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Full-Text Articles in Physical Sciences and Mathematics
Identifying Taphonomic Distribution Patterns At The Gray Fossil Site, Shawn Haugrud
Identifying Taphonomic Distribution Patterns At The Gray Fossil Site, Shawn Haugrud
Electronic Theses and Dissertations
Since the early days of the discovery of the Gray Fossil Site (GFS), meticulous efforts to preserve the spatial data were a priority. Direct surveying of fossils prior to recovery, as well as grid mapping the site, provided relative spatial data within a square meter. Such efforts meant that even fragments and microfossils, recovered during the screening operations and eventual concentrate picking, maintained some spatial data. Available spatial data are used to identify smaller deposits within the greater system, as well as non-random distribution patterns among a number of GFS taxa. Patterns are particularly pronounced in the large-bodied taxa, Teleoceras …
A Physiologically-Based Pharmacokinetic Model For The Antibiotic Levofloxacin, Paezha M. Mccartt
A Physiologically-Based Pharmacokinetic Model For The Antibiotic Levofloxacin, Paezha M. Mccartt
Undergraduate Honors Theses
Levofloxacin is in a class of antibiotics known as fluoroquinolones, which treat infections by killing the bacteria that cause them. A physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake, distribution, and elimination of Levofloxacin after a single dose. PBPK modeling uses parameters such as body weight, blood flow rates, partition coefficients, organ volumes, and several other parameters in order to model the distribution of a particular drug throughout the body. Levofloxacin is only moderately bound in human blood plasma, and, thus, for the purposes of this paper, linear bonding is incorporated into the model because the free or …
A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White
A Physiologically-Based Pharmacokinetic Model For Vancomycin, Rebekah White
Undergraduate Honors Theses
Vancomycin is an antibiotic used for the treatment of systemic infections. It is given
intravenously usually every twelve or twenty-four hours. This particular drug has a
medium level of boundedness, with approximately fty percent of the drug being free
and thus physiologically eective. A physiologically-based pharmacokinetic (PBPK)
model was used to better understand the absorption, distribution, and elimination of
the drug. Using optimal parameters, the model could be used in the future to test
how various factors, such as BMI or excretion levels, might aect the concentration
of the antibiotic.