Physical Sciences and Mathematics Commons^™

Per-Contact Infectivity Of Hcv Associated With Injection Exposures In A Prospective Cohort Of Young Injection Drug Users In San Francisco, Ca (Ufo Study), Yuridia Leyva

Mathematics & Statistics ETDs

Sharing needles and ancillary injection drug equipment places injection drug users (IDU) at risk for Hepatitis C Virus (HCV), a highly infectious blood-borne virus. A limited number of studies have analyzed the per-contact infectivity of HCV associated with the use of previously-used needles, but per-contact infectivity of ancillary injecting equipment has not been previously investigated. Our goal is to estimate the per-contact infectivity of HCV associated with (1) injecting with another person's previously-used needle, classified as receptive needle sharing (RNS), and (2) using another person's previously-used ancillary injecting equipment, such as cookers to melt drugs and cottons to strain impurities …

Case Studies Of The Hot Dog-Fold And Acyl-Adenylate-Forming Superfamilies: Characterizing The Importance Of Functional Divergence In Cellular Metabolism, Lucas Zimney

Chemistry and Chemical Biology ETDs

Some of the biggest contributors to cellular respiration (and cellular metabolism in general) are acyl-CoA derivatives, a subclass of biological thioesters. Known to function in a variety of pathways, the regulation of their formation and breakdown are critical, carried about by acyl-CoA synthetases and thioesterases, respectively. The work reported within this dissertation will focus on functional divergence within two enzyme superfamilies -- the hot dog-fold and acyl-adenylate-forming superfamilies — and can be broken down into two main parts. Part one will look at tracking the functional divergence within the hot dog-fold superfamily thioesterases. A highly evolved thioesterase, flK, has been …

Mining Public Databases For Discovery Of Structure And Function Within The Hotdog-Fold Thioesterase And Had Phosphatase Enzyme Families, Sarah Toews Keating

Chemistry and Chemical Biology ETDs

For my doctoral work, I have developed strategies to mine public databases for data that can be used to infer structural and functional information for the hotdog-fold and HADSF superfamilies. For the hotdog-fold superfamily, I used curated and automatically applied annotations of structure, taxonomic lineage, function, and subfamily membership from the UniProtKB, gene context and taxonomic information from the NCBI, and the results of several in-depth explorations of subfamily/function and structural class membership. Based on the distribution of the aforementioned annotations mapped onto a sequence similarity network (SSN), I applied structural assignments to sequences and/or specific function/subfamily assignments to ~143,000 …

Design, Synthesis And Evaluation Of Bivalent Inhibitors Of Trehalose-6-Phosphate Phosphatase, Chunliang Liu

Chemistry and Chemical Biology ETDs

The D-glucose disaccharide α, α-D-trehalose is synthesized by a variety of bacteria, fungi, plants and invertebrates to support cell survival by functioning as a fuel, a metabolic regulator or a protectant against environmental stress. Five different trehalose biosynthetic pathways are known to exist, one of which, the OtsA/OtsB pathway is common among pathogenic bacteria and fungi and is also found in parasitic nematodes. Previously reported otsA and otsB gene knockout (or knockdown) experiments have shown that both pathway enzymes are essential for M. tuberculosis cell growth and host colonization. RNAi gene silencing carried out in the nematode model system Caenohabditis …

The Electronic Structure Of The Pyranopterin Dithiolene Cofactor And Radical Reporters Of Excited State Interactions, Benjamin William Stein

Chemistry and Chemical Biology ETDs

Crystal structures of multiple molybdenum enzymes clearly demonstrate interesting structural distortions involving the pyranopterin dithiolene. These distortions can be correlated with pyranopterin oxidation state through the use of DFT geometry optimized structures of the possible oxidation states, and these are correlated with enzyme family. The potential role of the pyranopterin dithiolene in electron transfer in the varied enzyme familes has been explored through the use of non-equilibrium Green's function (NEGF) electron transport calculations. These calculations demonstrate clear differences in electron transport behavior as a function of pyranopterin oxidation state. The Jahn-Teller effect can strongly impact the geometric and electronic structures …

Electrochemical Investigation Of Homogenous Species At An Electrode Interface, Christopher Larsen Iii

Chemistry and Chemical Biology ETDs

CO2 reduction is a pressing problem worldwide, and one obstacle in the electrochemical conversion of CO2 to more useful C1 products such as methanol and formic acid is the kinetic barrier known as overpotential. The overpotential of rearranging the nuclei in CO2 to accommodate electron transfer can be lowered by pre-bending the CO2 molecule in an adduct-mediated complex. The work presented in Part I utilizes a combination of hard and soft donors on pincer-like ligands to effect the bending of CO2 prior to electrochemical reduction. A large majority of the work consists of using Group 4 metallocenes, but Chapter 3 …

