Physical Sciences and Mathematics Commons^™

Mixture Models With Grouping Structure: Retail Analytics Applications, Haidar Almohri

Wayne State University Dissertations

Growing competitiveness and increasing availability of data is generating tremendous interest in data-driven analytics across industries. In the retail sector, stores need targeted guidance to improve both the efficiency and effectiveness of individual stores based on their specific location, demographics, and environment. We propose an effective data-driven framework for internal benchmarking that can lead to targeted guidance for individual stores. In particular, we propose an objective method for segmenting stores using a model-based clustering technique that accounts for similarity in store performance dynamics. It relies on effective Finite Mixture of Regression (FMR) techniques for carrying out the model-based clustering with …

3d Face Reconstruction And Emotion Analytics With Part-Based Morphable Models, Hai Jin

Wayne State University Dissertations

3D face reconstruction and facial expression analytics using 3D facial data are new

and hot research topics in computer graphics and computer vision. In this proposal, we first

review the background knowledge for emotion analytics using 3D morphable face model, including

geometry feature-based methods, statistic model-based methods and more advanced

deep learning-bade methods. Then, we introduce a novel 3D face modeling and reconstruction

solution that robustly and accurately acquires 3D face models from a couple of images

captured by a single smartphone camera. Two selfie photos of a subject taken from the

front and side are used to guide our …

A Comparison Of Discriminant Function Analysis And Logistic Regression By Categorizing The Incarcerated Mentally Ill, Mona King

Wayne State University Dissertations

Both discriminant function analysis (DFA) and logistic regression (LR) are used to classify subjects into a category/group based upon several explanatory variables (Liong & Foo, 2013). Although the two procedures are generally related, there is no clear advice in the statistical literature on when to use DFA vs. LR, although LR appears to be preferred due to the claim that its underlying assumptions are more easily met (Liong & Foo, 2013). Although DFA and LR use different methods to accomplish their objectives, they can answer the same research questions (Antonogeorgos et al., 2009). This facilitates a practical comparison of their …

Sofie: Smart Operating System For Internet Of Everything, Jie Cao

Wayne State University Dissertations

The proliferation of Internet of Things and the success of rich cloud services have pushed the

horizon of a new computing paradigm, Edge computing, which calls for processing the data at

the edge of the network. Applications such as cloud offloading, smart home, and smart city

are idea area for Edge computing to achieve better performance than cloud computing. Edge

computing has the potential to address the concerns of response time requirement, battery life

constraint, bandwidth cost saving, as well as data safety and privacy.

However, there are still some challenges for applying Edge computing in our daily life. The …

Uncertainty In Combustion Reaction Rates And Its Effects On Combustion Simulations, Joshua Piehl

Wayne State University Theses

This work investigates the uncertainties in reaction rates of an n-dodecane model on turbulent spray combustion simulations. Six major reactions were found to significantly impact the ignition delay of the mechanism in a 0-D batch reactor model. These reactions’ rates were independently modified and placed into individual mechanisms. These newly developed mechanisms were simulated in a 3-D turbulent spray simulation and a 0-D batch reactor at a pressure of 60 bar and temperatures from 900 to 1100 K. The combustion characteristics (e.g. ignition delays, flame lift-off length, liquid and vapor penetration) of the modified mechanisms were compared to those produced …

Kilovoltage Intensity Modulated Radiotherapy, Brian Loughery

Wayne State University Dissertations

Contrast enhanced kilovoltage radiotherapy could be a significant improvement over the standard of care in glioblastoma multiforme, but its potential benefit has been hindered by fears of insufficient dose falloff, high skin and skull dose, contrast delivery concerns, and high cost. This dissertation aims to address the validity of these fears.

Contrast delivery concerns are examined by assuming that sufficient dose can be safely delivered to the tumor. Iodine, gadolinium, and gold nanoparticle biological effect and delivery research is examined and the ideal contrast delivery methods are reported. Dose falloff and skull dose are then investigated through treatment planning and …

Design Of Ruthenium(Ii) Polypyridyl Complexes For Effectively Caging Nitriles And Aromatic Heterocycles, Ao Li

