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Missouri University of Science and Technology
Acetaminophen -- Toxicology<br />Glutathione -- Molecular aspects<br />Hepatotoxicology -- Testing<br />Oxidative stress
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Full-Text Articles in Physical Sciences and Mathematics
Comparative Evaluation Of N-Acetylcysteine And N-Acetylcysteine Amide In Acetaminophen-Induced Oxidative Stress, Ahdab Naeem Khayyat
Comparative Evaluation Of N-Acetylcysteine And N-Acetylcysteine Amide In Acetaminophen-Induced Oxidative Stress, Ahdab Naeem Khayyat
Masters Theses
"Acetaminophen (APAP) is the most widely used pharmaceutical analgesic-antipyretic agent in the world, but its toxicity is a common cause of drug-induced hepatotoxicity. With APAP toxicity, cellular glutathione (GSH) is depleted. This results in the availability of N-acetyl-p-benzoquinone imine (NAPQI), is a toxic metabolite of APAP that binds to cellular macromolecules, which leads to cell necrosis. N-acetyl cysteine (NAC), a GSH precursor, is the only approved antidote for an acetaminophen overdose. It is a negatively charged molecule that diminishes its penetration into the cells, thereby requiring fairly high doses that increase the severity of side effects. In addition, oral and …