Physical Sciences and Mathematics Commons^™

Examination Of The B Coefficient In Gap Crystal Utilizing Single And Double Photon Absorption, Ines Kusmic

College of Science and Health Theses and Dissertations

A laser of 0.800 mm at 100 fs is utilized in obtaining a b coefficient in a GaP crystal associated with double photon absorption. Data is collected for the incident power of the laser for both single and double photon absorption, and it is plotted against the signal generated in the photodiode containing the GaP crystal. The slope of such a plot is employed in calculating b with equations derived in the theoretical model that is unique to the present work. The data for single photon absorption is utilized in calculating the thickness of the GaP crystal, while the data …

An Application Of Wavelet Methods To The Search For Baryon Acoustic Oscillations, Kevin Michael Kadowaki

College of Science and Health Theses and Dissertations

We use the method of wavelet transforms to investigate the clustering of matter on galactic scales in search of Baryon Acoustic Oscillations (BAOs). In particular, we develop a method of wavelet packet analysis to measure the power spectrum of a galaxy distribution and apply this method to the CMASS galaxy catalogue from the Sloan Digital Sky Survey (SDSS) Baryon Oscillation Spectroscopic Survey (BOSS) collaboration. Using a variant of HEALPix, we project the data from the celestial sphere onto a square signal matrix, and take the two-dimensional Wavelet Packet Transform of this signal. We use this transform and techniques of spectrum …

Enzyme-Mediated And Mechanistic Investigations Of Tetrahydroisoquinoline Synthesis Through The Pictet-Spengler Reaction, Jordan Elise Fauser

College of Science and Health Theses and Dissertations

Tetrahydroisoquinolines (THI) are biologically active natural products with applications to a variety of diseases. These compounds also act as precursors for other pharmacologically active natural products. In this investigation, a new synthetic approach for generation of halogenated THIs was proposed. Using cross-linked tyrosinase aggregate, halogenated tyrosine and tyramine were oxidized to form halogenated catechols such as halogenated L-DOPA and dopamine. In a one-pot synthetic approach, the enzyme oxidation reaction was coupled to the Pictet-Spengler reaction, through the addition of an aldehyde, to generate halogenated THIs. The Pictet-Spengler reaction was catalyzed by the phosphate buffer in the reaction solution. The role …

Chemical Reaction Kinetics Of The Pictet-Spengler Reaction, Jo Ann K. Girel

College of Science and Health Theses and Dissertations

There is an extensive history of the use of alkaloids for medicinal purposes. Today, development of novel pharmaceutical alkaloids is imperative to developing effective drugs. The Pictet-Spengler reaction of dopamine with 4-hydroxyphenyl-acetaldehyde is the first step in the biosynthesis of thousands of known alkaloids. In this reaction, mechanisms have been proposed to explain the specificity of phosphate catalysis. However, the uniqueness of the phosphate ion in the Pictet-Spengler reaction is not explained. The Pictet-Spengler reaction of dopamine with propanal in phosphate buffer and in maleic acid buffer were evaluated and determined to be comparable. The reaction was found to be …

Using A Dynamic Domain-Specific Modeling Language For The Model-Driven Development Of Cross-Platform Mobile Applications, Christopher A. Jones

College of Computing and Digital Media Dissertations

There has been a gradual but steady convergence of dynamic programming languages with modeling languages. One area that can benefit from this convergence is modeldriven development (MDD) especially in the domain of mobile application development. By using a dynamic language to construct a domain-specific modeling language (DSML), it is possible to create models that are executable, exhibit flexible type checking, and provide a smaller cognitive gap between business users, modelers and developers than more traditional model-driven approaches.

Dynamic languages have found strong adoption by practitioners of Agile development processes. These processes often rely on developers to rapidly produce working code …