Physical Sciences and Mathematics Commons^™

Application Of The Two-Variable Model To Simulate A Multisensory Reaction-Time Task, Rebecca Brady, John Butler

Academic Posters Collection

To navigate the world in an efficient manner, the brain seamlessly integrates signals received across multiple sensory modalities. Behavioral studies have suggested that multisensory processing is a winner-take-all sensory response mechanism to some optimal combination of sensory signals. In addition, multiple sensory cues are not always beneficial with some studies showing maladaptive multisensory processing as an identifier of older adults prone to falls from age matched healthy controls.

A stalwart of modelling sensory decision-making is the work by (Wong &Wang, 2006) but to date almost all of this research has been focused on unisensory tasks. We extend the reduced two-variable …

Direct Immunoassays And Their Performance: Theoretical Modelling Of The Effects Of Antibody Orientation And Associated Kinetics, Dana Mackey, Eilis Kelly, Robert Nooney, Richard O'Kennedy

Articles

The orientation and activity of antibodies immobilized on solid surfaces are of direct relevance to many immunosensing applications. We therefore investigate a mathematical model which estimates the fraction of antibodies which are available for reaction in a randomly adsorbed sample. Numerical simulations are presented which highlight the separate effects of antibody orientation, accessibility and loss of binding ability on the amount of captured antigen. The assay response can then be expressed as a function of total antibody density and used for optimizing the surface coverage strategy under various conditions.