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Articles 1 - 29 of 29
Full-Text Articles in Physical Sciences and Mathematics
A Control Switch For Prothrombinase: Characterization Of A Hirudin-Like Pentapeptide From The Cooh Terminus Of Factor Va Heavy Chain That Regulates The Rate And Pathway For Prothrombin Activation, Michael A. Bukys, Paul Y. Kim, Michael E. Nesheim, Michael Kalafatis
A Control Switch For Prothrombinase: Characterization Of A Hirudin-Like Pentapeptide From The Cooh Terminus Of Factor Va Heavy Chain That Regulates The Rate And Pathway For Prothrombin Activation, Michael A. Bukys, Paul Y. Kim, Michael E. Nesheim, Michael Kalafatis
Chemistry Faculty Publications
Membrane-bound factor Xa alone catalyzes prothrombin activation following initial cleavage at Arg(271) and prethrombin 2 formation (pre2 pathway). Factor Va directs prothrombin activation by factor Xa through the meizothrombin pathway, characterized by initial cleavage at Arg(320) (meizo pathway). We have shown previously that a pentapeptide encompassing amino acid sequence 695-699 from the COOH terminus of the heavy chain of factor Va (Asp-Tyr-Asp-Tyr-Gln, DYDYQ) inhibits prothrombin activation by prothrombinase in a competitive manner with respect to substrate. To understand the mechanism of inhibition of thrombin formation by DYDYQ, we have studied prothrombin activation by gel electrophoresis. Titration of plasma-derived prothrombin activation …
Why Do Descending Shells Around Cumulus Clouds Exist?, Thijs Heus, Harm J.J. Jonker
Why Do Descending Shells Around Cumulus Clouds Exist?, Thijs Heus, Harm J.J. Jonker
Physics Faculty Publications
No abstract provided.
The Influence Of The Sub-Cloud Moisture Field On Cloud Size Distributions And The Consequences For Entrainment, Harm J.J. Jonker, Remco A. Verzijlbergh, Thijs Heus, A. Pier Siebesma
The Influence Of The Sub-Cloud Moisture Field On Cloud Size Distributions And The Consequences For Entrainment, Harm J.J. Jonker, Remco A. Verzijlbergh, Thijs Heus, A. Pier Siebesma
Physics Faculty Publications
No abstract provided.
Lifecycle Analysis Of Cumulus Clouds Using A 3d Virtual Reality Environment, Thijs Heus, Harm J.J. Jonker, Eric J. Griffith, Frits H. Post
Lifecycle Analysis Of Cumulus Clouds Using A 3d Virtual Reality Environment, Thijs Heus, Harm J.J. Jonker, Eric J. Griffith, Frits H. Post
Physics Faculty Publications
No abstract provided.
Partial-Wave Expansions Of Angular Spectra Of Plane Waves, James A. Lock
Partial-Wave Expansions Of Angular Spectra Of Plane Waves, James A. Lock
Physics Faculty Publications
Focused electromagnetic beams are frequently modeled by either an angular spectrum of plane waves or a partial-wave sum of spherical multipole waves. The connection between these two beam models is explored here. The partial-wave expansion of an angular spectrum containing evanescent components is found to possess only odd partial waves. On the other hand, the partial-wave expansion of an alternate angular spectrum constructed so as to be free of evanescent components contains all partial waves but describes a propagating beam with a small amount of standing-wave component mixed in. A procedure is described for minimizing the standing-wave component so as …
2006 Scholars And Artists Bibliography, Daniel J. Simon, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library
2006 Scholars And Artists Bibliography, Daniel J. Simon, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library
Scholars and Artists Bibliographies
This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti. Dr. Dan Simon was the guest speaker.
