Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Cleveland State University

2010

Discipline
Keyword
Publication
Publication Type

Articles 1 - 30 of 49

Full-Text Articles in Physical Sciences and Mathematics

Closed-Range Composition Operators On A2 And The Bloch Space, John R. Akeroyd, Pratibha G. Ghatage, Maria Tjani Dec 2010

Closed-Range Composition Operators On A2 And The Bloch Space, John R. Akeroyd, Pratibha G. Ghatage, Maria Tjani

Mathematics and Statistics Faculty Publications

For any analytic self-map φ of {z : |z| < 1} we give four separate conditions, each of which is necessary and sufficient for the composition operator Cφ to be closed-range on the Bloch space B . Among these conditions are some that appear in the literature, where we provide new proofs. We further show that if Cφ is closed-range on the Bergman space A2 , then it is closed-range on B , but that the converse of this fails with a vengeance. Our analysis involves an extension of the Julia-Carathéodory Theorem.

Go to article

Putting Artists On The Map: A Five Part Study Of Greater Cleveland Artists' Location Decisions - Part 2: Profiles Of Artist Neighborhoods, Mark Salling, Gregory Soltis, Charles Post, Sharon Bliss, Ellen Cyran Nov 2010

Putting Artists On The Map: A Five Part Study Of Greater Cleveland Artists' Location Decisions - Part 2: Profiles Of Artist Neighborhoods, Mark Salling, Gregory Soltis, Charles Post, Sharon Bliss, Ellen Cyran

All Maxine Goodman Levin School of Urban Affairs Publications

A series of reports detailing the residential and work space location preferences of Cuyahoga county's artists.

Go to article

[Fe-Fe]-Hydrogenase Reactivated By Residue Mutations As Bridging Carbonyl Rearranges: A Qm/Mm Study, Stefan Motiu, Valentin Gogonea Nov 2010

[Fe-Fe]-Hydrogenase Reactivated By Residue Mutations As Bridging Carbonyl Rearranges: A Qm/Mm Study, Stefan Motiu, Valentin Gogonea

Chemistry Faculty Publications

In this work, we found aqueous enzyme phase reaction pathways for the reactivation of the exogenously inhibited [Fe-Fe]-hydrogenases by O2, or OH−, which metabolizes to H2O (Dogaru et al., Int J Quantum Chem 2008, 108; Motiu et al., Int J Quantum Chem 2007, 107, 1248). We used the hybrid quantum mechanics/molecular mechanics (QM/MM) method to study the reactivation pathways of the exogenously inhibited enzyme matrix. The ONIOM calculations performed on the enzyme agree with experimental results (Liu et al., J Am Chem Soc 2002, 124, 5175), that is, wild-type [Fe-Fe]-hydrogenase H-cluster is inhibited by oxygen metabolites. An enzyme spherical region …

Go to article

Dnmt1 Stability Is Regulated By Proteins Coordinating Deubiquitination And Acetylation-Driven Ubiquitination, Zhanwen Du, Jing Song, Yong Wang, Yiqing Zhao, Kishore Guda, Shuming Yang, Hung Ying Kao, Yan Xu, Joseph Willis, Sanford D. Markowitz, David Sedwick, Robert M. Ewing, Zhenghe Wang Nov 2010

Dnmt1 Stability Is Regulated By Proteins Coordinating Deubiquitination And Acetylation-Driven Ubiquitination, Zhanwen Du, Jing Song, Yong Wang, Yiqing Zhao, Kishore Guda, Shuming Yang, Hung Ying Kao, Yan Xu, Joseph Willis, Sanford D. Markowitz, David Sedwick, Robert M. Ewing, Zhenghe Wang

Chemistry Faculty Publications

DNA methyltransferase 1 (DNMT1) is the primary enzyme that maintains DNA methylation. We describe a previously unknown mode of regulation of DNMT1 protein stability through the coordinated action of an array of DNMT1-associated proteins. DNMT1 was destabilized by acetylation by the acetyltransferase Tip60, which triggered ubiquitination by the E3 ligase UHRF1, thereby targeting DNMT1 for proteasomal degradation. In contrast, DNMT1 was stabilized by histone deacetylase 1 (HDAC1) and the deubiquitinase HAUSP (herpes virus–associated ubiquitin-specific protease). Analysis of the abundance of DNMT1 and Tip60, as well as the association between HAUSP and DNMT1, suggested that during the cell cycle the initiation …