Spectroscopic And Computational Studies Of Molybdenum Enzymes And Models, Chao Dong

Chemistry and Chemical Biology ETDs

In this dissertation spectroscopic methods such as electronic absorption (EAS), resonance Raman (rRaman), electron paramagnetic resonance (EPR), and MCD spectroscopies have been used in combination with DFT calculations for the interpretation of experimental results. These methods have been used to investigate the molybdenum coordination environment in enzymes and model complexes. Xanthine oxidase (XO), one of the canonical molybdenum enzyme families, hydroxylizes heterocyclic substrates by inserting an oxygen atom from molybdenum-activated water into a substrate C-H bond. This generates reducing equivalents that pass through two iron sulfur clusters and then to FAD, where oxidation of the FAD takes place. In this …

Study Of Novel Synthetic Methodologies For Indolyl Derivatives And Beta-Fluoroenals, Xiaobei Chen

Chemistry and Chemical Biology ETDs

One of the central goals in modern organic synthesis is to develop efficient synthetic strategies for the preparation and study of complex molecules possessing interesting structural, biological, and physical properties. Toward this end, my Ph. D. work focuses on the development of novel synthetic methodologies for the facile construction of synthetically and biologically significant molecular architectures. The tert-prenylated indoles and indolines are widely present in a large collection of natural products and biologically active compounds. Although significant efforts have been made on the development of efficient methods to prepare these intriguing molecular architectures, few methods have been explored to introduce …

K-Theory And Pseudospectra For Topological Insulators [Dataset], Terry A. Loring

Math and Statistics Datasets

We derive formulas and algorithms for Kitaev's invariants in the periodic table for topological insulators and superconductors for finite disordered systems on lattices with boundaries. We find that K-theory arises as an obstruction to perturbing approximately compatible observables into compatible observables. We derive formulas in all symmetry classes up to dimension two, and in one symmetry class in dimension three, that can be computed with sparse matrix algorithms. We present algorithms in two symmetry classes in 2D and one in 3D and provide illustrative studies regarding how these algorithms can detect the scaling properties of phase transitions.

Acknowledgment Of Supporters, Utton Center, University Of New Mexico - School Of Law

Water Matters!

List of supporters.

Mod Planes: A New Dimension To Modulo Theory, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book for the first time authors study mod planes using modulo intervals [0, m); 2 ≤ m ≤ ∞. These planes unlike the real plane have only one quadrant so the study is carried out in a compact space but infinite in dimension. We have given seven mod planes viz real mod planes (mod real plane) finite complex mod plane, neutrosophic mod plane, fuzzy mod plane, (or mod fuzzy plane), mod dual number plane, mod special dual like number plane and mod special quasi dual number plane. These mod planes unlike real plane or complex plane or neutrosophic …

Neutrosophic Graphs: A New Dimension To Graph Theory, Florentin Smarandache, Wb. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors for the first time have made a through study of neutrosophic graphs. This study reveals that these neutrosophic graphs give a new dimension to graph theory. The important feature of this book is it contains over 200 neutrosophic graphs to provide better understanding of this concepts. Further these graphs happen to behave in a unique way inmost cases, for even the edge colouring problem is different from the classical one. Several directions and dimensions in graph theory are obtained from this study. Finally certainly these new notions of neutrosophic graphs in general and in particular the …

Special Type Of Topological Spaces Using [0, N), Florentin Smarandache, W.B Vasantha Kandasamy

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors for the first time introduce the notion of special type of topological spaces using the interval [0, n). They are very different from the usual topological spaces. Algebraic structure using the interval [0, n) have been systemically dealt by the authors. Now using those algebraic structures in this book authors introduce the notion of special type of topological spaces. Using the super subset interval semigroup special type of super interval topological spaces are built. Several interesting results in this direction are obtained. Next six types of topological spaces using subset interval pseudo ring semiring of type …

Mod Functions: A New Approach To Function Theory, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book the notion of MOD functions are defined on MOD planes. This new concept of MOD functions behaves in a very different way. Even very simple functions like y = nx has several zeros in MOD planes where as they are nice single line graphs with only (0, 0) as the only zero. Further polynomials in MOD planes do not in general follows the usual or classical laws of differentiation or integration. Even finding roots of MOD polynomials happens to be very difficult as they do not follow the fundamental theorem of algebra, viz a nth degree polynomial …

Sampling Strategies For Finite Population Using Auxiliary Information, Florentin Smarandache, Rajesh Singh