Wayne State University Dissertations

ABSTRACT

DESIGN OF RUTHENIUM(II) POLYPYRIDYL COMPLEXES FOR EFFECTIVELY CAGING NITRILES

AND AROMATIC HETEROCYCLES

by

AO LI

May 2018

Advisor: Dr. Jeremy Kodanko

Major: Chemistry

Degree: Doctor of Philosophy

Ru(II) polypyridyl complexes have been frequently employed in the caging and photorelease of biologically active compounds. Traditional photocaging groups derived from Ru(II) have been largely based on bi- or tridentate ancillary ligands, and those bearing ancillary ligands with high-denticities are yet to be developed. Exploring Ru(II) polypyridyl complexes possessing ancillary ligands with high-denticities provides insight into the photophysical and photochemical properties of ruthenium complexes, which creates novel prospects in the design of …

Switching Diffusion Systems With Past-Dependent Switching Having A Countable State Space, Hai Dang Nguyen

Wayne State University Dissertations

Emerging and existing applications in wireless communications, queueing networks, biological models, financial engineering, and social networks demand the

mathematical modeling and analysis of hybrid models in which continuous dynamics and discrete events coexist.

Assuming that the systems are in continuous times,

stemming from stochastic-differential-equation-based models and random discrete events,

switching diffusions come into being. In such systems, continuous states and discrete events

(discrete states)

coexist and interact.

A switching diffusion is a two-component process $(X(t),\alpha(t))$, a continuous component and a discrete component taking values in a discrete set (a set consisting of isolated points).

When the discrete component takes a …

Doped And Chemically Transformed Transition Metal Dichalcogenides (Tmdcs) For Two-Dimensional (2d) Electronics, Sagar Prasad Paudel

Wayne State University Dissertations

Transition metal dichalcogenides (TMDCs) as the semiconductor counterparts of gra-phene have emerged as promising channel materials for flexible electronic and optoelectronic devices. The 2D layer structure of TMDCs enables the ultimate scaling of TMDC-based devices down to atomic thickness. Furthermore, the absence of dangling bonds in these materials helps to form high quality heterostructures with ultra-clean interfaces. The main objective of this work is to develop novel approaches to fabricating TMDC-based 2D electronic devices such as diodes and transistors. In the first part, we have fabricated 2D p-n junction diodes through van der Waals assembly of heavily p-doped MoS2 (WSe2) …

Functional Study Of Smyd2 Glutathionylation In Cardiomyocytes, Dhanushka Nalin Perera Munkanatta Godage

Wayne State University Dissertations

Reactive oxygen species (ROS) are important signaling molecules that contribute to the etiology of multiple muscle-related diseases, including cardiomyopathy and heart failure. There is emerging evidence that cellular stress can lead to destabilization of sarcomeres, the contractile unit of muscle. However, it is not completely understood how cellular stress or ROS induce structural destabilization of sarcomeres or myofibrils. Protein glutathionylation is one of the major protein cysteine oxidative modifications that play an important role in redox signaling and oxidative stress. In this report, we used a clickable glutathione approach in a cardiomyocyte cell line, and found that SET and MYND …

Integrated Strategies For Sustainable Wastewater-Based Algal Biofuel Production And Environmental Mitigation In The Us, Javad Roostaei

Wayne State University Dissertations

Integration of algae cultivation with wastewater treatment has received increasing interest as a cost-effective strategy for biofuel production. However, there has been no full assessment of algal biofuel production with wastewater on macro-scale by taking into account wastewater resources, land availability, CO2 emission resources, and geographic variation. This research addressed and evaluated the use of wastewater for algae cultivation, in terms of modeling and laboratory experiments. The first goal of this research was to develop a spatially explicit lifecycle model, by integrating life cycle assessment (LCA), and Geographic Information Systems (GIS) analysis, for the evaluation of the environmental and economic …

Magnetic Moment And Susceptibility Quantification In Mri: Additional Frequency Shifts From Materials And Background Phase Removal Using A Reference Phantom, He Xie

Wayne State University Dissertations

The first part of this thesis was to utilize existing methods to remove the unwanted background phase from phantom studies. Magnetic moments of straws filled by three different materials (gadolinium, ferritin, and nanoparticles) with four different concentrations of each material were subsequently quantified at 10 different echo times, with straws perpendicular to the main magnetic field. As the radius of each straw was known, susceptibility was calculated from each measured magnetic moment. Results from different echo times agreed within uncertainties. In addition, near perfect linear relation between quantified susceptibility and concentration was obtained for each material. However, phase values inside …

Toward Better Keys For Lectin Locks: Glycoconjugates Versus Glycomimetics, Peng Wen