Quantifying Fluid Mixing With The Shannon Entropy, Marco Camesasca, Miron Kaufman, Ica Manas Zloczower
Quantifying Fluid Mixing With The Shannon Entropy, Marco Camesasca, Miron Kaufman, Ica Manas Zloczower
Physics Faculty Publications
We introduce a methodology to quantify the quality of mixing in various systems, including polymeric ones, by adapting the Shannon information entropy. For illustrative purposes we use particle advection of two species in a two-dimensional cavity flow. We compute the entropy by using the probability of finding a suitable chosen group/complex of particles of a given species, at a given location. By choosing the size of the group to be in direct proportion to the overall concentration of the components in the mixture we ensure that the entropic measure is maximized for the case of perfect mixing, that is, when …
A 2:1 Complex Of 1,3-Bis(9h-Carbazol-9-Yl)Propane And TetraChloro-P-Benzoquinone (P-Chloranil), Mustafa Arslan, Randolph B. Krafcik, John Masnovi, Ronald J. Baker
A 2:1 Complex Of 1,3-Bis(9h-Carbazol-9-Yl)Propane And TetraChloro-P-Benzoquinone (P-Chloranil), Mustafa Arslan, Randolph B. Krafcik, John Masnovi, Ronald J. Baker
Chemistry Faculty Publications
In the title electron donor–acceptor complex, C27H22N2·0.5C6Cl4O2, the p-chloranil molecule lies on a crystallographic inversion center, which is located at the center of the benzene ring. In the crystal structure, one p-chloranil molecule lies above and below the central rings of each donor group of two neighboring 1,3-bis(9H-carbazol-9-yl)propane molecules, with a ring-centroid separation of 3.444 (1) Å. The angle between the planes of the stacking rings of the carbazole and p-chloranil molecules is 3.4 (2)°.
(E,E)-1,3-Bis[9,10-Dihydro-9-Nitro-10-(TrinitroMethYl)-9-AnthrYl]Propane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
(E,E)-1,3-Bis[9,10-Dihydro-9-Nitro-10-(TrinitroMethYl)-9-AnthrYl]Propane, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
Chemistry Faculty Publications
The title compound, C33H24N8O16, was obtained as a product of the photoreaction between 1,3-di-9-anthrylpropane and tetranitromethane. The molecule occupies a special position on a twofold axis. The trinitromethyl and nitro substituents on the 9,10-dihydroacridine system are E oriented.
Rnase L: Its Biological Roles And Regulation, Shu Ling Liang, David Quirk, Aimin Zhou
Rnase L: Its Biological Roles And Regulation, Shu Ling Liang, David Quirk, Aimin Zhou
Chemistry Faculty Publications
2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.
10,10′-Dinitro-10,10′-(Butane-1,4-DiYl)Dianthracen-9(10h)-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
10,10′-Dinitro-10,10′-(Butane-1,4-DiYl)Dianthracen-9(10h)-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
Chemistry Faculty Publications
The title compound, C32H24N2O6, was obtained as the decomposition product of (E,E)-1,4-bis[9,10-dihydro-9-nitro-10-(trinitromethyl)-9-anthryl]butane, which was synthesized via a photochemical reaction of 1,4-bis(9-anthryl)butane with tetranitromethane. The asymmetric unit contains one half-molecule; the complete molecule is generated by a center of inversion. The crystal packing is determined mainly by intermolecular C—H⋯O interactions.
