Physical Sciences and Mathematics Commons^™

Novel Concepts In Semiconductor Disk Lasers, Zhou Yang

Optical Science and Engineering ETDs

Optically-pumped semiconductor disk lasers (SDLs) have received much attention in recent years for a myriad of applications requiring intracavity access, good beam quality, wavelength versatility, and high output powers. The traditional scheme of these lasers feature a semiconductor distributed Bragg reflector (DBR) integrated with the active region, together forming an active mirror in an external free-space cavity. The active mirror component is fabricated by either epitaxial growth or post-growth processing. This places certain restrictions on SDL design, as material system choices become limited. It further viii hinders laser performance with regard to its thermal management and laser bandwidth (tuning range). …

What Affects Parents’ Choice Of Milk? An Application Of Bayesian Model Averaging, Yingzhe Cheng

Mathematics & Statistics ETDs

This study identifies the factors that influence parents’ choice of milk for their children, using data from a unique survey administered in 2013 in Hunan province, China. In this survey, we identified two brands of milk, which differ in their prices and safety claims by the producer. Data were collected on parents’ choice of milk between the two brands, demographics, attitude towards food safety and behaviors related to food. Stepwise model selection and Bayesian model averaging (BMA) are used to search for influential factors. The two approaches consistently select the same factors suggested by an economic theoretical model, including price …

Efficient And Robust Methods For Quantum Tomography, Charles Baldwin

Physics & Astronomy ETDs

The development of large-scale platforms that implement quantum information processing protocols requires new methods for verification and validation of quantum behavior. Quantum tomography (QT) is the standard tool for diagnosing quantum states, process, and readout devices by providing complete information about each. However, QT is limited since it is expensive to not only implement experimentally, but also requires heavy classical post-processing of experimental data. In this dissertation, we introduce new methods for QT that are more efficient to implement and robust to noise and errors, thereby making QT a more widely practical tool for current quantum information experiments. The crucial …

Impacts Of Long-Term Precipitation Manipulation On Hydraulic Architecture, Xylem Function, And Canopy Status In A Piñon-Juniper Woodland, Patrick J. Hudson

Biology ETDs

The Southwestern US is predicted to become hotter and drier, as global climate change forces increasing temperatures and variability in timing and size of precipitation inputs. Drought stress has become more frequent in recent decades, and resulted in massive forest mortality in piñon-juniper woodlands. During recent severe droughts (2000-2003, 2009-2012), piñon pine (Pinus edulis Englem.) suffered disproportionately high mortality compared to co-occurring one-seed juniper (Juniperus monosperma [Engelm.] Sarg.). A large-scale precipitation manipulation experiment was established in a piñon-juniper woodland in central New Mexico to test hypotheses regarding tree survival and mortality with respect to altered water regimes. Our …

Mechanistic Plug-And-Play Models For Understanding The Impact Of Control And Climate On Seasonal Dengue Dynamics In Iquitos, Peru, Nathan Levick

Mathematics & Statistics ETDs

Dengue virus is a mosquito-borne multi-serotype disease whose dynamics are not precisely understood despite half of the world’s human population being at risk of infection. A recent dataset of dengue case reports from an isolated Amazonian city— Iquitos, Peru—provides a unique opportunity to assess dengue dynamics in a simpli- fied setting. Ten years of clinical surveillance data reveal a specific pattern: two novel serotypes, in turn, invaded and exclusively dominated incidence over several seasonal cycles, despite limited intra-annual variation in climate conditions. Together with mechanistic mathematical models, these data can provide an improved understand- ing of the nonlinear interactions between …

Single Particle Tracking: Analysis Techniques For Live Cell Nanoscopy., Peter K. Relich

Physics & Astronomy ETDs

Single molecule experiments are a set of experiments designed specifically to study the properties of individual molecules. It has only been in the last three decades where single molecule experiments have been applied to the life sciences; where they have been successfully implemented in systems biology for probing the behaviors of sub-cellular mechanisms. The advent and growth of super-resolution techniques in single molecule experiments has made the fundamental behaviors of light and the associated nano-probes a necessary concern among life scientists wishing to advance the state of human knowledge in biology. This dissertation disseminates some of the practices learned in …

Scatterometry Of 50 Nm Half Pitch Features, Ruichao Zhu

Optical Science and Engineering ETDs

Metrology technologies are an essential adjunct to Integrated Circuit (I.C.) Semiconductor manufacturing. Scatterometry, an optical metrology, was chosen to measure 50 nm half pitch feature structures. A bread-board scatterometry system has been assembled to provide a non-contact, non-destructive, accurate and flexible measurement. A real-time, on-line scatterometry system has also been demonstrated and proven to provide a high throughput measurement.

