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Full-Text Articles in Physical Sciences and Mathematics
Engineered Nanoparticles For Detection And Treatment Of Bacteria And Biofilms, Xiaoning Li
Engineered Nanoparticles For Detection And Treatment Of Bacteria And Biofilms, Xiaoning Li
Doctoral Dissertations
Rapid and sensitive detection and identification of bacteria woud control and prevent bacterial infection and disease, enhancing the likelihood of early diagnosis and treatment. Especially developing effective biosensor for identification of bacteria species involved in formation of biofilms, which cause chronic and persistent diseases, would promote diagnostic and therapeutic efficiency. Conventional detection methods are limited by sensitivity and required time. First part of my research has been focused on developing a rapid, simple, and sensitive biosensor aiming at portable device application for detection of bacteria in water samples. This sensor is able to detect bacteria at low concentration and generate …
Modification Of Gold Nanoparticles For Sers Application In Emulsion And Lipid Systems, Michael J. Driver
Modification Of Gold Nanoparticles For Sers Application In Emulsion And Lipid Systems, Michael J. Driver
Masters Theses
Gold nanoparticles produced using the Turkevich method were able to have their hydrophobicity modified using octanethiol in a novel method for SERS application. Both amphiliphic GNPs and hydrophobic GNPs were produced and differentiated by Raman signals. The amphiliphic GNPs were able to enhance the SERS signals of the protein emulsifier in the emulsion in situ and the hydrophobic GNPs were able to enhance the SERS signals from canola oil. Further purification of the hydrophobic GNPs proved to have higher enhancement and sensitivity, but still poor consistency which is typical of SERS. Monitoring lipid oxidation using Raman and SERS using alternative …
Mass Spectrometric Characterization And Imaging Of Nanoparticles In Biological Samples, Bo Yan
Mass Spectrometric Characterization And Imaging Of Nanoparticles In Biological Samples, Bo Yan
Doctoral Dissertations
Nanoparticles (NPs) are being investigated widely for use in biomedical applications such as imaging, drug delivery, and cancer therapy due to their small size and readily tunable properties. The ability to accurately characterize NPs and monitor their spatial distributions is highly desirable for effective use of NPs and evaluation of their potential adverse environmental, health, and safety effects. In this dissertation, a simple, fast, and sensitive method based on laser desorption/ionization mass spectrometry (LDI-MS) to characterize and track NPs in biological systems has been developed. This method is especially well suited for characterizing core-shell structured NPs, such as quantum dots …