Branch Mathematics and Statistics Faculty and Staff Publications

The present book aims to present some improved estimators using auxiliary and attribute information in case of simple random sampling and stratified random sampling and in some cases when non-response is present. This volume is a collection of five papers, written by seven co-authors (listed in the order of the papers): Sachin Malik, Rajesh Singh, Florentin Smarandache, B. B. Khare, P. S. Jha, Usha Srivastava and Habib Ur. Rehman. The first and the second papers deal with the problem of estimating the finite population mean when some information on two auxiliary attributes are available. In the third paper, problems related …

Uncertainty Communication Solution In Neutrosophic Key, Florentin Smarandache, Bianca Tedorescu, Mirela Teodorescu

Branch Mathematics and Statistics Faculty and Staff Publications

This study is the first step of a research that points out the solving of uncertainties in process analysis. The research is based on Neutrosophy Theory (Smarandache, 1995), a new concept of states treatment with a generous applicability to sciences, like artificial intelligence (Vladareanu et al, 2014).

N-Valued Interval Neutrosophic Sets And Their Application In Medical Diagnosis, Said Broumi, Irfan Deli, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper a new concept is called n-valued interval neutrosophic sets is given. The basic operations are introduced on n-valued interval neutrosophic sets such as; union, intersection, addition, multiplication, scalar multiplication, scalar division, truthfavorite and false-favorite. Then, some distances between n-valued interval neutrosophic sets (NVINS) are proposed. Also, we propose an efficient approach for group multi-criteria decision making based on n-valued interval neutrosophic sets. An application of n-valued interval neutrosophic sets in medical diagnosis problem is given.

(T, I, F)-Neutrosophic Structures, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper we introduce for the first time a new type of structures, called (T, I, F)-Neutrosophic Structures, presented from a neutrosophic logic perspective, and we show particular cases of such structures in geometry and in algebra. In any field of knowledge, each structure is composed from two parts: a space, and a set of axioms (or laws) acting (governing) on it. If the space, or at least one of its axioms (laws), has some indeterminacy, that structure is a (T, I, F)-Neutrosophic Structure.

Neutrosophic Axiomatic System, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper, we introduce for the first time the notions of Neutrosophic Axiom, Neutrosophic Axiomatic System, Neutrosophic Deducibility and Neutrosophic Inference, Neutrosophic Proof, Neutrosophic Tautologies, Neutrosophic Quantifiers, Neutrosophic Propositional Logic, Neutrosophic Axiomatic Space, Degree of Contradiction (Dissimilarity) of Two Neutrosophic Axioms, and Neutrosophic Model. A class of neutrosophic implications is also introduced. A comparison between these innovatory neutrosophic notions and their corresponding classical notions is made. Then, three concrete examples of neutrosophic axiomatic systems, describing the same neutrosophic geometrical model, are presented at the end of the paper.

Symbolic Neutrosophic Theory, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Symbolic (or Literal) Neutrosophic Theory is referring to the use of abstract symbols (i.e. the letters T, I, F, or their refined indexed letters T_j, I_k, F_l) in neutrosophics.

In the first chapter we extend the dialectical triad thesis-antithesis-synthesis (dynamics of A and antiA, to get a synthesis) to the neutrosophic tetrad thesis-antithesis-neutrothesis-neutrosynthesis (dynamics of A, antiA, and neutA, in order to get a neutrosynthesis).

In the second chapter we introduce the neutrosophic system and neutrosophic dynamic system. A neutrosophic system is a quasi- or –classical system, in the sense that the neutrosophic …

Sustainable Livelihood Systems In Nepal: Principles, Practices And Prospects, Ambika P. Adhikari, Govinda P. Dahal, Ishara Mahat, Bishwa Regmi, Kalidas Subedi, Bharat Shrestha (Eds.)

Himalayan Research Papers Archive

No abstract provided.

Algebraic Problems And Exercises For High School, Florentin Smarandache, Ion Goian, Raisa Grigor, Vasila Marin

Branch Mathematics and Statistics Faculty and Staff Publications

In this book, you will find algebraic exercises and problems, grouped by chapters, intended for higher grades in high schools or middle schools of general education. Its purpose is to facilitate training in mathematics for students in all high school categories, but can be equally helpful in a standalone work. The book can also be used as an extracurricular source, as the reader shall find enclosed important theorems and formulas, standard definitions and notions that are not always included in school textbooks.

