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Physical Sciences and Mathematics Commons

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Full-Text Articles in Physical Sciences and Mathematics

Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison Of Route-Specific Systemic Toxicity And Hazard Classifications Under The Globally Harmonized System Of Classification And Labelling Of Chemicals (Ghs), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, Tim G. Rowan Dec 2014

Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison Of Route-Specific Systemic Toxicity And Hazard Classifications Under The Globally Harmonized System Of Classification And Labelling Of Chemicals (Ghs), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, Tim G. Rowan

Troy Seidle, PhD

Acute systemic toxicity data (LD50 values) and hazard classifications derived in the rat following oral administration and dermal application have been analysed to examine whether or not orally-derived hazard classification or LD50 values can be used to determine dermal hazard classification. Comparing the oral and dermal classifications for 335 substances derived from oral and dermal LD50 values respectively revealed 17% concordance, and indicated that 7% of substances would be classified less severely while 76% would be classified more severely if oral classifications were applied directly to the dermal route. In contrast, applying the oral LD50 values within the dermal classification …


Will Fault Localization Work For These Failures? An Automated Approach To Predict Effectiveness Of Fault Localization Tools, Tien-Duy B. Le, David Lo Jun 2014

Will Fault Localization Work For These Failures? An Automated Approach To Predict Effectiveness Of Fault Localization Tools, Tien-Duy B. Le, David Lo

David LO

Debugging is a crucial yet expensive activity to improve the reliability of software systems. To reduce debugging cost, various fault localization tools have been proposed. A spectrum-based fault localization tool often outputs an ordered list of program elements sorted based on their likelihood to be the root cause of a set of failures (i.e., their suspiciousness scores). Despite the many studies on fault localization, unfortunately, however, for many bugs, the root causes are often low in the ordered list. This potentially causes developers to distrust fault localization tools. Recently, Parnin and Orso highlight in their user study that many debuggers …


Sentiment Classification Through Semantic Orientation Using Sentiwordnet, Dr. Muhammad Zubair Asghar, Dr, Auranzeb Khan Jun 2014

Sentiment Classification Through Semantic Orientation Using Sentiwordnet, Dr. Muhammad Zubair Asghar, Dr, Auranzeb Khan

Dr. Muhammad Zubair Asghar

Sentiment analysis is the procedure by which information is extracted from the opinions, appraisals and emotions of people in regards to entities, events and their attributes. In decision making, the opinions of others have a significant effect on customers ease in making choices regards to online shopping, choosing events, products, entities. In this paper, a rule based domain independent sentiment analysis method is proposed. The proposed method classifies subjective and objective sentences from reviews and blog comments. The semantic score of subjective sentences is extracted from SentiWordNet to calculate their polarity as positive, negative or neutral based on the contextual …