line between the injectate and a reagent. These criteria include the ratio of reagent concentration to determinand concentration at the peak maximum, the concentration of the top standard and the reagent composition. These three parameters can be combined to give a single parameter referred to as the a-value being the ratio of the determinand to reagent dispersion coefficients at the peak maximum for the top standard. It is shown, on the …