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Full-Text Articles in Physical Sciences and Mathematics
Structural Analysis Of The Hot Spots In The Binding Between H1n1 Ha And The 2di Antibody: Do Mutations Of H1n1 From 1918 To 2009 Affect Much On This Binding?, Qian Liu, Steven C. H. Hoi, Chinh T. T. Su, Zhenhua Li, Chee-Keong Kwoh, Limsoon Wong, Jinyan Li
Structural Analysis Of The Hot Spots In The Binding Between H1n1 Ha And The 2di Antibody: Do Mutations Of H1n1 From 1918 To 2009 Affect Much On This Binding?, Qian Liu, Steven C. H. Hoi, Chinh T. T. Su, Zhenhua Li, Chee-Keong Kwoh, Limsoon Wong, Jinyan Li
Research Collection School Of Computing and Information Systems
Worldwide and substantial mortality caused by the 2009 H1N1 influenza A has stimulated a new surge of research on H1N1 viruses. An epitope conservation has been learned in the HA1 protein that allows antibodies to cross-neutralize both 1918 and 2009 H1N1. However, few works have thoroughly studied the binding hot spots in those two antigen–antibody interfaces which are responsible for the antibody cross-neutralization. We apply predictive methods to identify binding hot spots at the epitope sites of the HA1 proteins and at the paratope sites of the 2D1 antibody. We find that the six mutations at the HA1's epitope from …
Beespace Navigator: Exploratory Analysis Of Gene Function Using Semantic Indexing Of Biological Literature, Moushumi Sen Sarma, David Arcoleo, Radhika S. Khetani, Brant Chee, Xu Ling, Xin He, Jing Jiang, Qiaozhu Mei, Chengxiang Zhai, Bruce Schatz
Beespace Navigator: Exploratory Analysis Of Gene Function Using Semantic Indexing Of Biological Literature, Moushumi Sen Sarma, David Arcoleo, Radhika S. Khetani, Brant Chee, Xu Ling, Xin He, Jing Jiang, Qiaozhu Mei, Chengxiang Zhai, Bruce Schatz
Research Collection School Of Computing and Information Systems
With the rapid decrease in cost of genome sequencing, the classification of gene function is becoming a primary problem. Such classification has been performed by human curators who read biological literature to extract evidence. BeeSpace Navigator is a prototype software for exploratory analysis of gene function using biological literature. The software supports an automatic analogue of the curator process to extract functions, with a simple interface intended for all biologists. Since extraction is done on selected collections that are semantically indexed into conceptual spaces, the curation can be task specific. Biological literature containing references to gene lists from expression experiments …