Three different types of samples have been measured using the scatterometry setup. The wire-grid polarizer (WGP) sample has been made by Jet and Flash Nanoimprint Lithography with ~100 nm pitch and ~50 nm wide ~200 nm tall Al gratings on fused …

New Insights Into The Martian Crust And Angrite Parent Body Through Meteorites, Alison R. Santos

Earth and Planetary Sciences ETDs

Petrologic studies of two new, unique meteorites were conducted in order to characterize the samples and provide insights into their parent bodies. The first sample, Northwest Africa 7034, is the first martian meteorite breccia to be discovered. In an effort to understand the martian crustal materials sampled by the breccia, we developed a classification scheme for the breccia clasts based on their texture, mineralogy, and chemistry. We then further investigated two clast groups which contained trends in mineralogy and chemistry that suggested a possible genetic relationship between the two. Our findings suggest they are not related by a simple igneous …

Memory Effects In Brownian Motion, Random Walks Under Confining Potentials, And Relaxation Of Quantum Systems, Matthew Chase

Physics & Astronomy ETDs

This dissertation is a report on a number of distinct topics in the field of non-equilibrium statistical mechanics including the evolution of classical as well as quantum systems.

The evolution of an object that is described by the Ornstein-Uhlenbeck process generalized through a time-nonlocal attraction is considered. The time-nonlocality is taken to be represented in the Langevin description through the presence of memory. Analysis of the Langevin equation is performed for algebraic and delay-type memories. An equivalent \emph{bona-fide} Fokker-Planck equation is constructed.

A random walker subjected to a non-standard confining potential, taken to be a piece-wise linear function, is analyzed. …

Extending The Reach Of Directional Dark Matter Experiments Through Novel Detector Technologies, Nguyen S. Phan

Physics & Astronomy ETDs

Dark matter is believed to comprise over 80% of the matter in the Universe. Its composition could be in the form of weakly interacting massive particles (WIMPs), which are predicted by extensions of the Standard Model, namely supersymmetric theories. Even though hints of its existence were detected in astronomical observations over eighty years ago, its detection through means other than the gravitational influence on observable luminous matter still eludes us.

Currently, there are many ongoing direct detection experiments, that aim to measure the signals left by the elastic scattering of WIMPs with nuclei in the detector target material. The detection …

Development Of In Vivo Systems For Detecting And Studying Ribosome Inhibition By Small Molecules, Shijie Huang

Chemistry and Chemical Biology ETDs

The ribosome is the quintessential antibacterial drug target, with many structurally and mechanistically distinct classes of antibacterial agents acting by inhibiting ribosome function. Detecting and quantifying ribosome inhibition by small molecules and investigating their binding modes and mechanisms of action are critical to antibacterial drug discovery and development efforts. To develop a ribosome inhibition assay that is operationally simple, yet provides direct information on the drug target and the mechanism of action, we have developed engineered E. coli strains harboring an orthogonal ribosome controlled green fluorescent protein reporter that produce fluorescent signal when the O-ribosome is inhibited. As a proof …

Development And Application Of An Expanded Streptomyces Genetic Code, Jingxuan He

Chemistry and Chemical Biology ETDs

Actinobacteria, especially those of genus Streptomyces, are a prominent source of bioactive natural products. The ability to site-specifically incorporate unnatural amino acids (UAAs) into natural product biosynthetic enzymes and ribosomally derived peptides in these organisms would constitute a valuable tool for drug discovery and development. The work described in this dissertation focuses on development and application of an expanded Streptomyces genetic code, including development of UAA incorporation systems based on amber suppression and sense codon reassignment, structural diversification of the model thiopeptide natural product thiostrepton using UAAs, and mapping protein-protein interactions in type II polyketide biosynthetic enzymes using photocrosslinking …