Wayne State University Dissertations

As one of the four major classes of macromolecule in living systems, the roles of carbohydrates as energy storage substances and structural components have long been recognized. However, the unique role of carbohydrates in cellular recognition processes has only been scrutinized since the 1960s, thanks to the progress in the research in both cell surface carbohydrates and carbohydrate-binding proteins (lectins). The advances in the research of such process demand the use of carbohydrates as basic tools. Therefore, the primary goal of glycochemistry has been to obtain complex carbohydrates and their analogs effectively. One common approach to the problem involves the …

Applications Of Molecular And Quantum Mechanical Methods For Studying The Chemical Reactions Of Inorganic And Organic Systems, Yi-Jung Tu

Wayne State University Dissertations

Computational studies can assist chemists to interpret experimental observations and to predict the properties and behaviors of molecules. The work presented in this dissertation applies different computational methods to study the molecular properties and reaction paths for various inorganic and organic systems. The second and third chapters discuss the force field development using “Gaussian Electrostatic Model (GEM)” and its amenability for use in the AMOEBA force field. The forth and fifth chapters discuss the density functional theory (DFT) studies of photodissociation behaviors for inorganic molecules. The sixth chapter explores the oxidation mechanisms of ascorbic acid and its antioxidant properties in …

Synthesis Of Volatile And Thermally Stable Aluminum Hydride Complexes And Their Use In Atomic Layer Deposition Of Metal Thin Films, Kyle Blakeney

Wayne State University Dissertations

The research discussed in this dissertation spans both synthetic inorganic and nanomaterials chemistry. Aluminum hydride complexes have been synthesized and characterized which are highly volatile and thermally stable and their potential as reducing agents for ALD of electropositive metal and metal-containing films was evaluated. A major discovery has been the deposition of aluminum metal films by thermal ALD using an aluminum dihydride complex supported by a simple amido-amine ligand (Chapters 2). Aluminum is the most electropositive element deposited by purely thermal ALD to date and represents a significant breakthrough for this field. This process may have important industrial applications and …

Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad

Wayne State University Dissertations

Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm. …

3d Momentum Imaging Spectroscopy Probing Of Strong-Field Molecular And Surface Dynamics, Lin Fan

Wayne State University Dissertations

Electron-ion coincidence measurements in combination with 3-dimensional (3D) momentum imaging can provide comprehensive 3D-momentum information to unravel multichannel photoionization/dissociation processes, and thus is an effective tool to investigate atomic/molecular dynamics. A camera-based 3D coincidence momentum imaging system and the velocity mapping imaging (VMI) based machine were introduced in Chapter 2. Studies of strong field dissociative single and double ionization of relatively large molecules camphor and 2-phenylethyl-N, N-dimethylamine (PENNA) were carried out and illustrated in Chapter 3. We demonstrated the main products of double ionization of PENNA were singlet diradicals. In Chapter 4, a novel angle resolved-photoemission spectroscopy based on VMI …

Design And Synthesis Of Oligo-(3,5-Dithio-Β-D-Glucopyranoside) As Β-(1→3)-Glucan Mimetics, Xiaoxiao Liao

Wayne State University Dissertations

This dissertation presents the design and synthesis of oligo-(3,5-dithio-β-D-glucopyranoside) as β-(1 → 3)-D-glucan mimetics. The synthesized dimeric, trimeric and tetrameric mimetics were tested for their binding affinities to Dectin-1 and CR3 and their abilities to activate phagocytosis and pinocytosis.

The first chapter gives an introduction of β-(1 → 3)-D-glucan. It gives an introduction about the structure and origin of β-(1 → 3)-D-glucan as well as the immunostimulating effect of natural β-(1 → 3)-D-glucan. The study of interaction between β-(1 → 3)-D-glucan and the receptors leads to a conclusion that the hydrophobicity of β-(1 → 3)-D-glucan is crucial to its immunostimulating …

Characterization Of Protonated Modified Nucleosides And Amino Acid-Linked Cisplatin Analogues Using Tandem Mass Spectrometry Complemented By Theoreticical Approaches, Chenchen He