The Structural Integrity Of Anion Binding Exosite I Of Thrombin Is Required And Sufficient For Timely Cleavage And Activation Of Factor V And Factor Viii, Michael A. Bukys, Tivadar Orban, Paul Y. Kim, Daniel O. Beck, Michael E. Nesheim, Michael Kalafatis
The Structural Integrity Of Anion Binding Exosite I Of Thrombin Is Required And Sufficient For Timely Cleavage And Activation Of Factor V And Factor Viii, Michael A. Bukys, Tivadar Orban, Paul Y. Kim, Daniel O. Beck, Michael E. Nesheim, Michael Kalafatis
Chemistry Faculty Publications
Alpha-thrombin has two separate electropositive binding exosites (anion binding exosite I, ABE-I and anion binding exosite II, ABE-II) that are involved in substrate tethering necessary for efficient catalysis. Alpha-thrombin catalyzes the activation of factor V and factor VIII following discrete proteolytic cleavages. Requirement for both anion binding exosites of the enzyme has been suggested for the activation of both procofactors by alpha-thrombin. We have used plasma-derived alpha-thrombin, beta-thrombin (a thrombin molecule that has only ABE-II available), and a recombinant prothrombin molecule rMZ-II (R155A/R284A/R271A) that can only be cleaved at Arg(320) (resulting in an enzymatically active molecule that has only ABE-I …
Numerical Simulation And Graphical Analysis Of In Vitro Benign Tumor Growth: Application Of Single-Particle State Bosonic Matter Equation With Length Scaling, Pradip K. Biswas, Jiansen Niu, Tobias Frederico, Valentin Gogonea
Numerical Simulation And Graphical Analysis Of In Vitro Benign Tumor Growth: Application Of Single-Particle State Bosonic Matter Equation With Length Scaling, Pradip K. Biswas, Jiansen Niu, Tobias Frederico, Valentin Gogonea
Chemistry Faculty Publications
We describe the application of a non-linear single-particle state bosonic condensate equation to simulate multicellular tumor growth by treating it as a coupling of two classical wave equations with real components. With one component representing the amplitude of the cells in their volume growth phase and the other representing the amplitude of the cells in their proliferation or mitosis phase, the two components of the coupled equation feed each other during the time evolution and are coupled together through diffusion and other linear and non-linear terms. The features of quiescent and necrotic cells, which result from poor nutrient diffusion into …
Scattering Of A Tightly Focused Beam By An Optically Trapped Particle, James A. Lock, Susan Y. Wrbanek, Kenneth E. Weiland
Scattering Of A Tightly Focused Beam By An Optically Trapped Particle, James A. Lock, Susan Y. Wrbanek, Kenneth E. Weiland
Physics Faculty Publications
Near-forward scattering of an optically trapped 5-mu m-radius polystyrene latex sphere by the trapping beam was examined both theoretically and experimentally. Since the trapping beam is tightly focused, the beam fields superpose and interfere with the scattered fields in the forward hemisphere. The observed light intensity consists of a series of concentric bright and dark fringes centered about the forward-scattering direction. Both the number of fringes and their contrast depend on the position of the trapping beam focal waist with respect to the sphere. The fringes are caused by diffraction that is due to the truncation of the tail of …
10,10′-Dinitro-10,10′-(Propane-1,3-DiYl)Di-10h-Anthracen-9-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
10,10′-Dinitro-10,10′-(Propane-1,3-DiYl)Di-10h-Anthracen-9-One, Mustafa Arslan, Erol Asker, John Masnovi, Ronald J. Baker
Chemistry Faculty Publications
The title compound, C31H22N2O6, was obtained as the decomposition product of (E,E)-1,3-bis[9,10-dihydro-9-nitro-10-(trinitromethyl)-9-anthryl]propane, which was synthesized via a photochemical reaction of 1,3-di-9-anthrylpropane with tetranitromethane. Intermolecular C—H⋯O interactions are the most prominent features of the crystal packing; no indications of any intermolecular π–π stacking were found.
Group Iv Solid State Proposals For Quantum Computation, Petru S. Fodor, J. Levy
Group Iv Solid State Proposals For Quantum Computation, Petru S. Fodor, J. Levy
Physics Faculty Publications
The discovery of the quantum factorization algorithm more than a decade ago triggered intense interest in exploring possible physical realizations of quantum computers. Among the many solid state proposals, electron and nuclear spins in Si and group IV related materials have long coherence times and the capability of state preparation, gating and read-out using electric, magnetic and optical fields. Proposals involving silicon seek to take advantage of an existing mature technology and the implicit promise of scalability from solid state materials. Nevertheless, building such quantum systems depends in many cases on the development of fabrication techniques with nearly atomic precision. …
9-Ethyl-3-(9h-9-EthylCarbazol-3-Yl)-4-Nitro-9h-Carbazole, Erol Asker, John Masnovi
9-Ethyl-3-(9h-9-EthylCarbazol-3-Yl)-4-Nitro-9h-Carbazole, Erol Asker, John Masnovi
Chemistry Faculty Publications
In the molecule of the title compound, C28H23N3O2, the nitro group is almost perpendicular to the carbazole ring to which it is attached. The crystal packing is determined by C—H⋯O and π–π interactions, where the nitrated carbazole ring of one molecule associates in a shifted parallel planar orientation with the centrosymmetrically related non-nitrated carbazole ring of a neighbouring molecule.