Network Inference Driven Drug Discovery, Gergely Zahoránszky-Kőhalmi, Tudor I. Oprea Md, Phd, Cristian G. Bologa Phd, Subramani Mani Md, Phd, Oleg Ursu Phd

Biomedical Sciences ETDs

The application of rational drug design principles in the era of network-pharmacology requires the investigation of drug-target and target-target interactions in order to design new drugs. The presented research was aimed at developing novel computational methods that enable the efficient analysis of complex biomedical data and to promote the hypothesis generation in the context of translational research. The three chapters of the Dissertation relate to various segments of drug discovery and development process.

The first chapter introduces the integrated predictive drug discovery platform „SmartGraph”. The novel collaborative-filtering based algorithm „Target Based Recommender (TBR)” was developed in the framework of this …

Theory And Practice Of Computing With Excitable Dynamics, Alireza Goudarzi

Computer Science ETDs

Reservoir computing (RC) is a promising paradigm for time series processing. In this paradigm, the desired output is computed by combining measurements of an excitable system that responds to time-dependent exogenous stimuli. The excitable system is called a reservoir and measurements of its state are combined using a readout layer to produce a target output. The power of RC is attributed to an emergent short-term memory in dynamical systems and has been analyzed mathematically for both linear and nonlinear dynamical systems. The theory of RC treats only the macroscopic properties of the reservoir, without reference to the underlying medium it …

Searching Neuroimaging Biomarkers In Mental Disorders With Graph And Multimodal Fusion Analysis Of Functional Connectivity, Hao He

Electrical and Computer Engineering ETDs

Mental disorders such as schizophrenia (SZ), bipolar (BD), and major depression disorders (MDD) can cause severe symptoms and life disruption. They share some symptoms, which can pose a major clinical challenge to their differentiation. Objective biomarkers based on neuroimaging may help to improve diagnostic accuracy and facilitate optimal treatment for patients. Over the last decades, non-invasive in-vivo neuroimaging techniques such as magnetic resonance imaging (MRI) have been increasingly applied to measure structure and function in human brains. With functional MRI (fMRI) or structural MRI (sMRI), studies have identified neurophysiological deficits in patients’ brain from different perspective. Functional connectivity (FC) analysis …

Engineering Small Molecule Based Dimerization To Induce Translation And Provide Optogenetic Control, Catherine Wright

Chemistry and Chemical Biology ETDs

We wanted to develop a system that combines the spatial control of photoactivation and control of translation to build a tool to spatially control translation in neurons. This kind of tool could be used to investigate the role of spatially controlled translation of any protein in neural behavior. In this way the development and growth of neural processes could be studied to elucidate the mechanisms for spatially sensitive events such as pathfinding, repair, or long-term potentiation.

Chemically induced dimerization was used to install a switch into the activation of translation for specific genes. An abscisic acid (ABA) dependent dimerization of …

Towards Deeper Understanding In Neuroimaging, Rex Devon Hjelm

Computer Science ETDs

Neuroimaging is a growing domain of research, with advances in machine learning having tremendous potential to expand understanding in neuroscience and improve public health. Deep neural networks have recently and rapidly achieved historic success in numerous domains, and as a consequence have completely redefined the landscape of automated learners, giving promise of significant advances in numerous domains of research. Despite recent advances and advantages over traditional machine learning methods, deep neural networks have yet to have permeated significantly into neuroscience studies, particularly as a tool for discovery. This dissertation presents well-established and novel tools for unsupervised learning which aid in …

Experimental Investigation Of Plasma Dynamics In Jets And Bubbles Using A Compact Coaxial Plasma Gun In A Background Magnetized Plasma, Yue Zhang

Electrical and Computer Engineering ETDs

Numerous solar and astrophysical observations of jet- and bubble-like plasma structures exhibit morphological similarities, suggesting that there may be common plasma physics at work in the formation and evolution processes of these structures at different system scales. The ideal magnetohydrodynamics (MHD) provide the necessary theoretical basis for employing laboratory experiments to investigate key physical processes in nonlinear astrophysical and solar systems, especially when magnetic fields are present.