Go to article

Cox-2 Inhibitor Nimesulide Analogs Are Aromatase Suppressors In Breast Cancer Cells, Bin Su, Xiaohan Cai, Yanyan Hong, Shiuan Chen Oct 2010

Cox-2 Inhibitor Nimesulide Analogs Are Aromatase Suppressors In Breast Cancer Cells, Bin Su, Xiaohan Cai, Yanyan Hong, Shiuan Chen

Chemistry Faculty Publications

Cyclooxygenase-2 (COX-2) inhibitor nimesulide derivatives compounds A and B decreased aromatase activity in breast cancer cells via a novel mechanism different to aromatase inhibitors (AIs), and were defined as “aromatase suppressors”. Breast carcinoma cells (MCF-7aro and T47Daro) transfected with aromatase full gene were used to explore the mechanisms of the two compounds. They dose and time-dependently suppressed aromatase activity in MCF-7aro and T47Daro cells in the nanomole range. However, they neither directly inhibited aromatase, nor improved aromatase degradation even at much higher concentrations. They could also suppress androgen stimulated cell growth, but did not affect estrogen enhanced cell proliferation. These …

Go to article

Formulation Of The Dutch Atmospheric Large-Eddy Simulation (Dales) And Overview Of Its Applications, Thijs Heus, C. C. Van Heerwaarden, Harmen J.J. Jonker, A. Pier Siebesma, S. Axelsen, K. Van Den Dries, O. Geoffroy, A. F. Moene, D. Pino, S. R. De Roode, J. Vilà-Guerau De Arellano Sep 2010

Formulation Of The Dutch Atmospheric Large-Eddy Simulation (Dales) And Overview Of Its Applications, Thijs Heus, C. C. Van Heerwaarden, Harmen J.J. Jonker, A. Pier Siebesma, S. Axelsen, K. Van Den Dries, O. Geoffroy, A. F. Moene, D. Pino, S. R. De Roode, J. Vilà-Guerau De Arellano

Physics Faculty Publications

The current version of the Dutch Atmospheric Large-Eddy Simulation (DALES) is presented. DALES is a large-eddy simulation code designed for studies of the physics of the atmospheric boundary layer, including convective and stable boundary layers as well as cloudy boundary layers. In addition, DALES can be used for studies of more specific cases, such as flow over sloping or heterogeneous terrain, and dispersion of inert and chemically active species. This paper contains an extensive description of the physical and numerical formulation of the code, and gives an overview of its applications and accomplishments in recent years.

Go to article

Mechanochemistry Of Hexagonal Boron Nitride: 1. Destruction And Amorphization During Mechanical Treatment, A. N. Streletskii, D. G. Permenov, Kiril A. Streletzky, B. B. Bokhonov, A. V. Leonov Aug 2010

Mechanochemistry Of Hexagonal Boron Nitride: 1. Destruction And Amorphization During Mechanical Treatment, A. N. Streletskii, D. G. Permenov, Kiril A. Streletzky, B. B. Bokhonov, A. V. Leonov

Physics Faculty Publications

The regularities of the mechanical activation of hexagonal boron nitride are analyzed using the X-ray diffraction, IR spectroscopy, transmission electron microscopy, dynamic light scattering, and adsorption methods. At the initial state of mechanical activation, the main process is material destruction. At this stage, the specific surface area increases to 400 m2/g and crystallographically oriented nanosized needles are formed. At the same time, boron nitride crystal structure is disordered with an increase in interplanar distance d(002). The disordering is assumed to be due to a shift along planes (001). At a specific dose of supplied mechanical energy above 6–8 kJ/g, the …

Go to article

Residue Mutations In [Fe-Fe]-Hydrogenase Impedes O 2 Binding: A Qm/Mm Investigation, Daniela Dogaru, Stefan Motiu, Valentin Gogonea Aug 2010