Bis(9-EthylCarbazol-3-Yl)Ethane, Erol Asker, John Masnovi
Bis(9-EthylCarbazol-3-Yl)Ethane, Erol Asker, John Masnovi
Chemistry Faculty Publications
In the title compound, C30H28N2, each carbazole skeleton is essentially planar. The planes of the two carbazole ring systems are nearly parallel, with a dihedral angle of 2.33 (19)°. The crystal packing is stabilized only by van der Waals forces and weak C—H⋯π interactions.
Global Residues For Sparse Polynomial Systems, Ivan Soprunov
Global Residues For Sparse Polynomial Systems, Ivan Soprunov
Mathematics and Statistics Faculty Publications
We consider families of sparse Laurent polynomials f1, . . . , fn with a finite set of common zeros Z f in the torus Tn = (C − {0})n. The global residue assigns to every Laurent polynomial g the sum of its Grothendieck residues over Z f . We present a new symbolic algorithm for computing the global residue as a rational function of the coefficients of the fi when the Newton polytopes of the fi are full-dimensional. Our results have consequences in sparse polynomial interpolation and lattice point enumeration in Minkowski sums of polytopes.
Forecasting Police Calls During Peak Times For The City Of Cleveland, John P. Holcomb, Norean Radke Sharpe
Forecasting Police Calls During Peak Times For The City Of Cleveland, John P. Holcomb, Norean Radke Sharpe
Mathematics and Statistics Faculty Publications
For a period of time, professors from the Cleveland State University worked closely with the City of Cleveland Police Department. This partnership resulted in access to police records cataloging all emergency 911 calls for the city since 1995. Here, we describe forecasting approaches that can be used by the Police Department based on hourly 911 calls in the years 2001 to 2003 throughout the city during peak call time: the third shift during summer months. This case study is appropriate for class discussions in advanced courses in statistics to explore the application of time series analysis techniques.
9,9′-Diethyl-3,3′-Di-9h-CarbazolYl, Erol Asker, John Masnovi
9,9′-Diethyl-3,3′-Di-9h-CarbazolYl, Erol Asker, John Masnovi
Chemistry Faculty Publications
In the title compound, C28H24N2, the carbazole ring systems are essentially planar to within 0.076 (3) Å. The dihedral angle between the planes of the ring systems is 40.38 (4)°. The contribution of intermolecular π–π interactions to the molecular stacking is observed.
Bis(9-EthylCarbazol-3-Yl)Methane, Erol Asker, John Masnovi
Bis(9-EthylCarbazol-3-Yl)Methane, Erol Asker, John Masnovi
Chemistry Faculty Publications
In the title compound, C29H26N2, the carbazole ring systems are essentially planar. There is no indication of π–π interactions in the crystal structure, adjacent carbazole groups being non-parallel.
Training Opportunities Available To Ohio Lake Erie Basin Local Decision-Makers Regarding The Economic And Fiscal Benefits Of Coastal And Watershed Stewardship, Wendy A. Kellogg, Erica Matheny
Training Opportunities Available To Ohio Lake Erie Basin Local Decision-Makers Regarding The Economic And Fiscal Benefits Of Coastal And Watershed Stewardship, Wendy A. Kellogg, Erica Matheny
All Maxine Goodman Levin School of Urban Affairs Publications
This paper presents new knowledge about the current status of training on the economic value of stewardship practices in the Ohio Lake Erie basin. Local decision-makers shape coastal and watershed conditions but often do not appreciate the economic, fiscal, and ecological benefits that could be gained from sound stewardship practices. This study investigated the information and training about economic benefits available in the Ohio Lake Erie basin. Training providers and technical assistance professionals helped identify key training needs and challenges to decision-maker awareness of benefits. We found relatively few organizations offering training that incorporate economic or fiscal benefits into their …
A C-Symplectic Free S1-Manifold With Contractible Orbits And Cat = 1/2 Dim, Christopher Allday, John Oprea
A C-Symplectic Free S1-Manifold With Contractible Orbits And Cat = 1/2 Dim, Christopher Allday, John Oprea
Mathematics and Statistics Faculty Publications
An interesting question in symplectic geometry concerns whether or not a closed symplectic manifold can have a free symplectic circle action with orbits contractible in the manifold. Here we present a c-symplectic example, thus showing that the problem is truly geometric as opposed to topological. Furthermore, we see that our example is the only known example of a c-symplectic manifold having non-trivial fundamental group and Lusternik-Schnirelmann category precisely half its dimension.
