Physical Sciences and Mathematics Commons^™

Multiwavelength X-Ray Diffraction, Maziar Saleh Ziabari

College of Science and Health Theses and Dissertations

The central problem of diffraction theory is determining the structure of an object given only the intensity of its diffraction pattern. In general, both the amplitude and phase must be known to uniquely solve a structure; however a coherent radiation source is usually required in order to measure the diffacted phases (e.g. in holography). In many important cases, coherent sources are unavailable and other assumptions or methods must be employed to substitute for the missing phase information. One method that has been successfully applied to the specific problem of determining atomic structure from X-ray diffraction intensity patterns has been the …

Supporting Adult Learners' Metacognitive Development With A Sociotechnical System, Kathryn Wozniak

College of Computing and Digital Media Dissertations

Metacognition is defined as thinking about and reflecting on one's cognitive processes. In learning contexts, strong metacognition leads to retention, academic success, and deep learning. While we know a lot about the metacognition of learners in grades K-12 and college, there are limited studies on adult learners' (24 and older) metacognitive awareness, how to support it, or the role technology can play, particularly since e-learning is quickly becoming the central mode of learning for adult learners. Thus, I have the following motivating research question: How can we support adult learners' metacognitive development in e-learning environments?

To better understand adult learners' …

Synthesis And Exploration Of Dopamine And 4‐ Hpaa Analogs For Norcoclaurine Synthase, Arthur A. Ralko

College of Science and Health Theses and Dissertations

Precursor directed biosynthesis (PDB) presents a useful approach for modifying large scale drug and drug lead mole cules . Large molecular structures are synthetically modified as part of total synthesis approach, and often result in l ow yield and expensive r eagents. Of particular interest are plant alkaloid drugs, many of which come from tetrahydroisoquinoline (THI) precursor. We present an organic synthesis of novel dopamine and 4 - hydroxyphenacetaldehyde (4-HPAA) analogs as precursors for enzymatic conversion to tetrahydroisoquinoline analogs using norcoclaurine synthase (NCS) . Modifications for investigation include halogenation of the 2 and 5 positions of the aromatic ring and …