Physical Sciences and Mathematics Commons^™

Kilovoltage Intensity Modulated Radiotherapy, Brian Loughery

Wayne State University Dissertations

Contrast enhanced kilovoltage radiotherapy could be a significant improvement over the standard of care in glioblastoma multiforme, but its potential benefit has been hindered by fears of insufficient dose falloff, high skin and skull dose, contrast delivery concerns, and high cost. This dissertation aims to address the validity of these fears.

Contrast delivery concerns are examined by assuming that sufficient dose can be safely delivered to the tumor. Iodine, gadolinium, and gold nanoparticle biological effect and delivery research is examined and the ideal contrast delivery methods are reported. Dose falloff and skull dose are then investigated through treatment planning and …

Doped And Chemically Transformed Transition Metal Dichalcogenides (Tmdcs) For Two-Dimensional (2d) Electronics, Sagar Prasad Paudel

Wayne State University Dissertations

Transition metal dichalcogenides (TMDCs) as the semiconductor counterparts of gra-phene have emerged as promising channel materials for flexible electronic and optoelectronic devices. The 2D layer structure of TMDCs enables the ultimate scaling of TMDC-based devices down to atomic thickness. Furthermore, the absence of dangling bonds in these materials helps to form high quality heterostructures with ultra-clean interfaces. The main objective of this work is to develop novel approaches to fabricating TMDC-based 2D electronic devices such as diodes and transistors. In the first part, we have fabricated 2D p-n junction diodes through van der Waals assembly of heavily p-doped MoS2 (WSe2) …

Magnetic Moment And Susceptibility Quantification In Mri: Additional Frequency Shifts From Materials And Background Phase Removal Using A Reference Phantom, He Xie

Wayne State University Dissertations

The first part of this thesis was to utilize existing methods to remove the unwanted background phase from phantom studies. Magnetic moments of straws filled by three different materials (gadolinium, ferritin, and nanoparticles) with four different concentrations of each material were subsequently quantified at 10 different echo times, with straws perpendicular to the main magnetic field. As the radius of each straw was known, susceptibility was calculated from each measured magnetic moment. Results from different echo times agreed within uncertainties. In addition, near perfect linear relation between quantified susceptibility and concentration was obtained for each material. However, phase values inside …

Addressing The Proton Radius Puzzle Using Qed-Nrqed Effective Field Theory, Steven Patrick Dye

Wayne State University Dissertations

In 2010 the first extraction of the proton charge radius from muonic hydrogen was found to be five standard deviations away from the regular hydrogen value. Seven years later, this proton radius puzzle still persists, and challenges our understanding of the structure of the proton. An effective field theory analysis using Non-Relativistic Quantum Electrody- namics (NRQED) indicates that the muonic hydrogen result can be interpreted as a large, compared to some model estimates, muon-proton spin-independent contact interaction. The muonic hydrogen result can be tested by a muon-proton scattering experiment, MUSE, that is planned at the Paul Scherrer Institute in Switzerland. …

Polarized Localization Microscopy (Plm) Detects Nanoscale Membrane Curvature And Induced Budding By Cholera Toxin Subunit B (Ctxb), Abir Kabbani

Wayne State University Dissertations

The curvature of biological membranes at the nanometer scale is critically important for vesicle trafficking, organelle morphology, and disease propagation. Many proteins and lipids interact with diverse curvature sensing and curvature generating mechanisms. Deciphering the molecular mechanisms of toxin-membrane interactions has been limited by the resolution and drawbacks of conventional experimental techniques. This study reveals the inherent membrane bending capability of cholera toxin subunit B (CTxB) through the development and implementation of Polarized Localization Microscopy (PLM). PLM is a pointillist optical imaging technique for the detection of nanoscale membrane curvature in correlation with single-molecule dynamics and molecular sorting.

PLM combines …

Identification Of Streptococcus Pyogenes Using Raman Spectroscopy, Ehsan Majidi

Wayne State University Dissertations

Despite the attention that Raman Spectroscopy has gained recently in the area of pathogen identification, the spectra analyses techniques are not well developed. In most scenarios, they rely on expert intervention to detect and assign the peaks of the spectra to specific molecular vibration. Although some investigators have used machine-learning techniques to classify pathogens, these studies are usually limited to a specific application, and the generalization of these techniques is not clear. Also, a wide range of algorithms have been developed for classification problems, however, there is less insight to applying such methods on Raman spectra. Furthermore, analyzing the Raman …

Applications Of Effective Field Theories To New Physics, Derek Edward Hazard

Wayne State University Dissertations

We apply an effective field theory approach and argue that lepton flavor violating (LFV) decays M → l1l2 of meson states M with different quantum numbers could be used to put constraints on the Wilson coefficients of effective operators describing LFV interactions at low energy scales. We note that the restricted kinematics of the two-body decay of quarkonium or a heavy quark meson allows us to select operators with particular quantum numbers, significantly reducing the reliance on the single operator dominance assumption that is prevalent in constraining parameters of the effective LFV Lagrangian. We shall also argue that studies of …