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Full-Text Articles in Physical Sciences and Mathematics
A Nonlinear Systems Framework For Cyberattack Prevention For Chemical Process Control Systems, Helen Durand
A Nonlinear Systems Framework For Cyberattack Prevention For Chemical Process Control Systems, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Recent cyberattacks against industrial control systems highlight the criticality of preventing future attacks from disrupting plants economically or, more critically, from impacting plant safety. This work develops a nonlinear systems framework for understanding cyberattack-resilience of process and control designs and indicates through an analysis of three control designs how control laws can be inspected for this property. A chemical process example illustrates that control approaches intended for cyberattack prevention which seem intuitive are not cyberattack-resilient unless they meet the requirements of a nonlinear systems description of this property.
State Measurement Spoofing Prevention Through Model Predictive Control Design, Helen Durand
State Measurement Spoofing Prevention Through Model Predictive Control Design, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Security of chemical process control systems against cyberattacks is critical due to the potential for injuries and loss of life when chemical process systems fail. A potential means by which process control systems may be attacked is through the manipulation of the measurements received by the controller. One approach for addressing this is to design controllers that make manipulating the measurements received by the controller in any meaningful fashion very difficult, making the controllers a less attractive target for a cyberattack of this type. In this work, we develop a model predictive control (MPC) implementation strategy that incorporates Lyapunov-based stability …
Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski
Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski
Wayne State University Dissertations
Lung cancer remains the leading cause of cancer-related deaths in the United States. Secondary lung tumors metastasized from other cancer sites also remains highly prevalent, in which most metastatic tumors cannot be cured with existing therapies. Chemoresistance (multi drug resistance – MDR) that develops intrinsically or acquired is one of the key factors leading to fatality in these patients. MDR develops form a variety of resistance mechanisms that can occur consecutively or concurrently, therefore, making most current treatments unsuccessful. Current therapies have known to slow tumor growth, but rarely provide a cure. Immunotherapy has seen some promise, including the use …