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Full-Text Articles in Physical Sciences and Mathematics
Color Image Noise Reduction With The Total Variation Model And Proximity Operators, Aaron Katchen
Color Image Noise Reduction With The Total Variation Model And Proximity Operators, Aaron Katchen
Honors Capstone Projects - All
The following paper discusses how efficient and effective color image noise reduction may be achieved through the use of mathematic numerical analysis. Digital image noise is a longstanding problem for which efficient and effective solutions are critical to the advancement of the field of digital imaging. Micchelli-Shen-Xu [3] used the Total Variation Model in conjunction with proximity operators to propose a set of algorithms to effectively and efficiently solve for noisy grayscale images. They proposed the use of the proximity operator in anisotropic and isotropic total variation in fixed point algorithms. The following paper will discuss their algorithms as well …
Nonamphiphilic Modification Of The Self-Assembly Behavior Of Surfactants And The Potential For Bolaamphiphile-Based Vesicle Formation In The Presence Of 5’Disodium Cromoglycate, Nemal S. Gobalasingham
Nonamphiphilic Modification Of The Self-Assembly Behavior Of Surfactants And The Potential For Bolaamphiphile-Based Vesicle Formation In The Presence Of 5’Disodium Cromoglycate, Nemal S. Gobalasingham
Honors Capstone Projects - All
Emulsion systems stabilized by surfactants have historically been driven by the separation of hydrophobic oils from water, essentially creating surfactant micelles. As surfactant molecules aggregate around the oil, they self-assemble in such a way that the hydrophobic chains of the surfactants face inward toward the oil while the hydrophilic, or water-loving, “head” of the surfactant face outward toward the water medium. The emergence of water-in-water emulsions consisting of droplets of a water-solvated biocompatible liquid crystals, disodium cromoglycate (5’DSCG), with polymers has unlocked the potential for modifying the self-assembly behavior of surfactants. We report here on the capacity of 5’DSCG to …
Synthetic Dosage Lethality Screen With Actin Cytoskeleton In Yeast, Jessica Cho
Synthetic Dosage Lethality Screen With Actin Cytoskeleton In Yeast, Jessica Cho
Honors Capstone Projects - All
The actin cytoskeleton is a vitally important organizing structure found in the cytoplasm of our cells. It contributes to essential cell functions from growth and cell division, development, signal transduction, adaptation, to gene expression. Interest in how regulation of the actin cytoskeleton---due to actin cytoskeleton's importance to cell function-may contribute to diverse human disease states such as the rampant cell division and metastasis that occurs in cancerous tissues. It has been further elucidated that many human genetic disorders are the result of complex haploinsufficiencies (CHI) and/or altered gene dosages at multiple loci. By reviewing a large number of potential Synthetic …
Germline Cyst Formation And Development In Zebrafish, Tess Cherlin
Germline Cyst Formation And Development In Zebrafish, Tess Cherlin
Honors Capstone Projects - All
In developing pre-natal mice, germline cysts are clusters or packages of cells consisting of individual oocytes. They are formed after the primordial germ cells move to the ovary during embryogenesis. The primordial germ cells divide, but do not completely separate. The cells within the cysts are linked by intercellular bridges, which end up breaking down leading to the formation of primordial follicles. The primordial follicles are oocytes surrounded by somatic cells called granulosa cells. Only one third of the original oocytes survive cyst breakdown and become the eggs that will be used by the mouse for her reproduction. This developmental …
A Biosynthetic Membrane-Anchor/Protein System Based On A Genetically Encoded "Aldehyde Tag", Chaojie Zhen
A Biosynthetic Membrane-Anchor/Protein System Based On A Genetically Encoded "Aldehyde Tag", Chaojie Zhen
Honors Capstone Projects - All
Lipid membranes or bilayers serve as barriers for the cell and its organelles. A distinguishing feature of cellular function is the ability to monitor and process the biochemical information between the cells’ intra and extracellular environments in order to maintain the homeostatic reactions that are essential to life. Surface membrane proteins play a key role in mediating this information exchange by functionalizing the bilayer. As a result of their importance in living systems, proteins are integrated into biomimetic membrane systems to replicate their natural functions in biomedical technologies. Current protein integration methods are limited by the selection of commercially available …
Exploring The Potential For B12-Based Oral Vaccine Delivery; Cubilin Mediated Uptake Of B12-Conjugate Systems Greater Than 160 Kda, Teresa Soldner
Exploring The Potential For B12-Based Oral Vaccine Delivery; Cubilin Mediated Uptake Of B12-Conjugate Systems Greater Than 160 Kda, Teresa Soldner
Honors Capstone Projects - All
This project aimed to create a novel oral tetanus vaccine by exploiting the B12 uptake pathway. While many linkers were attempted, the only successful complex was created using CDT coupling. After synthesis, purification (with some difficulty), and characterization, tests were done in vitro and in vivo. These supported the conclusion that while the complex was being successfully taken up by the cell, the complex was not created a strong enough immune response for a positive titer. On a second note, simply the uptake of B12-TT is remarkable because it is the largest molecule that has been …
Quantum Dot Biofunctionalization, Nathaniel J. Miska
Quantum Dot Biofunctionalization, Nathaniel J. Miska
Honors Capstone Projects - All
We have shown the efficacy of Quantum Dots (qdots), nano-scale fluorescent particles made of semi-conductive material, as versatile biologically functional research tools. This functionality depends upon a series of chemical transformations that produce stable, aqueous, biomolecule-bound qdots with high quantum yield. We utilize the metal binding and chelating properties of the amino acid histidine to displace hydrophobic surface ligands and to phase-transfer qdots from organic to aqueous media. The intermediate binding strength of histidine to qdot surface facilitates its exchange with a variety of strongly binding thiolated biomolecules. Ligand profiles are subsequently characterized via FTIR, NMR, and gel electrophoresis. Negatively-charged …