Foreign-Born Population In Selected Ohio Cities, 1870 To 2000 A Brief Descriptive Report, Mark Salling, Ellen Cyran
Foreign-Born Population In Selected Ohio Cities, 1870 To 2000 A Brief Descriptive Report, Mark Salling, Ellen Cyran
All Maxine Goodman Levin School of Urban Affairs Publications
No abstract provided.
Using The Census Bureau's Public Use Microdata For Migration Analysis, Mark Salling, Ellen Cyran
Using The Census Bureau's Public Use Microdata For Migration Analysis, Mark Salling, Ellen Cyran
All Maxine Goodman Levin School of Urban Affairs Publications
Using the Census Bureau's Public Use Microdata for Migration Analysis, Proceedings of the annual conference of the Urban and Regional Information Systems Association, Vancouver, BC, Canada, September 2006, pp.336-348.
You Should Run For Office (Video), Kevin O'Brien, Grace Drake
You Should Run For Office (Video), Kevin O'Brien, Grace Drake
All Maxine Goodman Levin School of Urban Affairs Publications
No abstract provided.
Fluorescent Analysis Of Translesion Dna Synthesis By Using A Novel, Non-Natural Nucleotide Analogue, Irene Lee, Anthony J. Berdis
Fluorescent Analysis Of Translesion Dna Synthesis By Using A Novel, Non-Natural Nucleotide Analogue, Irene Lee, Anthony J. Berdis
Chemistry Faculty Publications
The replication of damaged DNA is a promutagenic process that can lead to disease development. This report evaluates the dynamics of nucleotide incorporation opposite an abasic site, a commonly formed DNA lesion, by using two fluorescent nucleotide analogues, 2-aminopurine deoxyribose triphosphate (2-APTP) and 5-phenylindole deoxyribose triphosphate (5-PhITP). In both cases, the kinetics of incorporation were compared by using a 32 P-radiolabel extension assay versus a fluorescence-quenching assay. Although 2-APTP is efficiently incorporated opposite a templating nucleobase (thymine), the kinetics for incorporation opposite an abasic site are significantly slower. The lower catalytic efficiency hinders its use as a probe to study …
Recent Developments Inthe Mechanistic Enzymology Of The Atp-Dependent Lon Protease From Escherichia Coli: Highlights From Kinetic Studies, Irene Lee, Anthony J. Berdis, Carolyn K. Suzuki
Recent Developments Inthe Mechanistic Enzymology Of The Atp-Dependent Lon Protease From Escherichia Coli: Highlights From Kinetic Studies, Irene Lee, Anthony J. Berdis, Carolyn K. Suzuki
Chemistry Faculty Publications
Lon protease, also known as protease La, is one of the simplest ATP-dependent proteases that plays vital roles in maintaining cellular functions by selectively eliminating misfolded, damaged and certain short-lived regulatory proteins. Although Lon is a homo-oligomer, each subunit of Lon contains both an ATPase and a protease active site. This relatively simple architecture compared to other hetero-oligomeric ATP-dependent proteases such as the proteasome makes Lon a useful paradigm for studying the mechanism of ATP-dependent proteolysis. In this article, we survey some recent developments in the mechanistic characterization of Lon with an emphasis on the utilization of pre-steady-state enzyme kinetic …