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Articles 1 - 8 of 8
Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Oligopyridine Ligands Directed Towards Water Soluble Metal Complexes For The Decomposition Of Organophosphates, Jeremy Bloch
Synthesis Of Oligopyridine Ligands Directed Towards Water Soluble Metal Complexes For The Decomposition Of Organophosphates, Jeremy Bloch
Landmark Conference Summer Research Symposium
Our experimental focus is on the design and synthesis of oligopyridine based ligands for the synthesis of metal complexes that will be used to detoxify model compounds of organophosphate-based nerve agents and/or pesticides by hydrolysis or by acting as oxidizing agents.
Luminescent Metal-Organic Frameworks, Lucas Stehle, Kaitlyn Mercando
Luminescent Metal-Organic Frameworks, Lucas Stehle, Kaitlyn Mercando
Landmark Conference Summer Research Symposium
Metal-organic frameworks (MOFs), porous materials composed of metal ions and organic linkers, have broad applications in separation, small molecule storage, and catalysis. Luminescent metalorganic frameworks (LMOFs) hold great potential in the development of sensors, and, with their relatively straightforward syntheses that produce predictable, homogeneous, extended structures, should result in good sensor-to-sensor reproducibility and uniform response. In addition, subtle differences in overall LMOF structure, metal ion coordination, pore surfaces, and host-guest interactions within pores should have significant impact on observed photoluminescence and provide numerous strategies for analyte detection. Highlighted here is the development of LMOFs composed of zinc or zirconium ions …
Synthesis Of An Amide-Based Extended Heterocyclic System Capable Of Hydrogen Bonding To Both The Adenine And Uracil In Dsrna For Rna Recognition Using Pna, John M. Talbott, Aubrey L. Maryniak
Synthesis Of An Amide-Based Extended Heterocyclic System Capable Of Hydrogen Bonding To Both The Adenine And Uracil In Dsrna For Rna Recognition Using Pna, John M. Talbott, Aubrey L. Maryniak
Landmark Conference Summer Research Symposium
The majority of information known about RNA is centered around coding RNA for its role in synthesizing proteins from DNA. However, noncoding RNA is also biologically relevant, showing importance in gene expression and catalyzing reactions. Peptide Nucleic Acids, or PNAs, are a promising tool that can be used to study noncoding RNA. PNAs can bind to double-stranded RNA forming a triple helix and are highly selective for specific sequences of dsRNA. A current limitation of PNA as a ligand is that traditional nucleobases only bind with high affinity to single purine residues on the RNA, as triplex formation relies on …
Exploring The Synthesis Of Substituted Porphyrins, Christina Schnee
Exploring The Synthesis Of Substituted Porphyrins, Christina Schnee
Landmark Conference Summer Research Symposium
A current theme in our research laboratory is the development of low cost methods for the synthesis of lamellar vesicles as models for cell membranes. These vesicles, serving as simplified artificial cells, allow us to examine fundamental properties of the membrane including transport of materials across the membrane. Vesicles of varying size can also be employed as molecule delivery systems for a variety of compounds, including pharmaceuticals. We are especially interested in pharmaceuticals used in photodynamic therapy. This type of medical intervention entails delivery of a prodrug (one which is not initially bio-active). Upon exposure to a specific wavelength of …
Synthesis And Characterization Of A Tris(Phenolate)Amine Ligand For The Production Of An Iron(Iii)-Centered Catalyst, Caden Pensak, Marie Heidledr, Abby Betar
Synthesis And Characterization Of A Tris(Phenolate)Amine Ligand For The Production Of An Iron(Iii)-Centered Catalyst, Caden Pensak, Marie Heidledr, Abby Betar
Landmark Conference Summer Research Symposium
The use of tris(phenol)amines in the synthesis of iron(III)-based catalysts has been essential to the production of semi-aromatic polymers from epoxides and cyclic anhydrides. In order to create the iron(III)-centered catalytic compound, (ArMeO)3NFe(DMAP), however, we must first be able to reliably create it’s uncoordinated organic ligand in high yields. The goal of this project is to find the variables that optimize the synthesis of the tris(2-hydroxy-4,6-dimethylbenzyl)amine using hexamethylenetetramine, 2,4-dimethylphenol, and catalytic amounts of p-toluenesulfonic acid. We have performed experiments on the molar ratios of reactants, atmosphere, temperature, purification, and stirring for the synthesis. We have also characterized the results via …
Applying Machine Learning To Encrypted Network Traffic For Malware Detection, Derek Manning
Applying Machine Learning To Encrypted Network Traffic For Malware Detection, Derek Manning
Landmark Conference Summer Research Symposium
The landscape of network analysis is ever-evolving as the fields of technology and business progress. While the landscape of the analysis may change, at the core of network analysis is the detection of malicious activity. In real-time traffic flow, it is non-trivial to determine whether a particular flow is malicious in nature. Most malicious software (malware) analysis is done after the flow has already reached its end target, and is analyzed in the form of network traffic captures. For any network analysis system, it is important that the privacy of the data being transmitted it not compromised in the process. …
Development Of A One-Pot Allylation And Claisen Rearrangement Of Acetaminophen By Applying Microwave Radiation, Brandon R. Tessier
Development Of A One-Pot Allylation And Claisen Rearrangement Of Acetaminophen By Applying Microwave Radiation, Brandon R. Tessier
Landmark Conference Summer Research Symposium
The Claisen rearrangement is a widely applicable organic reaction that involves the shift of a sigma bond across the pi-system of an allyl vinyl ether to produce allylated phenols. In this project, we aim to develop a microwave assisted allylation of a phenol, followed by a subsequent Claisen rearrangement in one pot. The goals of this project are three-fold. First, we aim to accelerate these reactions using microwave assisted organic synthesis because to date, microwave technology has been sparsely used in Claisen chemistry. Second, we aim to perform these reactions in a single pot, enhancing the simplicity and elegance of …
Detection Of Heavy Metals By Colorimetric Nanoparticles, Rachel Molino, Michael Perzel
Detection Of Heavy Metals By Colorimetric Nanoparticles, Rachel Molino, Michael Perzel
Landmark Conference Summer Research Symposium
In the United States there are 6.1 million lead water service lines. This fact leaves many Americans in a precarious situation, as slight changes in the properties of their water supply (ex. pH), could result in the leaching of lead into their drinking water. Unfortunately, the average person does not have the ability to test for lead in water. This problem exists because current technologies for lead detection are expensive and require trained personnel. To address this issue, we propose a simple and inexpensive paper test for lead(II) in drinking water. This test will utilize polymer nanoparticles, which encapsulate a …