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Mean-Field Boolean Network Model Of A Signal Transduction Network, Naomi Kochi, Mihaela Teodora Matache
Mean-Field Boolean Network Model Of A Signal Transduction Network, Naomi Kochi, Mihaela Teodora Matache
Mathematics Faculty Publications
In this paper we provide a mean-field Boolean network model for a signal transduction network of a generic fibroblast cell. The network consists of several main signaling pathways, including the receptor tyrosine kinase, the G-protein coupled receptor, and the Integrin signaling pathway. The network consists of 130 nodes, each representing a signaling molecule (mainly proteins). Nodes are governed by Boolean dynamics including canalizing functions as well as totalistic Boolean functions that depend only on the overall fraction of active nodes. We categorize the Boolean functions into several different classes. Using a mean-field approach we generate a mathematical formula for the …