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Calcium cycling

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Full-Text Articles in Physical Sciences and Mathematics

Computational Modeling And Numerical Methods For Spaciotemporal Calcium Cycling In Ventricular Myocytes, Robert Rovetti May 2012

Computational Modeling And Numerical Methods For Spaciotemporal Calcium Cycling In Ventricular Myocytes, Robert Rovetti

Mathematics Faculty Works

Intracellular calcium (Ca) cycling dynamics in cardiac myocytes is regulated by a complex network of spatially distributed organelles, such as sarcoplasmic reticulum (SR), mitochondria, and myofibrils. In this study, we present a mathematical model of intracellular Ca cycling and numerical and computational methods for computer simulations. The model consists of a coupled Ca release unit (CRU) network, which includes a SR domain and a myoplasm domain. Each CRU contains 10 L-type Ca channels and 100 ryanodine receptor channels, with individual channels simulated stochastically using a variant of Gillespie’s method, modified here to handle time-dependent transition rates. Both the SR domain …

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Computational Modeling And Numerical Methods For Spatiotemporal Calcium Cycling In Ventricular Myocytes, Michael Nivala, Enno De Lange, Robert J. Rovetti, Zhilin Qu May 2012

Computational Modeling And Numerical Methods For Spatiotemporal Calcium Cycling In Ventricular Myocytes, Michael Nivala, Enno De Lange, Robert J. Rovetti, Zhilin Qu

Mathematics Faculty Works

Intracellular calcium (Ca) cycling dynamics in cardiac myocytes is regulated by a complex network of spatially distributed organelles, such as sarcoplasmic reticulum (SR), mitochondria, and myofibrils. In this study, we present a mathematical model of intracellular Ca cycling and numerical and computational methods for computer simulations. The model consists of a coupled Ca release unit (CRU) network, which includes a SR domain and a myoplasm domain. Each CRU contains 10 L-type Ca channels and 100 ryanodine receptor channels, with individual channels simulated stochastically using a variant of Gillespie’s method, modified here to handle time-dependent transition rates. Both the SR domain …

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