Residue Mutations In [Fe-Fe]-Hydrogenase Impedes O 2 Binding: A Qm/Mm Investigation, Daniela Dogaru, Stefan Motiu, Valentin Gogonea

Chemistry Faculty Publications

[Fe-Fe]-hydrogenases are enzymes that reversibly catalyze the reaction of protons and electrons to molecular hydrogen, which occurs in anaerobic media. In living systems, [Fe-Fe]-hydrogenases are mostly used for H(2) production. The [Fe-Fe]-hydrogenase H-cluster is the active site, which contains two iron atoms. The latest theoretical investigations1,2 advocate that the structure of di-iron air inhibited species are either Fe(p) (II)-Fe(d) (II)-O-H(-), or Fe(p) (II)-Fe(d) (II)-O-O-H, thus O(2) has to be prevented from binding to Fe(d) in all di-iron subcluster oxidation states in order to retain a catalytically active enzyme. By performing residue mutations on [Fe-Fe]-hydrogenases, we were able to weaken O(2) …

Go to article

Comprehensive Peroxidase-Based Hematologic Profiling For The Prediction Of 1-Year Myocardial Infarction And Death, Marie Luise Brennan, Anupama Reddy, W.H. Wilson Tang, Yuping Wu, Danielle M. Brennan, Amy Hsu, Shirley A. Mann, Peter L. Hammer, Stanley L. Hazen Jul 2010

Comprehensive Peroxidase-Based Hematologic Profiling For The Prediction Of 1-Year Myocardial Infarction And Death, Marie Luise Brennan, Anupama Reddy, W.H. Wilson Tang, Yuping Wu, Danielle M. Brennan, Amy Hsu, Shirley A. Mann, Peter L. Hammer, Stanley L. Hazen

Mathematics and Statistics Faculty Publications

Background— Recognition of biological patterns holds promise for improved identification of patients at risk for myocardial infarction (MI) and death. We hypothesized that identifying high- and low-risk patterns from a broad spectrum of hematologic phenotypic data related to leukocyte peroxidase-, erythrocyte- and platelet-related parameters may better predict future cardiovascular risk in stable cardiac patients than traditional risk factors alone. Methods and Results— Stable patients (n=7369) undergoing elective cardiac evaluation at a tertiary care center were enrolled. A model (PEROX) that predicts incident 1-year death and MI was derived from standard clinical data combined with information captured by a high-throughput peroxidase-based …

Go to article

Correlation-Based Traffic Analysis Attacks On Anonymity Networks, Ye Zhu, Xinwen Fu, Byran Gramham, Riccardo Bettati, Wei Zhao Jul 2010

Correlation-Based Traffic Analysis Attacks On Anonymity Networks, Ye Zhu, Xinwen Fu, Byran Gramham, Riccardo Bettati, Wei Zhao

Electrical and Computer Engineering Faculty Publications

In this paper, we address attacks that exploit the timing behavior of TCP and other protocols and applications in low-latency anonymity networks. Mixes have been used in many anonymous communication systems and are supposed to provide countermeasures to defeat traffic analysis attacks. In this paper, we focus on a particular class of traffic analysis attacks, flow-correlation attacks, by which an adversary attempts to analyze the network traffic and correlate the traffic of a flow over an input link with that over an output link. Two classes of correlation methods are considered, namely time-domain methods and frequency-domain methods. Based on our …

Go to article

Debye Series For Light Scattering By A Coated Nonspherical Particle, Feng Xu, James A. Lock Jun 2010

Debye Series For Light Scattering By A Coated Nonspherical Particle, Feng Xu, James A. Lock

Physics Faculty Publications

By using the extended boundary condition method, the Debye series is developed for light scattered by a coated nonspherical particle in order to interpret the angular dependence of the scattered intensity in terms of various physical processes. Numerical calculations are performed to study the influence of the coating thickness and the ellipticity of a coated spheroid on the angular position of the alpha and beta primary rainbows, which are produced by partial waves experiencing one internal reflection. The hyperbolic umbilic focal section is demonstrated and is analyzed for both the alpha and the beta rainbows.

