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Full-Text Articles in Physical Sciences and Mathematics
The Synthesis And Anticonvulsant Activity Of 1-Substituted-7-Methoxy-1,2,4-Triazolo [4,~3-A]Quinoline, Li-Ping Guan, Xian-Yu Sun, Guan-Rong Tian, Kyu-Yun Chai, Zhe-Shan Quan
The Synthesis And Anticonvulsant Activity Of 1-Substituted-7-Methoxy-1,2,4-Triazolo [4,~3-A]Quinoline, Li-Ping Guan, Xian-Yu Sun, Guan-Rong Tian, Kyu-Yun Chai, Zhe-Shan Quan
Turkish Journal of Chemistry
A new series of 1-substituted-7-methoxy-5-phenyl-1,2,4-triazolo [4,3-a]quinolines were synthesized using ethyl-3-oxo-3-phenylpropanoate and 4-methoxybenzenamine as the starting material. Their anticonvulsant activity was evaluated by the maximal electroshock (MES) test and 7-methoxy-5-phenyl-1,2,4-triazolo[4,3-a]quinoline (4a) was identified as the most potent compound, with an ED_{50} value of 9.2 mg kg^{-1}, which is comparable to the reference drug phenytoin (ED_{50} = 9.9 mg kg^{-1}). To explore the possible mechanism of its anticonvulsant activity, compound 4a was tested with the rotarod neurotoxicity test, pentylenetetrazole (sc-PTZ) test, and isoniazid test. Compound 4a had a higher protective index (PI = TD_{50}/ED_{50}) value (16.6) than phenytoin (PI = 7.0), and …
Synthesis And Characterizations Of Some New 4h-1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şule Ceylan, Deni̇z Şahi̇n
Synthesis And Characterizations Of Some New 4h-1,2,4-Triazole Derivatives, Nesli̇han Demi̇rbaş, Ahmet Demi̇rbaş, Şule Ceylan, Deni̇z Şahi̇n
Turkish Journal of Chemistry
3-[(5-Amino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (2a,b) were obtained from the reaction of 3-cyanomethyl-5-alkyl-4-ethoxycarbonylamino-4H-1,2,4-triazoles (1a,b) with thiosemicarbazide in the presence of trifluoroacetic acid. The treatment of the obtained compounds (2a,b) with acetic anhydride for 1 h afforded 3-[(5-acetylamino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (3a,b). The synthesis of 4-ethoxycarbonylamino-3-[(2,3-dihydro-1,3-benzoxazol-2-yl)methyl]-5-(4-methylbenzyl)-4H-1,2,4-triazole (4) was performed by the treatment of 3-[(5-acetylamino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-(4-methylbenzyl)-4H-1,2,4-triazole (3a) with o-aminophenol under nitrogen atmosphere for 50 h. The reaction of compounds 1a,b with salicylaldehyde in the presence of sodium ethoxide yielded 2-{4-[(ethoxycarbonyl)amino]-5-alkyl-4H-1,2,4-triazol-3-yl}-3-(2-hydroxyphenyl)-acrylonitriles (5a,b). The acetylations of compounds 5a,b with acetic anhydride for 5 h resulted in the formation of 2-{4-[acetyl(ethoxycarbonyl)amino]-5-alkyl-4H-1,2,4-triazol-3-yl}-3-[2-(acetyloxy)phenyl]-acrylic acids (6a,b). On the other hand, the treatment of compounds 5a,b with …
Synthesis And Characterization Of New Tridentate Iminooxime Ligands And Their Co(Iii) Complexes, Hasene Mutlu, Gazi̇ İrez
Synthesis And Characterization Of New Tridentate Iminooxime Ligands And Their Co(Iii) Complexes, Hasene Mutlu, Gazi̇ İrez
Turkish Journal of Chemistry
In this study, (hydroxyimino)(2-phenyl(1,2,3,4-tetrahydroquinazolin- 2-yl))methane (H_2L^1) and (hydroxyimino)(2-(2-thienyl)(1,2,3,4- tetrahydroquinazolin-2-yl))methane (H_2L^2) were synthesized by the condensation of 2-(hydroxyimino)-1-phenylethan-1-one (INAP) and 2-(hydroxyimino)-1-(2-thienyl)ethan-1-one (INAT) with 2-aminobenzylamine (2-ABA). Complexes of these ligands with Co^{3+} were prepared with a metal:ligand ratio of 1:2. The ligands and their complexes were elucidated on the basis of elemental analyses, AAS, FT-IR, ^1H- and ^{13}C-NMR spectra, mass spectra, magnetic susceptibility measurements, and molar conductivity.
Synthesis, X-Ray Structure, And Bioassay Of Newly Synthesized Trimethyltin(Iv) 2,3-Methylenedioxy Benzoate, Mukhtiar Hussain, Muhammad Hanif, Saqib Ali, Saira Shahzadi, Helen S. Evans
Synthesis, X-Ray Structure, And Bioassay Of Newly Synthesized Trimethyltin(Iv) 2,3-Methylenedioxy Benzoate, Mukhtiar Hussain, Muhammad Hanif, Saqib Ali, Saira Shahzadi, Helen S. Evans
Turkish Journal of Chemistry
Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized and characterized in solution state by multinuclear NMR (^1H, ^{13}C and ^{119}Sn) using the noncoordinating solvent and also in solid sate by FTIR, mass spectrometry, and X-ray crystallography. Spectroscopic data have shown that methylenedioxy moiety has not coordinated with tin atom; instead, the coordination site is a -COO group, which is proved by spectral and XRD data. The solid state structure shows the trigonal bipyramidal geometry with a space group P2_1/c. This compound was tested for its in vitro antitumor activity.
Preparation, Characterization, And Potentiometric Titrations Of Some New Di-[3-(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)-Azomethinphenyl] Isophthalate/Terephthalate Derivatives, Haydar Yüksek, Özlem Gürsoy Kol
Preparation, Characterization, And Potentiometric Titrations Of Some New Di-[3-(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)-Azomethinphenyl] Isophthalate/Terephthalate Derivatives, Haydar Yüksek, Özlem Gürsoy Kol
Turkish Journal of Chemistry
3-Alkyl(Aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) reacted with di-(3-formylphenyl) isophthalate (3) and di-(3-formylphenyl) terephthalate (6) to afford the corresponding 6 novel di-[3-(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)- azomethinphenyl] isophthalates (4) and 6 novel di-[3-(3-alkyl/aryl-4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl] terephthalates (7), respectively. The acetylation reactions of compounds 4 and 7 were investigated, and 5 and 8 type compounds were obtained, respectively. The new compounds synthesized were characterized by using IR, ^1H-NMR, ^{13}C-NMR, and UV spectral data together with elemental analysis. In addition, to investigate the effects of solvents and molecular structure upon acidity, compounds 4 and 7 were titrated potentiometrically with tetrabutylammonium hydroxide in 5 non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, N,N-dimethylformamide, acetone, …
Compounds Isolated From Tannacetum Polycephalum, . Azizuddin, Muhammad Iqbal Choudhary
Compounds Isolated From Tannacetum Polycephalum, . Azizuddin, Muhammad Iqbal Choudhary
Turkish Journal of Chemistry
Several known secondary metabolites, namely lupeol (1), \beta-sitosterol (2), stigmasterol (3), and 2,6-dimethoxy-4-hydroxy acetophenone (4) were isolated from a folkloric medicinal plant, Tannacetum polycephalum. The structures of these compounds were elucidated on the basis of various spectroscopic methods.