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University of Nebraska - Lincoln
Department of Chemistry: Dissertations, Theses, and Student Research
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Synthesis And Applications Of Cyclobutenes, Benjamin Enns
Synthesis And Applications Of Cyclobutenes, Benjamin Enns
Department of Chemistry: Dissertations, Theses, and Student Research
Our group is interested in cyclobutene analogs of fatty acids as reactive coatings, potential antibiotics, and as a new class of bioconjugate linkers. A convenient synthesis of this class of molecules was previously reported from our lab. However, ammonia, a key reagent in the earlier route, was recently reclassified as a highly corrosive gas requiring highly specialized equipment for storage and handling. The goal of this research was to find a convenient synthesis for the formation of cyclobutene that did not involve the use of ammonia. The other part of this thesis describes the preparation of a short chain cyclobutene …