Physical Sciences and Mathematics Commons^™

Electrical Stimulation With A Conductive Polymer Promotes Neurite Outgrowth And Synaptogenesis In Primary Cortical Neurons In 3d, Qingsheng Zhang, Stephen T. Beirne, Kewei Shu, Dorna Esrafilzadeh, Xu-Feng Huang, Gordon G. Wallace

Australian Institute for Innovative Materials - Papers

Deficits in neurite outgrowth and synaptogenesis have been recognized as an underlying developmental aetiology of psychosis. Electrical stimulation promotes neuronal induction including neurite outgrowth and branching. However, the effect of electrical stimulation using 3D electrodes on neurite outgrowth and synaptogenesis has not been explored. This study examined the effect of 3D electrical stimulation on 3D primary cortical neuronal cultures. 3D electrical stimulation improved neurite outgrowth in 3D neuronal cultures from both wild-Type and NRG1-knockout (NRG1-KO) mice. The expression of synaptophysin and PSD95 were elevated under 3D electrical stimulation. Interestingly, 3D electrical stimulation also improved neural cell aggregation as well as …