Infinite Quaternion Pseudo Rings Using [0, N), Florentin Smarandache, W.B. Vasantha Kandasamy

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors study the properties of finite real quaternion ring which was introduced in [2000]. Here a complete study of these finite quaternion rings are made. Also polynomial quaternion rings are defined, they happen to behave in a very different way. In the first place the fundamental theorem of algebra, “a nth degree polynomial has n and only n roots”, n is untrue in case of polynomial in polynomial quaternion rings in general. Further the very concept of derivative and integrals of these polynomials are untrue. Finally interval pseudo quaternion rings also behave in an erratic way. Not …

Neutrosophic Crisp Set Theory, Florentin Smarandache, A.A. Salama

Branch Mathematics and Statistics Faculty and Staff Publications

Since the world is full of indeterminacy, the Neutrosophics found their place into contemporary research. We now introduce for the first time the notions of Neutrosophic Crisp Sets and Neutrosophic Topology on Crisp Sets. We develop the 2012 notion of Neutrosophic Topological Spaces and give many practical examples. Neutrosophic Science means development and applications of Neutrosophic Logic, Set, Measure, Integral, Probability etc., and their applications in any field. It is possible to define the neutrosophic measure and consequently the neutrosophic integral and neutrosophic probability in many ways, because there are various types of indeterminacies, depending on the problem we need …

Algebraic Structures On Mod Planes, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

Study of MOD planes happens to a very recent one. Authors have studied several properties of MOD real planes Rn(m); 2 ≤ m ≤ ∞. In fact unlike the real plane R × R which is unique MOD real planes are infinite in number. Likewise MOD complex planes Cn(m); 2 ≤ m ≤ ∞, are infinitely many. The MOD neutrosophic planes RnI(m); 2 ≤ m ≤ ∞ are infinite in number where as we have only one neutrosophic plane R(I) = 〈R ∪ I〉 = {a + bI | I2 = I; a, b ∈ R}. Further three other new …

Natural Neutrosophic Numbers And Mod Neutrosophic Numbers, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors answer the question proposed by Florentin Smarandache “Does there exist neutrosophic numbers which are such that they take values differently and behave differently from I; the indeterminate?”. We have constructed a class of natural neutrosophic numbers m 0I , m xI , m yI , m zI where m 0I × m 0I = m 0I , m xI × m xI = m xI and m yI × m yI = m yI and m yI × m xI = m 0I and m zI × m zI = m 0I . Here take m …

Mod Pseudo Linear Algebras, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors for the first time elaborately study the notion of MOD vector spaces and MOD pseudo linear algebras. This study is new, innovative and leaves several open conjectures. In the first place as distributive law is not true we can define only MOD pseudo linear algebras. Secondly most of the classical theorems true in case of linear algebras are not true in case of MOD pseudo linear algebras. Finding even eigen values and eigen vectors happens to be a challenging problem. Further the notion of multidimensional MOD pseudo linear algebras are defined using the notion of MOD …

Multidimensional Mod Planes, Florentin Smarandache, W.B. Vasantha Kandasamy, K. Ilanthenral

Branch Mathematics and Statistics Faculty and Staff Publications

In this book authors name the interval [0, m); 2 ≤ m ≤ ∞ as mod interval. We have studied several properties about them but only here on wards in this book and forthcoming books the interval [0, m) will be termed as the mod real interval, [0, m)I as mod neutrosophic interval, [0,m)g; g2 = 0 as mod dual number interval, [0, m)h; h2 = h as mod special dual like number interval and [0, m)k, k2 = (m − 1) k as mod special quasi dual number interval. However there is only one real interval (∞, ∞) but …

Fuzzy Abel Grassmann Groupoids, Florentin Smarandache, Madad Khan, Tariq Aziz

Branch Mathematics and Statistics Faculty and Staff Publications

Usually the models of real world problems in almost all disciplines like engineering, medical sciences, mathematics, physics, computer science, management sciences, operations research and articial intelligence are mostly full of complexities and consist of several types of uncertainties while dealing them in several occasion. To overcome these di¢ culties of uncertainties, many theories have been developed such as rough sets theory, probability theory, fuzzy sets theory, theory of vague sets, theory of soft ideals and the theory of intuitionistic fuzzy sets, theory of neutrosophic sets, Dezert-Smarandache Theory (DSmT), etc. Zadeh introduced the degree of membership/truth (t) in 1965 and dened …

Theory Of Abel Grassmann's Groupoids, Florentin Smarandache, Madad Khan

Branch Mathematics and Statistics Faculty and Staff Publications

It is common knowledge that common models with their limited boundaries of truth and falsehood are not su¢ cient to detect the reality so there is a need to discover other systems which are able to address the daily life problems. In every branch of science problems arise which abound with uncertainties and impaction. Some of these problems are related to human life, some others are subjective while others are objective and classical methods are not su¢ cient to solve such problems because they can not handle various ambiguities involved. To overcome this problem, Zadeh [67] introduced the concept of …