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Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Nanoparticle Building Blocks For Functional Structures, Youngdo Jeong
Nanoparticle Building Blocks For Functional Structures, Youngdo Jeong
Doctoral Dissertations
A major goal in material science is achieving a desired function using structures fabricated with designed building blocks. Advanced synthetic and self-assembly techniques allow various nanomaterials to become promising building blocks, providing the control of the interaction between building blocks. The unique properties of nanomaterials can be transferred to structured systems. Among nanomaterials, inorganic nanoparticles such as gold nanoparticles (AuNPs), magnetic particles, and quantum dots (QDs) provide useful physical properties stemming from their inorganic core, large surface areas, and oriented surface functionalities. My research has focused on fabricating functional systems using gold nanoparticles (AuNPs), manipulating the interaction between AuNPs, bio-entities, …
Functional Phosphorylcholine Polymers: Prodrugs And Biomaterials, Samantha B.M. Page
Functional Phosphorylcholine Polymers: Prodrugs And Biomaterials, Samantha B.M. Page
Doctoral Dissertations
This thesis describes the synthesis and applications of multifunctional, hydrophilic polymers consisting of a methacrylate backbone and zwitterionic phosphorylcholine (PC) pendent groups, prepared by free radical polymerization of the zwitterionic monomer, 2-methacryloyloxyethyl phosphorylcholine (MPC). Advances in polymer chemistry, applied to PC polymers, allowed for the preparation of well-defined structures with controlled molecular weight, narrow polydispersity, and facile incorporation of functional comonomers, giving breadth to the range of materials accessible for different applications. Built-in functionality included fluorophores and reactive groups for post-polymerization transformations, such as drug conjugation or cross-linking. The ability to form well-defined structures based on the polyMPC backbone is …
Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego Amado Torres
Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego Amado Torres
Doctoral Dissertations
Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of …