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Physical Sciences and Mathematics Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Ph-Dependent Fluorescent Probe That Can Be Tuned For Cysteine Or Homocysteine, Yongkang Yue, Fangjun Huo, Xiaoqi Li, Ying Wen, Tao Yi, James C. Salamanca, Jorge O. Escobedo, Robert Strongin, Caixia Yin
Ph-Dependent Fluorescent Probe That Can Be Tuned For Cysteine Or Homocysteine, Yongkang Yue, Fangjun Huo, Xiaoqi Li, Ying Wen, Tao Yi, James C. Salamanca, Jorge O. Escobedo, Robert Strongin, Caixia Yin
Chemistry Faculty Publications and Presentations
The very close structural similarities between cysteine and homocysteine present a great challenge to achieve their selective detection using regular fluorescent probes, limiting the biological and pathological studies of these two amino thiols. A coumarin-based fluorescent probe was designed featuring pH-promoted distinct turn-on followed by ratiometric fluorescence responses for Cys and turn-on fluorescence response for Hcy through two different reaction paths. These specific responses demonstrate the activity differences between Cys and Hcy qualitatively for the first time. The probe could also be used for Cys and Hcy imaging in living cells.
Exploring The Ph Dependence Of Viologen Reduction By Alpha-Carbon Radicals Derived From Hcy And Cys, Dong Wang, William E. Crowe, Robert M. Strongin, Martha Sibrian-Vazquez
Exploring The Ph Dependence Of Viologen Reduction By Alpha-Carbon Radicals Derived From Hcy And Cys, Dong Wang, William E. Crowe, Robert M. Strongin, Martha Sibrian-Vazquez
Chemistry Faculty Publications and Presentations
The colorimetric reaction of homocysteine (HCy) with a series of viologen salts suggests a linear correlation between the mid-point reduction potential of Hcy-derived α-carbon radicals and pH.