A coaxial magnetized plasma gun has been designed, installed, and operated in the HelCat linear device at the University of New Mexico. In Region I, a current-driven plasma jet is formed. The plasma …

Probing Dark Matter-Neutrino Connection Via Indirect Detection Experiments, Bradley Knockel

Physics & Astronomy ETDs

Various evidence reveals that dark matter is a primary component of this universe. The amount of dark matter is known, but its identity is a mystery. To determine its properties, efforts to detect and produce dark matter are underway. Dark matter annihilations throughout the galaxy may produce photons, neutrinos, and cosmic rays. Neutrino and photon detectors may then indirectly detect dark matter by detecting these annihilation products. The annihilation rate, dark matter mass, and dark matter scattering rate off of matter affect the signals received at Earth. These signals can therefore probe the identity of dark matter, especially if dark …

Abrupt Ocean Anoxia During The Late Ordovician Mass Extinction Detected Using Uranium Isotopes Of Marine Carbonates, Rickey Bartlett, Maya Elrick, Yemane Asmerom, Viorel Atudorei

Earth and Planetary Sciences ETDs

The Ordovician witnessed an explosion in marine biodiversity punctuated by the first of the ‘big-5’ Phanerozoic mass extinctions, the Late Ordovician mass extinction (LOME). The LOME consists of two discrete pulses occurring at the beginning and end of the Hirnantian. Lithologic and geochemical evidence suggests widespread marine anoxia triggered the second LOME pulse; however, most of these redox proxies record local bottom water or porewater conditions rather than global seawater conditions. To evaluate global redox trends, we utilize uranium (U) isotopes and trace element geochemistry of marine carbonates as a global marine redox proxy.

Bulk carbonate samples were collected from …

High Power Optically Pumped Semiconductor Lasers For Sodium Guidestar Applications, Shawn W. Hackett

Optical Science and Engineering ETDs

Optically pumped semiconductor lasers (OPSLs) are shown to provide a much more compact and less expensive source for illumination of the sodium layer of the mesosphere for use as a sodium laser guidestar via single and two photon excitation schemes. This represents a revolution in laser guidestar technology as the cost, size, and power requirements for a laser guidestar system are shown to have been decreased by an order of magnitude with guidestar performance shown to be similar to previous sources. Sodium laser guidestar sources for broadband simultaneous illumination of multiple lines are developed and simulated. Simulations are then compared …

Molecular Tetrapods For Optoelectronic Applications, Jianzhong Yang

Chemistry and Chemical Biology ETDs

In this dissertation, several molecular tetrapods were synthesized for optoelectronic applications. In the first two sections, two tetrapodal breakwater-like small molecules: SO and SFBTD were synthesized and characterized. Absorption, X-ray scattering and differential scanning calorimetry experiments indicate crystalline nature of these compounds but slow crystallization kinetics. Solar cells employing SO or SFBTD and phenyl-C₆₁-butyric acid methyl ester (PCBM) were fabricated and evaluated. Relatively low performance was obtained mainly due to the lack of appropriate phase separation, which was caused by molecularly mixed blends with PCBM. The molecularly mixed blends is the result of slow crystallization …

Csp And “Omics” Technology Applied On Versatile And Intelligent Portable Platform For Modeling Complex Bio-Medical Data, Florentin Smarandache, Luige Vladareanu, Mihaiela Iliescu, Hongbo Wang, Feng Yongfei, Victor Vladareanu

Branch Mathematics and Statistics Faculty and Staff Publications

This paper presents relevant aspects of the idea of using the digital medicine in cancer, so that to shape a viable strategy for creating and implementing an interactive digital platform, NEO-VIP, that should be the basic support to design the strategy for integration of basic, clinical and environmental research on neoplasia progression to cancer. The two main components of the VIPRO Platform are represented by the workstation “Engineering Station” for CPS (Cyber Physical System) and “omics” technology and by the “Graphical Station” for the development of a virtual mechatronic system environment and virtual reality for system components' motion. The NEO-VIP …

