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Full-Text Articles in Physical Sciences and Mathematics
Strings, Chains, And Ropes, Darryl H. Yong
Strings, Chains, And Ropes, Darryl H. Yong
All HMC Faculty Publications and Research
Following Antman [Amer. Math. Mon., 87 (1980), pp. 359–370], we advocate a more physically realistic and systematic derivation of the wave equation suitable for a typical undergraduate course in partial differential equations. To demonstrate the utility of this derivation, three applications that follow naturally are described: strings, hanging chains, and jump ropes.
Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore
Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore
All HMC Faculty Publications and Research
In this paper, we use control theory to determine optimal treatment regimens for HIV patients, taking into account treatment-resistant mutations of the virus. We perform optimal control analysis on a model developed previously for the dynamics of HIV with strains of various resistance to treatment (Moore and Gu, 2005). This model incorporates three types of resistance to treatments: strains that are not responsive to protease inhibitors, strains not responsive to reverse transcriptase inhibitors, and strains not responsive to either of these treatments. We solve for the optimal treatment regimens analytically and numerically. We find parameter regimes for which optimal dosing …