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Articles 1 - 8 of 8
Full-Text Articles in Physical Sciences and Mathematics
Communicator-In-Chief: Presidential Use Of Television Past, Present, And Future, Jenna Wasson
Communicator-In-Chief: Presidential Use Of Television Past, Present, And Future, Jenna Wasson
Honors Theses
This thesis seeks to determine how television has changed as a communication medium for presidents over the past half century. An evaluation of the evolving ways presidents use television to communicate with and to build support from the American people has been conducted. Presidential communication strategies have been identified by drawing primarily from primary sources written by presidents and White House staff. Television technology and the television audience have changed over the years. Presidents have taken a more pro-active, aggressive role in their efforts to harness television for their own purposes. Why have these changes occurred? What impact have these …
Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Synthesis And Dna Binding Of Cis And Trans-Rucl2 (Dmso)4, Thomas Curran
Honors Theses
The synthesis of both cis and trans-RuCl?(DMSO)? has been reported in literature, and is currently the only way of acquiring these compounds. Because these metallodrugs have shown similar antitumor properties to cisplatin, they are currently under investigation for use in clinical trials as potential chemotherapeutics. It is believed that these drugs act in a way similar to cisplatin by causing intrastrand crosslinking of adjacent guanine residues in DNA. In an attempt to better understand any Ru/DNA interaction for these compounds, both cis and trans-RuCl?(DMSO)? were synthesized with reasonable yields (~40%). The compounds were then characterized by nuclear magnetic resonance (NMR), …
Purification Of The Hmg1 Protein And Investigation Of Its Interactions With Diepoxide Cross-Linked Dna, Gayle Pageau
Purification Of The Hmg1 Protein And Investigation Of Its Interactions With Diepoxide Cross-Linked Dna, Gayle Pageau
Honors Theses
HMG1 is a nonhistone chromosomal protein that binds preferentially to some types of globally modified DNA. HMG1 has been implicated in the cellular response to the anti-cancer agent cisplatin, functioning to block excision repair of specific distorted platinated DNA lesions and resulting in enhanced cytotoxicity. We have investigated whether other DNA-binding agents also produce lesions that are recognized by HMG1. Specifically, we used polyacrylamide gel shift assays to monitor the potential HMG1 binding of diepoxybutane interstrand cross-links, which have been suggested to induce DNA bending. We isolated the native protein from chicken erythrocytes and expressed engineered HMG domain proteins in …
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Effect Of 6-Thioguanine And Methyl-6-Thioguanine On Stability Of Dna Duplexes, Mabaera Rodwell
Honors Theses
6-Thioguanine (65G) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia. Despite its long-standing clinical use, little is understood of the molecular basis of the cytotoxicity associated with ?sG. Research has shown that ?sG is incorporated into DNA during replication after which it may exert its cytotoxicity by inducing rapid mutation or by affecting DNA-protein interactions. 65G has also been shown to impair HIV replication by inhibiting HlV-l reverse transcriptase and to inhibit human telomerase activity. To further understand the structural changes associated …
Modeling A Real-Time Economics Simulation With User-Coded Agents In An Object-Oriented Database, Kevin Simons
Modeling A Real-Time Economics Simulation With User-Coded Agents In An Object-Oriented Database, Kevin Simons
Honors Theses
A simulation tbat models the stock market with real-time stock quotes was created. Users can translate their own theories about investing into Java code, which is then used to create an intelligent agent. The agent is inserted into the simulation, which allows the agent to gather data from the model. Based on this data, the agent uses the algorithm the user wrote to buy and sell stocks. Such as model provides a means of testing investment theories before investing.
Investigations Of Intramolecular Copper (I)-Arene Interactions Using A Ns2-Macrocyclic Ligand With Different Pendant Aryl Arms, Paul J. Lee
Honors Theses
Two macrocyclic ligands with a pendant phenyl group -N-[2-(l-phenyl)ethyl]-1-aza-4,8di thiacyclodecane (L1) and N-[2-0-phenyl)propyl]-1-aza-4,8-dithiacyclodecane, (L2) has been synthesized and characterized. The copper(I)-triphenylphosphine complex [LICu(PPhJ)]OTf , (2) was synthesized from L1 1/2(C6H6)[CuOTf]2, and PPh3. The complexes [LICu]OTf 1 and [L2Cu]OTf 3 were also synthesized and characterized using DC and IH NMR, UV-vis and lR spectroscopy, and ESI-MS. In CD2Cl2, 1 was found to have a fluxional behavior with the barrier ΔG to the process estimated at 9-11 kcal/mol. Variable temp. NMR spectroscopy of 1 gave compelling evidence that the phenylappended group is bound in an intramolecullar η2-fashion with the copper center. At …
Photochemical Generation And Chemistry Of Α-Acetoxycarbene, Jonathan Mann
Photochemical Generation And Chemistry Of Α-Acetoxycarbene, Jonathan Mann
Honors Theses
Efforts have been made at generating the parent α-acetoxycarbene from a non-nitrogenous precursor. Baeyer-Villiger oxidation of the ketone, 1-(1a,9b-dihydro-lHcyclopropa[1] phenanthren-1-yl)-ethanone, available in two steps from phenanthrene, led to the ester, 1-(1 a,9b-dihydro-lH-cyclopropa[/]phenanthren-l-yl)-acetate, which is a photochemical precursor of the parent α-acetoxycarbene intermediate. Photolysis of the ester in cyclohexene afforded an isomeric mixture of endo and exo acetates resulting from the carbene adding to the α-bond. Photolysis of the ester in trans-3-hexene yielded a single trans-cis acetate, a product of the same cycloaddition process. The formation of methyl glyoxal, via the l,2-acyl shift of the carbene, is observed through its derivatives. …
Local Participation As A Determinant Of Success In World Bank Environmental Projects: What Is The Evidence?, Catherine Benson
Local Participation As A Determinant Of Success In World Bank Environmental Projects: What Is The Evidence?, Catherine Benson
Honors Theses
The current impoverished, environmentally degraded state of Africa suggests that international aid projects have proven largely unsuccessful in tackling the enormous development and environment challenges faced by Africa. Africa has historically been inundated with groups trying to implement change in the form of political, economic, and environmental agendas, beginning in the colonial period and continuing today. The abundance of advice and financial assistance poured into this region have resulted in a continent lagging behind other developing regions to an even worse extent than prior to aid projects. The environment of development in Africa is complex; nowhere else in the world …