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Full-Text Articles in Physical Sciences and Mathematics

Spectrophotometric And Colorimetic Methodology To Detect And Quantify Hydrazide Based Chemotherapeutic Drugs, Ronald Bartzatt Feb 2010

Spectrophotometric And Colorimetic Methodology To Detect And Quantify Hydrazide Based Chemotherapeutic Drugs, Ronald Bartzatt

Chemistry Faculty Publications

Pharmaceuticals having the hydrazide functional group are an important division within anti-tuberculosis, anti-parasitic, anti-cancer, and anti-radiation chemotherapeutics. This work presents a colorimetric methodology to detect and quantify hydrazide based pharmaceuticals. Processes for rapid spot test, qualitative colorimetric assay, and spectrophotometric quantitative assay are presented. The reagent 2,6-dichloroquinon-4-chloroimine (Gibb's reagent) is utilized to accomplish the various analytical objectives. The rapid spot test and qualitative colorimetric assay enables a detection of hydrazide drugs to a level of 0.0037 grams per milliliter. Quantitative spectrophotometric detection of hydrazide drugs is sensitive to a level of 128.2 micrograms permilliliter. The molar absorptivity () is calculated …


A Parallel Non-Alignment Based Approach To Efficient Sequence Comparison Using Longest Common Subsequences, Sanjukta Bhowmick, Mohammad Shafiullah, H. Rai, Dhundy Raj Bastola Jan 2010

A Parallel Non-Alignment Based Approach To Efficient Sequence Comparison Using Longest Common Subsequences, Sanjukta Bhowmick, Mohammad Shafiullah, H. Rai, Dhundy Raj Bastola

Chemistry Faculty Publications

Biological sequence comparison programs have revolutionized the practice of biochemistry, and molecular and evolutionary biology. Pairwise comparison of genomic sequences is a popular method of choice for analyzing genetic sequence data. However the quality of results from most sequence comparison methods are significantly affected by small perturbations in the data and furthermore, there is a dearth of computational tools to compare sequences beyond a certain length. In this paper, we describe a parallel algorithm for comparing genetic sequences using an alignment free-method based on computing the Longest Common Subsequence (LCS) between genetic sequences. We validate the quality of our results …


What Is Wrong With Water Barometers?, Dan Sullivan, Robert W. Smith, E. J. Kemnitz, Kevin Barton, Robert M. Graham, Raymond A. Guenther, Larry Webber Jan 2010

What Is Wrong With Water Barometers?, Dan Sullivan, Robert W. Smith, E. J. Kemnitz, Kevin Barton, Robert M. Graham, Raymond A. Guenther, Larry Webber

Chemistry Faculty Publications

Every student who studies atmospheric pressure in physics or chemistry learns the principles behind the construction of barometers. Cistern barometers, such as those found in most laboratories, consist of a long glass tube containing an inverted column of liquid having an open end in a cistern of the liquid. Students learn that the column of liquid is supported by air pressure and is equal in weight to a column of air of the same diameter.