Physical Sciences and Mathematics Commons^™

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …

Lxr Acts As A Differentiator In The Regulation Of Fas And G6pdh Gene Expression Under Insulin Resistant Conditions, Jaafar Hachem

Dissertations

Diabetes is a chronic disease that effects 10 percent of the world’s population and causes more than 1.5 million deaths a year and billions of dollars in associated health care cost. It can lead to very serious complications such as renal failure, liver cirrhosis, heart attack, and vision loss. The most common type of diabetes is type 2 diabetes. Type 2 diabetes arises when blood glucose levels remain chronically high due to insulin resistance. The reason for this elevation is due to the failure of insulin to allow tissues to uptake glucose causing problems in subsequent metabolic pathways. Over the …

Development Of Sensor, Sensory System And Signal Processing Algorithm For Intelligent Sensing Applications, Xingzhe Zhang

Dissertations

Sensors have been receiving significant attention in the last decade and the demand for sensory systems has increased in recent years due to the rapid growth in the field of artificial intelligence (AI). Sensors can improve people’s awareness by providing them with real-time information on the environment and their immediate health conditions. This dissertation presents the fulfilment of three main projects and focuses on the development of a sensor, a sensory system, and a sensor signal recognition system for AI applications by employing printed electronics, analog circuit design, and digital signal processing techniques.

In the first project, a multi-channel stethograph …

Estimation Of Odds Ratio In 2 X 2 Contingency Tables With Small Cell Counts, Guohao Zhu

Dissertations

This study is focusing on properties of estimators of odds ratio or its logarithm in case of 2x2 tables with small counts. The odds ratio represents the odds that an outcome of interest will occur given a particular exposure, compared to the odds of the outcome occurring in the absence of that exposure. Both parameters are often used to quantify the strength of association of two binary variables and are common measurements reported in case-control, cohort, and cross-sectional studies.

Because of their wide applicability, both parameters, odds ratio, and its logarithm, have been intensively studied in the literature. However, most …

"Not In My Town": A Community's Response To Water And Soil Pollution, Karolina Staros

Dissertations

At the core of this dissertation is the acknowledgment that social movements are complex networks of people who face many obstacles in their efforts to achieve social change. One critique of social movements is that their goals and mission are limited to short term ideas and not long-term, systemic transformation. The lack of long term, systemic change can be observed when social movement groups mobilize for the same cause over and over again with what appears to be little progress over a period of time. The exact blueprint for a social movement’s success does not exist, but it is posited …

Understanding Potential Climate Change Impacts On Water Resources Within A Fractured Rock Watershed In Northern Togo, Mahawa-Essa Mabossani Akara

Dissertations

More than 72% of sub-Saharan Africa land surface is comprised of hard rock with fractured rock aquifers supplying water to an estimated 25% of the rural population. Given low porosity and storativity, fractured rock aquifers are particularly vulnerable to stresses such as projected population growth and climate variability. General circulation models of sub-Saharan Africa predict increases in temperature and in occurrences of extreme precipitation trends, such as flooding and drought. Adaptation strategies that promote optimal uses of water resources have emerged, although, most focus exclusively on surface water resources. This project investigates the potential impact of climate change on surface …

Synthesis And Characterization Of Novel Organic Ligands With Their Complexes Of Platinum, Copper And Uranium, Mustafa Adnan Yasin Aldulaimi

Dissertations

Transition metal complexes of symmetrical and asymmetrical Schiff bases have played a significant role in the field of coordination, inorganic, and bioinorganic chemistry as models for biological, analytical, industrial, and pharmaceutical applications. Over recent years a great deal of interest has developed in new transition metal complexes of Schiff base ligand. The preparation of novel organic ligands is the most important step in the development of metal complexes that exhibit unique properties and novel reactivity. To highlight the presentation of this dissertation and to provide more detailed investigations, the dissertation was separated into six chapters according to the sequence of …

Novel Low Temperature Properties Of Filled And Unfilled Single Crystal Irsb3, Matthew Cook

Dissertations

The skutterudite family of materials has garnered a lot of attention in the condensed matter community and it persists to be an important system for exploring the fundamental physics of solids. The initial interest into compounds with this common structure was due to their promising thermoelectric properties giving the possibility of efficient energy harvesting. Since, there has been a huge effort to systematically synthesize new filled skutterudite compounds, as nearly every type of strongly correlated behavior has been found within this family. As the field of topological materials has gained momentum, these materials have also been given a renewed interest …

Characterizing Undergraduate Students’ Proving Processes Around “Stuck Points”, Yaomingxin Lu

Dissertations

Learning to prove mathematical propositions is a cornerstone of mathematics as a discipline (de Villiers, 1990). However, since proving is a different mathematical activity as compared to students’ prior experience, research has also shown that many undergraduate students struggle to learn to prove, including those who major in mathematics (Moore, 1994; Selden, 2012). While the field has generated research that has analyzed the final products of proof (Selden & Selden, 2009) and there are frameworks for analyzing problem-solving processes (e.g., Carlson & Bloom, 2005; Schoenfeld, 1985, 2010), much remains to be known about analyzing undergraduate students’ proving processes. With a …