Wayne State University Dissertations

The chemical difference between DNA and RNA nucleosides is their 2′-hydrogen versus 2′-hydroxyl substituents. The 2′-O-methylation is common among natural posttranscriptional modifications of RNA. The structures and relative glycosidic bond stabilities of the protonated forms of the 2′-O-methylated nucleosides, 2′-O-methyladenosine (Adom), 2′-O-methylguanosine (Guom), 2′-O-methycytidine (Cydm), 2′-O-methyluridine (Urdm), and 5,2′-O-dimethyluridine (Thdm) are examined using two complementary tandem mass spectrometry approaches, infrared multiple photon dissociation (IRMPD) action spectroscopy and energy-resolved collision-induced dissociation (ER-CID). Theoretical calculations are also performed to predict the structures and relative stabilities of stable low-energy conformations of the protonated forms of the 2′-O-methylated nucleosides and their infrared spectra in …

Representation Learning With Convolutional Neural Networks, Haotian Xu

Wayne State University Dissertations

Deep learning methods have achieved great success in the areas of Computer Vision and Natural Language Processing. Recently, the rapidly developing field of deep learning is concerned with questions surrounding how we can learn meaningful and effective representations of data. This is because the performance of machine learning approaches is heavily dependent on the choice and quality of data representation, and different kinds of representation entangle and hide the different explanatory factors of variation behind the data.

In this dissertation, we focus on representation learning with deep neural networks for different data formats including text, 3D polygon shapes, and brain …

Modification Of 4,5- Aminoglycosides To Overcome Drug Resistance Bacteria And Toxic Side Effect, Guanyu Yang

Wayne State University Dissertations

ABSTRACT

MODIFICATION OF 4,5- AMINOGLYCOSIDES TO OVERCOME DRUG RESISTANCE BACTERIA AND TOXIC SIDE EFFECT

by

Guanyu Yang

September 2018

Advisor: Professor David Crich

Major: Chemistry

Degree: Doctor of Philosophy

Infectious diseases causing by antibiotic resistant pathogen are one of the major threat to human health and society today. Many researchers tried to develop next generation of antibiotics by reinvesting the existing antibacterial drugs. Aminoglycosides have long been used as highly potent and broad-spectrum antibiotics for treating bacterial infections. But their side effect, especially the irreversible ototoxicity, and the fast-growing resistant problem limit their application. The goal of this research was …

Stereoselective Synthesis Of Legionaminic Acid And Pseudaminic Acid Glycosides, Bibek Dhakal

Wayne State University Dissertations

Legionaminic acid (Leg) and pseudaminic acid (Pse) are deoxy acetamido analogues of the most common sialic acid, N-acetylneuraminic acid (NeuAc) that are found in microorganisms. Leg and Pse are rare but important class of sialic acids, as their glycosides are found in lipopolysaccharides and glycoproteins of several pathogenic Gram-negative bacteria including Pseudomonas aeruginosa, Legionella pneumophila serogroup 1, Campylobacter jejuni, and Campylobacter coli. As such, the stereoselective glycosylation of the equatorial Leg and Pse donors, and the role played by their side chain conformations in anomeric reactivity and selectivity are the focus of this thesis.

Chapter two describes the synthesis of …

Hydroxylamines And Hydrazines As Surrogates Of Sp3 Carbons In Medicinal Chemistry, Sandeep Dhanju

Wayne State University Dissertations

Current compound libraries that are used in high-throughput screening (HTS) are populated by low molecular weight and relatively planar compounds with high sp2 character and little stereochemical complexity. Unfortunately, such planar compounds cover only a very small corner of chemical space. In order to increase the diversity, structurally complex molecules with high fractions of sp3-hybridized atoms should be included in compound libraries. However, generating a large number of architecturally complex molecules using the current organic synthesis toolbox is considered tedious due to the requirement of multi-step synthesis. Recognizing this need, several creative strategies, like diversity-oriented synthesis, have been developed with …

Addressing The Proton Radius Puzzle Using Qed-Nrqed Effective Field Theory, Steven Patrick Dye

Wayne State University Dissertations

In 2010 the first extraction of the proton charge radius from muonic hydrogen was found to be five standard deviations away from the regular hydrogen value. Seven years later, this proton radius puzzle still persists, and challenges our understanding of the structure of the proton. An effective field theory analysis using Non-Relativistic Quantum Electrody- namics (NRQED) indicates that the muonic hydrogen result can be interpreted as a large, compared to some model estimates, muon-proton spin-independent contact interaction. The muonic hydrogen result can be tested by a muon-proton scattering experiment, MUSE, that is planned at the Paul Scherrer Institute in Switzerland. …

Polarized Localization Microscopy (Plm) Detects Nanoscale Membrane Curvature And Induced Budding By Cholera Toxin Subunit B (Ctxb), Abir Kabbani

Wayne State University Dissertations

The curvature of biological membranes at the nanometer scale is critically important for vesicle trafficking, organelle morphology, and disease propagation. Many proteins and lipids interact with diverse curvature sensing and curvature generating mechanisms. Deciphering the molecular mechanisms of toxin-membrane interactions has been limited by the resolution and drawbacks of conventional experimental techniques. This study reveals the inherent membrane bending capability of cholera toxin subunit B (CTxB) through the development and implementation of Polarized Localization Microscopy (PLM). PLM is a pointillist optical imaging technique for the detection of nanoscale membrane curvature in correlation with single-molecule dynamics and molecular sorting.