Go to article

An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking Via The Chemokine Receptor Ccr2, A Model For Tumorigenesis, Ge Jin, Hameem I. Kawsar, Stanley A. Hirsch, Chun Zeng, Xun Jia, Zhimin Feng, Santosh K. Ghosh, Qing Yin Zheng, Aimin Zhou, Thomas M. Mcintyre, Aaron Weinberg Jun 2010

An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking Via The Chemokine Receptor Ccr2, A Model For Tumorigenesis, Ge Jin, Hameem I. Kawsar, Stanley A. Hirsch, Chun Zeng, Xun Jia, Zhimin Feng, Santosh K. Ghosh, Qing Yin Zheng, Aimin Zhou, Thomas M. Mcintyre, Aaron Weinberg

Chemistry Faculty Publications

Background: Tumor-associated macrophages (TAMs) constitute a significant part of infiltrating inflammatory cells that are frequently correlated with progression and poor prognosis of a variety of cancers. Tumor cell-produced human β-defensin-3 (hBD-3) has been associated with TAM trafficking in oral cancer; however, its involvement in tumor-related inflammatory processes remains largely unknown. Methodology: The relationship between hBD-3, monocyte chemoattractant protein-1 (MCP-1), TAMs, and CCR2 was examined using immunofluorescence microscopy in normal and oral carcinoma in situ biopsy specimens. The ability of hBD-3 to chemoattract host macrophages in vivo using a nude mouse model and analysis of hBD-3 on monocytic cell migration in …

Go to article

Dna Polymerases: Perfect Enzymes For An Imperfect World, Anthony J. Berdis May 2010

Dna Polymerases: Perfect Enzymes For An Imperfect World, Anthony J. Berdis

Chemistry Faculty Publications

This Special Thematic Issue explores the molecular properties of DNA polymerases as extraordinary biological catalysts. In this short introductory chapter, I briefly highlight some of the most important concepts from the articles contained within this Special Issue. The contents of this Special Issue are arranged into distinct sub-categories corresponding to mechanistic studies of faithful DNA polymerization, studies of "specialized" DNA polymerases that function on damaged DNA, and DNA polymerases that are of therapeutic importance against various diseases. Emphasis is placed on understanding the dynamic cellular roles and biochemical functions of DNA polymerases, and how their structure and mechanism impact their …

Go to article

Non-Natural Nucleotides As Probes For The Mechanism And Fidelity Of Dna Polymerases, Irene Lee, Anthony J. Berdis May 2010

Non-Natural Nucleotides As Probes For The Mechanism And Fidelity Of Dna Polymerases, Irene Lee, Anthony J. Berdis

Chemistry Faculty Publications

DNA is a remarkable macromolecule that functions primarily as the carrier of the genetic information of organisms ranging from viruses to bacteria to eukaryotes. The ability of DNA polymerases to efficiently and accurately replicate genetic material represents one of the most fundamental yet complex biological processes found in nature. The central dogma of DNA polymerization is that the efficiency and fidelity of this biological process is dependent upon proper hydrogen-bonding interactions between an incoming nucleotide and its templating partner. However, the foundation of this dogma has been recently challenged by the demonstration that DNA polymerases can effectively and, in some …

Go to article

Terminal Deoxynucleotidyl Transferase: The Story Of A Misguided Dna Polymerase, Edward A. Motea, Anthony J. Berdis May 2010

Terminal Deoxynucleotidyl Transferase: The Story Of A Misguided Dna Polymerase, Edward A. Motea, Anthony J. Berdis

Chemistry Faculty Publications

Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event. There is, however, one unique DNA polymerase designated terminal deoxynucleotidyl transferase that performs DNA synthesis using only single-stranded DNA as the nucleic acid substrate. In this chapter, we review the biological role of this enigmatic DNA polymerase and the biochemical mechanism for its ability to perform DNA synthesis in the absence of a templating strand. We compare and contrast the molecular events for template-independent DNA synthesis catalyzed by terminal …

Go to article

Nanostructured Poly(3,4-Ethylenedioxythiophene)–Metalloporphyrin Films: Improved Catalytic Detection Of Peroxynitrite, Serban Peteu, Pubudu Peiris, Ermias Gebermichael, Mekki Bayachou Apr 2010