Computation Of Shortest Path Problem In A Network With Sv-Trapezoidal Neutrosophic Numbers, Florentin Smarandache, Said Broumi, Assia Bakali, Mohamed Talea, Luige Vladareanu

Branch Mathematics and Statistics Faculty and Staff Publications

In this work, a neutrosophic network method is proposed for finding the shortest path length with single valued trapezoidal neutrosophic number. The proposed algorithm gives the shortest path length using score function from source node to destination node. Here the weights of the edges are considered to be single valued trapezoidal neutrosophic number. Finally, a numerical example is used to illustrate the efficiency of the proposed approach

Advanced Data Analysis - Lecture Notes, Erik B. Erhardt, Edward J. Bedrick, Ronald M. Schrader

Open Textbooks

Lecture notes for Advanced Data Analysis (ADA1 Stat 427/527 and ADA2 Stat 428/528), Department of Mathematics and Statistics, University of New Mexico, Fall 2016-Spring 2017. Additional material including RMarkdown templates for in-class and homework exercises, datasets, R code, and video lectures are available on the course websites: https://statacumen.com/teaching/ada1 and https://statacumen.com/teaching/ada2 .

Contents

I ADA1: Software

• 0 Introduction to R, Rstudio, and ggplot

II ADA1: Summaries and displays, and one-, two-, and many-way tests of means

• 1 Summarizing and Displaying Data
• 2 Estimation in One-Sample Problems
• 3 Two-Sample Inferences
• 4 Checking Assumptions
• 5 One-Way Analysis of Variance

III ADA1: Nonparametric, categorical, …

Birth And Evolution Of The Rio Grande Fluvial System In The Last 8 Ma:Progressive Downward Integration And Interplay Between Tectonics, Volcanism, Climate, And River Evolution, Marisa N. Repasch

Earth and Planetary Sciences ETDs

The Rio Grande-Rio Chama (RG-RC) fluvial system has evolved dramatically over the last 8 Ma, undergoing channel migrations, drainage capture and integration events, volcanic damming, and carving and refilling of paleocanyons. Volcanism concurrent with the development of the river system provides a unique opportunity to apply multiple geochronometers to the study of its incision and drainage evolution. This paper reports 19 new ⁴⁰Ar/³⁹Ar basalt ages and 19 detrital mineral samples (zircon and sanidine) collected from RG-RC alluvium overlain by dated basalt flows in the context of a compilation of published ⁴⁰Ar/³⁹Ar basalt ages. The …

University Of New Mexico Bioalgal Energy, Photosynthesis Rates Of Poplar Plants - Measurements With Tdl Machine (Enriched Co2 - Enriched-Exposed - Tray 10 - Play 3 - 2016/06/15), David Hanson

Energize New Mexico (NSF EPSCoR Track 1 IV)

Collect the photosynthetic rate of poplar plants under different isotopic compositions of CO2 with the TDL machine and with the Licor equipment.

University Of New Mexico Bioalgal Energy, Photosynthesis Rates Of Poplar Plants - Measurements With Tdl Machine (Enriched Co2 - Enriched-Exposed - Tray 1/2 - Play 3 - 2016/06/12), David Hanson

Energize New Mexico (NSF EPSCoR Track 1 IV)

Collect the photosynthetic rate of poplar plants under different isotopic compositions of CO2 with the TDL machine and with the Licor equipment.

University Of New Mexico Bioalgal Energy, Photosynthesis Rates Of Poplar Plants - Measurements With Tdl Machine (Enriched Co2 - Enriched-Exposed - Tray 1/3 - Play 1 - 2016/06/08), David Hanson

Energize New Mexico (NSF EPSCoR Track 1 IV)

Collect the photosynthetic rate of poplar plants under different isotopic compositions of CO2 with the TDL machine and with the Licor equipment.

University Of New Mexico Bioalgal Energy, Photosynthesis Rates Of Poplar Plants - Measurements With Tdl Machine (Enriched Co2 - Enriched-Exposed - Tray 10 - Play 2 - 2016/06/14), David Hanson

Energize New Mexico (NSF EPSCoR Track 1 IV)

Collect the photosynthetic rate of poplar plants under different isotopic compositions of CO2 with the TDL machine and with the Licor equipment.