PLM combines …

Predictable Reliability In Inter-Vehicle Communications, Chuan Li

Wayne State University Dissertations

Predictably reliable communication in wireless networked sensing and control systems (WSC) is a basic enabler for performance guarantee. Yet current research efforts are either focus on maximizing throughput or based on inaccurate interference modelling methods, which yield unsatisfactory results in terms of communication reliability. In this dissertation, we discuss techniques that enable reliable communication in both traditional wireless sensor networks and highly mobile inter-vehicle communication networks. We focus our discussion on traditional wireless sensor networks in Chapter 2 where we discuss mechanisms that enable predictable and reliable communications with no centralized infrastructures. With the promising results in Chapter 2, we …

Hardy Space Theory And Endpoint Estimates For Multi-Parameter Singular Radon Transforms, Jiawei Shen

Wayne State University Dissertations

In [12], Christ, Nagel, Stein and Waigner studied the L p theories for the singular Radon Trans-

forms. Furthermore, B. Street in [68], and Stein and Street in [64–67] extended the theories of the

L p boundedness for multi-parameter singular integral operators, such as the Calderón Zygmund

operators and singular Radon transforms. In this dissertation, we will study the Hardy space H p

and its dual space associated with both the one-parameter and multi-parameter singular Radon

transforms, and consider the boundedness of the singular Radon transforms on such Hardy spaces

H p when 0 ≤ p ≤ 1.

Inspired by …

Scalable And Secure Provenance Querying For Scientific Workflows And Its Application In Autism Study, Fahima Amin Bhuyan

Wayne State University Dissertations

In the era of big data, scientific workflows have become essential to automate scientific experiments and guarantee repeatability. As both data and workflow increase in their scale, requirements for having a data lineage management system commensurate with the complexity of the workflow also become necessary, calling for new scalable storage, query, and analytics infrastructure. This system that manages and preserves the derivation history and morphosis of data, known as provenance system, is essential for maintaining quality and trustworthiness of data products and ensuring reproducibility of scientific discoveries. With a flurry of research and increased adoption of scientific workflows in processing …

Chemical And Physical Studies Of Charge Transfer Excited States Of Ruthenium Complexes With Aromatic Ligands, Marim Khalifa Alnaed

Wayne State University Dissertations

The 3MLCT excited states generated from tris-bipyridineruthenium(II), [Ru(bpy)3]2+ and related complexes was ionized by 405 nm irradiation in ambient, acidic aqueous solutions. The photoionization product was Ru(bpy)3]3+ and an electron with a quantum yield of about 0.040.02 in 0.5 M acid. However, 532 nm radiation does not induce photoionization, and it generates the 3MLCT excited state that can be photoionized by 405 nm irradiation. The proton is a very good electron scavenger, and the rate of phoionization of the 3MLCT excited state was determined to be acid dependent and it increased about ten-fold for acid concentrations beween 0.001 and 4 …

Carbazole Based Multifunctional Dopamine Agonists And Related Molecules As Potential Symptomatic And Disease Modifying Therapeutic Agents For Parkinson’S Disease, Asma S.Mohamed Elmabruk

Wayne State University Dissertations

Parkinson’s disease (PD) is a progressive neurodegenerative disease that develops from gradual depletion of dopamine (DA) and dopaminergic neurons in the substantia nigra pars compacta (SNc) with the accumulation of intraneuronal proteinaceous matter named as Lewy bodies. The four cardinal symptoms associated with PD are tremor, rigidity, bradykinesia, and postural instability. Although the exact mechanism and etiology of PD are not fully understood, several factors have been implicated in the pathogenesis and progression of PD including protein aggregation, oxidative stress, mitochondrial dysfunction, environmental, and genetic factors.

The current therapy of Parkinson’s disease is categorized into four classes: levodopa, DA agonists, …