Nanostructured Poly(3,4-Ethylenedioxythiophene)–Metalloporphyrin Films: Improved Catalytic Detection Of Peroxynitrite, Serban Peteu, Pubudu Peiris, Ermias Gebermichael, Mekki Bayachou

Chemistry Faculty Publications

We investigated in this paper the sensing performance of inherently conductive polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), functionalized with hemin (iron protoporphyrin) as an electrocatalytic reporter. The sensing platform is prepared by electrodeposition of a composite film of hemin–PEDOT on a 30-μm diameter carbon fiber electrode (CFE). The polymerized films were characterized by field emission scanning electron microscopy (FESEM), which pointed to nanostructured films with tortuous pores. The electrocatalytic oxidation of peroxynitrite was characterized by cyclic voltammetry as well as other electrochemical methods. The catalytic current is proportional to the analyte's concentration. Optimized hemin–PEDOT modified CFEs were utilized for the first time to …

Go to article

Debye Series For Light Scattering By A Spheroid, Feng Xu, James A. Lock, Cameron Tropea Apr 2010

Debye Series For Light Scattering By A Spheroid, Feng Xu, James A. Lock, Cameron Tropea

Physics Faculty Publications

The Debye series is developed for electromagnetic scattering by a spheroid in order to decompose the far-zone fields into various physical processes. The geometrical rainbow angle and supernumerary spacing parameter are determined from the Debye intensity by fitting the results to an Airy function and comparing them to their assumed values in ray optics and Airy theory, respectively. Eccentricity-related scattering phenomena including the rainbow's angular shift, the disappearance of the rainbow, and the rainbow-enhanced glory are quantitatively demonstrated and analyzed. (c) 2010 Optical Society of America

Go to article

Debye Series For Light Scattering By A Nonspherical Particle, Feng Xu, James A. Lock, Gérard Gouesbet Apr 2010

Debye Series For Light Scattering By A Nonspherical Particle, Feng Xu, James A. Lock, Gérard Gouesbet

Physics Faculty Publications

The Debye series is developed for scattering of light by a homogeneous nonspherical particle to interpret the angular dependence of the scattered intensity in terms of various physical processes. In contrast to the previously developed Debye series for several regularly shaped particles that mirror the orthogonal curvilinear coordinate system where the variable-separation method can be applied, we develop and verify the Debye series in a coordinate-independent way using the extended boundary condition method. Verification computations are made for an oblate spheroidal water droplet of equivalent-volume sphere radius 10 mu m.

Go to article

Optical Caustics Observed In Light Scattered By An Oblate Spheroid, James A. Lock, Feng Xu Mar 2010

Optical Caustics Observed In Light Scattered By An Oblate Spheroid, James A. Lock, Feng Xu

Physics Faculty Publications

The electromagnetic fields scattered when a plane wave is incident on an oblate spheroid in the side-on orientation may be calculated using a generalization of Mie theory, and the results may be decomposed in a Debye series expansion. A number of optical caustics are observed in the computed scattered intensity for the one internal reflection portion of the Debye series for scattering angles in the vicinity of the first-order rainbow, and are analyzed in terms of the rainbow, transverse cusp, and hyperbolic umbilic caustics of catastrophe optics. The specific features of these three caustics are described, as is their assembly …

Go to article

Stability Of Choice In The Honey Bee Nest-Site Selection Process, Andrew L. Nevai, Kevin M. Passino, Parthasarathy Srinivasan Mar 2010

Stability Of Choice In The Honey Bee Nest-Site Selection Process, Andrew L. Nevai, Kevin M. Passino, Parthasarathy Srinivasan

Mathematics and Statistics Faculty Publications

We introduce a pair of compartment models for the honey bee nest-site selection process that lend themselves to analytic methods. The first model represents a swarm of bees deciding whether a site is viable, and the second characterizes its ability to select between two viable sites. We find that the one-site assessment process has two equilibrium states: a disinterested equilibrium (DE) in which the bees show no interest in the site and an interested equilibrium (IE) in which bees show interest. In analogy with epidemic models, we define basic and absolute recruitment numbers (R0R0 and B0B0) as measures of the …