Dominating Functions In Graphs, Maria Talanda-Fisher

Dissertations

Domination in graphs has become one of the most popular areas of graph the- ory, no doubt due to its many fascinating problems and applications to modern society, as well as the sheer mathematical beauty of the subject. While this area evidently began with the work by the French mathematician Claude Berge in 1958 and the Norwegian-American mathematician Oystein Ore in 1962, domination did not become an active area of research until 1977 with the appearance of the survey paper by Ernest Cockayne and Stephen Hedetniemi. Since then a large number of variations of domination have surfaced and provided numerous …

From Multi-Prime To Subset Labelings Of Graphs, Bethel I. Mcgrew

Dissertations

A graph labeling is an assignment of labels (elements of some set) to the vertices or edges (or both) of a graph G. If only the vertices of G are labeled, then the resulting graph is a vertex-labeled graph. If only the edges are labeled, the resulting graph is an edge-labeled graph. The concept was first introduced in the 19th century when Arthur Cayley established Cayley’s Tree Formula, which proved that there are n^n-2 distinct labeled trees of order n. Since then, it has grown into a popular research area.

In this study, we first review several types …

Dolomite Stoichiometry As A Proxy For Fluid Chemistry, Cameron J. Manche

Dissertations

The origin of massive dolomites is a contentious issue in geology. Because modern dolomite is rare, interpretation of ancient dolomites requires the use of proxy resources, most of which provide ambiguous information. High-temperature dolomite synthesis experiments have shown that dolomite stoichiometry, the degree of cation ordering, and reaction rate are controlled by Mg:Ca, temperature, molarity, and salinity of the formative solution. Thus, it is posited here that dolomite stoichiometry may be a useful proxy for fluid chemistry, as are stable isotope and trace element composition of ancient dolomites. High-frequency sample intervals (cm-scale) from the Cretaceous Upper Glen Rose Formation (Comanche …

On Prediction Of Early Signs Of Alzheimer’S— A Machine Learning Framework, Abdalrahman Alsaedi

Dissertations

Dementia is a collective term used to indicate a loss of memory functions with the presence of at least one additional loss of a major cognitive ability that hinders a person’s previous level of functioning. Studies show that dementia is highly age- associated and that the most common cause of dementia is Alzheimer’s disease. Early recognition of Alzheimer’s disease, before irreversible damage to the brain has already occurred, is paramount to slowing or preventing the disease. Therefore, algorithms for the prediction of early signs of dementia are essential. Machine learning approach has been reported to use several data sources such …

Advancing The Use Of Quality Control Tools For High-Density Data In Modern Manufacturing, Romina Dastoorian

Dissertations

In modern manufacturing, advanced metrology systems are continually being incorporated into quality control (QC) systems to provide high-density (HD) datasets. These datasets can contain millions of measurements that can be used to represent a part’s whole geometry. While integrating HD datasets into QC systems has brought several opportunities to enhance the performance of QC systems, it has resulted in new challenges in this area as well. While significant amounts of research have been performed in this area, the QC research community still strives to tackle these challenges. This study identifies key challenges regarding incorporating HD datasets into QC systems. Specifically, …

Institutional Changes In Western Michigan University For Incorporation Of Education For Sustainability, Saman Khan

Dissertations

Higher Education institutions (HEIs) have the potential to be significant contributors in the pursuit of a sustainable world through the incorporation of Education for Sustainability (EFS). However, HEIs are entrenched with structures and values that are often resistant to change. The literature reveals that instructors’ beliefs and institutional contexts are the two main factors that impact the implementation of institutional change for sustainability education. Western Michigan University (WMU) has created new required curriculum “WMU Essential Studies” (WES) for undergraduate students and they have targeted sustainability as an essential learning outcome, by integrating and applying it in content courses. Using a …

On Problems In Random Structures, Ryan Cushman

Dissertations

This work addresses two problems in optimizing substructures within larger random structures. In the first, we study the triangle-packing number v(G), which is the maximum size of a set of edge-disjoint triangles in a graph. In particular we study this parameter for the random graph G(n,m). We analyze a random process called the online triangle packing process in order to bound v(G). The lower bound on v(G(n,m)) that this produces allows for the verification of a conjecture of Tuza for G( …

An Integrated Approach For The Assessment And Monitoring Of Land Deformation In The Riyadh City And Its Surroundings For Identifying The Controlling Factors, Abdulaziz Ibrahim Aljammaz

Dissertations

An integrated approach (remote sensing, field, geodesy, geology, and hydrogeology) was conducted to assess and monitor land deformation at Riyadh city and its surroundings. Two settings were investigated. The first, Jinadriyah area (1.5 km²), an urban area located east of Riyadh city, was selected to assess deformation associated with urbanization over desert lands. The second location was Al Kharj area (19,790 km²) to the south of Riyadh city, a reclaimed desert land that was selected to assess the deformation associated with agricultural groundwater extraction from fossil aquifers. My investigations revealed high subsidence rates (up to -30 …