Go to article

Subclinical Myocardial Necrosis And Cardiovascular Risk In Stable Patients Undergoing Elective Cardiac Evaluation, W.H. Wilson Tang, Yuping Wu, Stephen J. Nicholls, Danielle M. Brennan, Michael Pepoy, Shirley Mann, Alan Pratt, Frederick Van Lente, Stanley L. Hazen Mar 2010

Subclinical Myocardial Necrosis And Cardiovascular Risk In Stable Patients Undergoing Elective Cardiac Evaluation, W.H. Wilson Tang, Yuping Wu, Stephen J. Nicholls, Danielle M. Brennan, Michael Pepoy, Shirley Mann, Alan Pratt, Frederick Van Lente, Stanley L. Hazen

Mathematics and Statistics Faculty Publications

Objective— The presence of subclinical myocardial necrosis as a prodrome to longer-term adverse cardiac event risk has been debated. The debate has focused predominantly within patients with acute coronary syndrome, and on issues of troponin assay variability and accuracy of detection, rather than on the clinical significance of the presence of subclinical myocardial necrosis (ie, “troponin leak”) within stable cardiac patients. Herein, we examine the relationship between different degrees of subclinical myocardial necrosis and long-term adverse clinical outcomes within a stable cardiac patient population with essentially normal renal function. Methods and Results— Sequential consenting patients (N=3828; median creatinine clearance, 100 …

Go to article

Selective Regulation Of Aromatase Expression For Drug Discovery, Robert W. Brueggemeier, Bin Su, Michael V. Darby, Yasuro Sugimoto Feb 2010

Selective Regulation Of Aromatase Expression For Drug Discovery, Robert W. Brueggemeier, Bin Su, Michael V. Darby, Yasuro Sugimoto

Chemistry Faculty Publications

Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast cancer, and aromatase activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Complex regulation of aromatase expression in human tissues involves alternative promoter sites that provide tissue-specific control. Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes. Additionally, COX selective inhibitors can suppress CYP19 gene expression and decrease aromatase activity. Our current hypothesis is that pharmacological regulation of aromatase can act locally to decrease the …

Go to article

Oxygen Regulates The Effective Diffusion Distance Of Nitric Oxide In The Aortic Wall, Xiaoping Liu, Parthasarathy Srinivasan, Eric Collard, Paula Grajdeanu, Kevin Lok, Sarah E. Boyle, Avner Friedman, Jay L. Zweier Feb 2010

Oxygen Regulates The Effective Diffusion Distance Of Nitric Oxide In The Aortic Wall, Xiaoping Liu, Parthasarathy Srinivasan, Eric Collard, Paula Grajdeanu, Kevin Lok, Sarah E. Boyle, Avner Friedman, Jay L. Zweier

Mathematics and Statistics Faculty Publications

Endothelium-derived nitric oxide (NO) is critical in maintaining vascular tone. Accumulating evidence shows that NO bioavailability is regulated by oxygen concentration. However, it is unclear to what extent the oxygen concentration regulates NO bioavailability in the vascular wall. In this study, a recently developed experimental setup was used to measure the NO diffusion flux across the aortic wall at various oxygen concentrations. It was observed that for a constant NO concentration at the endothelial surface, the measured NO diffusion flux out of the adventitial surface at [O2] = 0 μM is around fivefold greater than at [O2] = 150 μM, …

Go to article

A Majorization Algorithm For Constrained Correlation Matrix Approximation, Daniel J. Simon, Jeff Abell Feb 2010

A Majorization Algorithm For Constrained Correlation Matrix Approximation, Daniel J. Simon, Jeff Abell

Electrical and Computer Engineering Faculty Publications

We desire to find a correlation matrix of a given rank that is as close as possible to an input matrix R, subject to the constraint that specified elements in must be zero. Our optimality criterion is the weighted Frobenius norm of the approximation error, and we use a constrained majorization algorithm to solve the problem. Although many correlation matrix approximation approaches have been proposed, this specific problem, with the rank specification and the constraints, has not been studied until now. We discuss solution feasibility, convergence, and computational effort. We also present several examples.

Go to article

Homozygous Frameshift Mutation In Tmco1 Causes A Syndrome With Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation, Baozhong Xin, Erik G. Puffenberger, Susan Turben, Haiyan Tan, Aimin Zhou, Heng Wang Jan 2010

Homozygous Frameshift Mutation In Tmco1 Causes A Syndrome With Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation, Baozhong Xin, Erik G. Puffenberger, Susan Turben, Haiyan Tan, Aimin Zhou, Heng Wang

Chemistry Faculty Publications

We identified an autosomal recessive condition in 11 individuals in the Old Order Amish of northeastern Ohio. The syndrome was characterized by distinctive craniofacial dysmorphism, skeletal anomalies, and mental retardation. The typical craniofacial dysmorphism included brachycephaly, highly arched bushy eyebrows, synophrys, long eyelashes, low-set ears, microdontism of primary teeth, and generalized gingival hyperplasia, whereas Sprengel deformity of scapula, fusion of spine, rib abnormities, pectus excavatum, and pes planus represented skeletal anomalies. The genome-wide homozygosity mapping using six affected individuals localized the disease gene to a 3.3-Mb region on chromosome 1q23.3-q24.1. Candidate gene sequencing identified a homozygous frameshift mutation, c.139_140delAG, in …

Go to article

Targeting Base Excision Repair Suggests A New Therapeutic Strategy Of Fludarabine For The Treatment Of Chronic Lymphocytic Leukemia, A. D. Bulgar, M. Snell, J. R. Donze, E. B. Kirkland, Lan Li, Shuming Yang, Yan Xu, S. L. Gerson, Lili Liu Jan 2010

Targeting Base Excision Repair Suggests A New Therapeutic Strategy Of Fludarabine For The Treatment Of Chronic Lymphocytic Leukemia, A. D. Bulgar, M. Snell, J. R. Donze, E. B. Kirkland, Lan Li, Shuming Yang, Yan Xu, S. L. Gerson, Lili Liu

Chemistry Faculty Publications

No abstract provided.

Go to article

Racial/Ethnic Health Disparities In Northeast Ohio, Mark Salling, Joseph Ahern Jan 2010

Racial/Ethnic Health Disparities In Northeast Ohio, Mark Salling, Joseph Ahern

All Maxine Goodman Levin School of Urban Affairs Publications

Racial/Ethnic Health Disparities in Northeast Ohio, Planning & Action, The Center for Community Solutions, Vol. 63, No. 4 (July), 2010, pp. 12-15.

Go to article

Putting Artists On The Map: A Five Part Study Of Greater Cleveland Artists' Location Decisions - Part 1: Summary Report, Mark Salling, Gregory Soltis, Charles Post, Sharon Bliss, Ellen Cyran Jan 2010

Putting Artists On The Map: A Five Part Study Of Greater Cleveland Artists' Location Decisions - Part 1: Summary Report, Mark Salling, Gregory Soltis, Charles Post, Sharon Bliss, Ellen Cyran

All Maxine Goodman Levin School of Urban Affairs Publications

A series of reports detailing the residential and work space location preferences of Cuyahoga county's artists.

Go to article

Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla Jan 2010

Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla

ETD Archive

Cell surface carbohydrates existing as parts of glycoproteins, glycolipids, and other conjugates present the first information about cell to the outside world and are intimately involved in various biological events such as intercellular communication, and molecular and cellular targeting. However, mechanisms of most processes at the molecular level are still unclear. Therefore, it is very important to develop carbohydrate-specific binding molecules for rapid, efficient, sensitive purification and accurate analysis of complex carbohydrate structures as well as their functions. Furthermore, carbohydrate-specific binding molecules can be expected to be used in medical diagnostic applications for carbohydrate biomarkers. In this thesis study, oriented …

Go to article

Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson Jan 2010

Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson

ETD Archive

High species diversity and complexity of forest-floor food webs present a challenge for understanding the role of species interactions (e.g. competition and predation) as regulatory mechanisms for ecosystem processes such as decomposition and nutrient cycling. In particular, we understand very little about the roles of forest-floor predators in regulating diversity and abundance of lower trophic levels and ecosystem processes. However, ecological theory and several studies suggest that interactions among intraguild predators (IGP) may be important controls of diversity and abundance of organisms and detritus in lower trophic levels within food webs. A key prediction is that interactions among predators weaken …

Go to article

Next Last